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Betamethasone acetate

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Identification
Molecular formula
C24H31FO6
CAS number
987-24-6
IUPAC name
[2-(12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl)-2-oxo-ethyl] acetate
State
State

At room temperature, betamethasone acetate is in a solid state. It is a crystalline powder and is not commonly found in a pure liquid or gaseous state under standard conditions.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.20
Boiling point (Celsius)
284.60
Boiling point (Kelvin)
557.80
General information
Molecular weight
476.52g/mol
Molar mass
476.5160g/mol
Density
1.1870g/cm3
Appearence

Betamethasone acetate typically appears as a white to creamy white crystalline powder. It is often used in various pharmaceutical forms, and while it may be found in liquid suspensions, tablets, or creams, the pure compound itself is solid.

Comment on solubility

Solubility of [2-(12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl)-2-oxo-ethyl] acetate (C24H31FO6)

The solubility of [2-(12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl)-2-oxo-ethyl] acetate is influenced by several factors due to its complex structure. Here are some important considerations:

  • Polarity: The presence of multiple functional groups can create varying levels of polarity within the compound, affecting its interactions with solvents.
  • Hydrogen Bonding: The hydroxy (-OH) groups may enable hydrogen bonding with polar solvents (like water), potentially enhancing solubility.
  • Size and Structure: The larger, multi-cyclic structure might hinder solubility in certain solvents, particularly non-polar ones.
  • Fluorine Atoms: The inclusion of fluorine atoms can influence the overall solubility characteristics, potentially decreasing solubility in water due to increased hydrophobicity.

In summary, this compound's solubility is likely to be moderate in polar solvents due to the balance of hydrophilic groups and hydrophobic regions. As with many complex organic compounds, experimental solubility testing is essential to accurately determine its solubility profile in various solvents.

Interesting facts

Interesting Facts about 2-(12,19-Difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl)-2-oxo-ethyl Acetate

2-(12,19-Difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl)-2-oxo-ethyl acetate is a fascinating compound, notable for its complex structure and potential applications in various fields of chemistry and biology. Below are some engaging insights into this diverse compound:

  • Complexity in Structure: The structure features multiple fused rings, making it a part of the class of polycyclic compounds. This configuration not only influences the compound’s stability but is also significant in the study of various organic reactions.
  • Fluorine Substituents: The presence of difluoro groups is particularly interesting because fluorine can modify the chemical properties dramatically. This might enhance lipophilicity, and chemical reactivity, and affect biological activities.
  • Applications in Medicine: Compounds of this type, especially those modified with fluorine and hydroxyl groups, are often studied for their potential pharmaceutical properties, possibly serving as precursors to drug candidates.
  • Synthetic Challenges: The synthesis of such intricate structures may involve multi-step reactions, demanding advanced techniques and skilled chemists to navigate the synthetic pathways effectively.
  • Environmental Impact: As with many synthetic compounds, understanding the environmental fate and toxicity is crucial. Researchers often examine how similar compounds break down in nature and their potential ecological footprints.

In summary, 2-(12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl)-2-oxo-ethyl acetate is not just another chemical; it encapsulates numerous scientific principles and applications, seducing chemists with its richness and potential.

Synonyms
Topsyn
Metosyn
Bestasone
Biscosal
Cortalar
Straderm
Topsymin
Lidex
Synalar acetate
Fluocinolone acetonide 21-acetate
Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6a,11b,16a)-
Dermaplus
Synalate
Topsyne
NSC101791
SCHEMBL13026147
DTXSID90859342
WJOHZNCJWYWUJD-UHFFFAOYSA-N
Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6.alpha.,11.beta.,16.alpha.)-
AKOS025149900
(6.alpha.,11.beta.,16.alpha.)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidine)bis(oxy)]pregna-1,4-diene-3,20-dione
[2-(12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl)-2-oxoethyl] acetate
[2-[(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.0^{2,9.0^{4,8.0^{13,18]icosa-14,17-dien-8-yl]-2-oxoethyl] acetate
2-(4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate
2-(4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bh-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate #
6.alpha.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone, 21-acetate
6.alpha.,9-Difluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone, 21-acetate
Pregna-1,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6.alpha.,11.beta.,16.alpha.)-
Pregna-1,20-dione, 6.alpha.,9-difluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate
Pregna-1,4-diene-3,20-dione, 6-.alpha., 9-difluoro-11-.beta.,16-.alpha.,17,21-tetrahydroxy-, cyclic17-acetal with acetone, 21-acetate
Pregna-1,4-diene-3,20-dione, 6.alpha.,9-difluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate