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Fluticasone propionate

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Identification
Molecular formula
C25H31F3O5S
CAS number
80474-14-2
IUPAC name
[2-[(12R)-12-fluoro-11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,14,17-trien-8-yl]-2-oxo-ethyl] acetate
State
State
Fluticasone propionate is a solid at room temperature. It is processed into various forms for inhalation or topical application.
Melting point (Celsius)
273.00
Melting point (Kelvin)
546.20
Boiling point (Celsius)
364.85
Boiling point (Kelvin)
638.00
General information
Molecular weight
500.57g/mol
Molar mass
500.5690g/mol
Density
1.4900g/cm3
Appearence

Fluticasone propionate is a white to off-white powder. It is often provided in a micronized form for improved solubility and absorption.

Comment on solubility

Solubility Overview

The compound [2-[(12R)-12-fluoro-11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,14,17-trien-8-yl]-2-oxo-ethyl] acetate presents intriguing characteristics regarding its solubility. Understanding the solubility of complex organic compounds like this one can often be a multifaceted challenge, influenced by both structural and environmental factors.

Factors Affecting Solubility

Several key factors contribute to the solubility of such a compound:

  • Polarity: The presence of polar functional groups (such as acetates and hydroxyls) typically enhances solubility in polar solvents like water.
  • Hydrophobic Interactions: The large hydrophobic regions in the compound may limit solubility in aqueous environments but increase solubility in non-polar solvents.
  • Temperature: Solubility is often temperature-dependent; increasing temperature usually increases solubility for solid compounds.

General Solubility Behavior

For compounds similar to this one, it may be observed that:

  • Better solubility in organic solvents, such as ethanol or dimethyl sulfoxide (DMSO), due to compatibility with non-polar regions.
  • Limited wine solubility increases owing to the amphiphilic nature that may interact positively with polar media.
  • Factors such as pH of the solution can also play a significant role, particularly if ionization occurs.

In conclusion, the solubility of this complex organic compound is determined by a dynamic interplay of its structure and the solvent environment. A detailed experimental approach is often essential to pinpoint its solubility characteristics in various conditions.

Interesting facts

Interesting Facts About 2-[(12R)-12-fluoro-11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,14,17-trien-8-yl]-2-oxo-ethyl acetate

This compound is a fascinating member of the large class of organic compounds known as acetates. Acetates are commonly derived from acetic acid and often have various applications in biological systems and synthetic pathways. Here are some intriguing aspects of this particular compound:

  • Stereochemistry: The structure includes a chiral center at the 12R position, which may contribute to specific biological activities and interactions that are contingent on its three-dimensional orientation.
  • Functional Groups: The compound features multiple functional groups, including a fluoro group, a hydroxy group, and an oxo (ketone) group. These play crucial roles in determining the reactivity and solubility of the molecule.
  • Complexity: With its intricate pentacyclic structure, this compound's synthesis and characterization present significant challenges. Understanding such complex molecules can lead to breakthroughs in designing new drugs or materials.
  • Biological Relevance: Compounds of similar architecture often exhibit interesting pharmacological properties. This raises questions about its potential, especially in medicinal chemistry and drug discovery.
  • Research Potential: Given its complexity, there’s an immense scope for research into its synthetic pathways, mechanisms of action, and applications in various fields, including medicinal and agricultural chemistry.

Overall, 2-[(12R)-12-fluoro-11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,14,17-trien-8-yl]-2-oxo-ethyl acetate serves as a compelling example of how the intricacies of chemical structures can correlate with their potential uses in science, particularly in the challenging yet rewarding arena of drug development and chemical research.

Synonyms
SCHEMBL1651378