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Ninhydrin

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Identification
Molecular formula
C9H6O4
CAS number
485-47-2
IUPAC name
2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid
State
State

At room temperature, Ninhydrin is in a solid state, appearing as a powder which is pale yellow to white before any reaction occurs.

Melting point (Celsius)
242.00
Melting point (Kelvin)
515.15
Boiling point (Celsius)
376.00
Boiling point (Kelvin)
649.15
General information
Molecular weight
178.15g/mol
Molar mass
178.1450g/mol
Density
1.6250g/cm3
Appearence

Ninhydrin is typically a pale yellow or white crystalline solid. It presents itself in a powdered form and is known for its vibrant blue or purple color when it reacts with amino acids, a useful property for fingerprint detection.

Comment on solubility

Solubility of 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid

The compound 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid, with the chemical formula C9H6O4, exhibits unique solubility characteristics that are important for its applications in various fields. Understanding the solubility behavior of this acid can provide insights into its reactivity and potential interactions in different environments.

Factors Influencing Solubility

Several factors can influence the solubility of this compound:

  • Polarity: The presence of polar functional groups, such as carboxylic acid (–COOH), enhances its ability to dissolve in polar solvents like water.
  • Hydrogen Bonding: The potential for hydrogen bonding allows for better interaction with solvent molecules, thereby increasing solubility in appropriate media.
  • Temperature: Higher temperatures generally lead to increased solubility for many organic compounds, which can also be true for this acid.

Solubility in Different Solvents

This compound is expected to have varying degrees of solubility in different solvents:

  • Aqueous Solutions: Likely to be soluble due to the carboxylic acid functional group facilitating interaction with water.
  • Organic Solvents: May show increased solubility in organic solvents with moderate to high polarity, such as DMSO or methanol.
  • Non-Polar Solvents: Limited solubility is expected in non-polar solvents like hexane, due to the overall polarity of the compound.

Conclusion

In conclusion, the solubility of 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid is influenced by several factors, primarily its polarity and the nature of the solvent. As such, understanding its solubility profile is crucial for predicting its behavior in biological and chemical systems.

Interesting facts

Interesting Facts About 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic Acid

2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid is a fascinating compound that blends structural complexity with promising biological activity. Below are some intriguing points about this remarkable molecule:

  • Structural Intricacies: This compound features a unique dioxobenzo framework that incorporates elements of isoquinoline chemistry. The integration of these functional groups contributes to its diverse chemical properties.
  • Biological Significance: Compounds similar to 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid have shown potential in medicinal chemistry, especially in the fields of anticancer and anti-inflammatory research.
  • Enzymatic Interactions: This molecule may influence various biological pathways by acting as an enzyme inhibitor. Its ability to modulate enzyme activity makes it a valuable candidate for further pharmacological studies.
  • Synthetic Approaches: The synthesis of this compound can involve multi-step reactions which often yield a variety of intermediates, making it an appealing target for organic chemists looking to explore novel reaction mechanisms.
  • Potential Applications: Beyond its potential in drug development, this compound may also find uses in materials science due to its intriguing electronic and optical properties.

In summary, 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid stands as a testament to the complexity and elegance of chemical compounds. Its intriguing structural features and the potential for biological applications invite further investigation and exploration in both synthetic and applied chemistry.

Synonyms
alrestatin
51411-04-2
Alrestatine
Alrestatin [INN]
Alrestatino
Alrestatinum
2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetic acid
Alrestatine [INN-French]
Alrestatinum [INN-Latin]
Alrestatin free acid
Alrestatino [INN-Spanish]
(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetic acid
2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid
Alrestatina
1,3-Dioxo-1H-benz(de)isoquinoline-2(3H)-acetic acid
NSC 299132
NSC-299132
BRN 0244370
515DHK15LG
AY-22284
DTXSID7045655
Spectrum_001449
Tocris-0485
(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetic acid
1,3-Dioxo-1H-benz(de)isoquinoline-2(3H)-acetate
ALRESTATIN [WHO-DD]
CHEMBL63055
2,3-Dihydro-1,3-dioxo-1H-benz(de)isochiolin-2-essigsaeure
DTXCID5025655
51411-04-2 (free acid)
4-21-00-05562 (Beilstein Handbook Reference)
NSC299132
1H-Benz(de)isoquinoline-2(3H)-acetic acid, 1,3-dioxo-
NCGC00024613-01
Alrestatine (INN-French)
Alrestatinum (INN-Latin)
Alrestatino (INN-Spanish)
1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid
1H-BENZ(DE)ISOQUINOLINE-2(3H)ACETIC ACID, 1,3-DIOXO-
2-{2,4-dioxo-3-azatricyclo[7.3.1.0,5,13]trideca-1(13),5,7,9,11-pentaen-3-yl}acetic acid
CAS-51411-04-2
SR-01000597621
2-(1,3-dioxobenzo(de)isoquinolin-2-yl)acetic acid
UNII-515DHK15LG
Alrestatin?
2-[1,3-DIOXO-1H-BENZO[DE]ISOQUINOLIN-2(3H)-YL]ACETIC ACID
AY 22,284
2-(2,4-dioxo-3-azatricyclo(7.3.1.0,5,13)trideca-1(13),5,7,9,11-pentaen-3-yl)acetic acid
MFCD00181399
SpecPlus_000666
Spectrum3_001880
Spectrum4_000089
Spectrum5_001248
BSPBio_001144
BSPBio_003360
CBDivE_001884
CBDivE_003810
CBDivE_004382
KBioGR_000358
KBioGR_000484
KBioSS_000484
KBioSS_001929
DivK1c_006762
SCHEMBL450743
BDBM16415
KBio1_001706
KBio2_000484
KBio2_001929
KBio2_003052
KBio2_004497
KBio2_005620
KBio2_007065
KBio3_000887
KBio3_000888
KBio3_002862
GCUCIFQCGJIRNT-UHFFFAOYSA-N
Bio2_000412
Bio2_000892
HMS1362J05
HMS1792J05
HMS1990J05
HMS2092B18
HMS3266E14
HMS3403J05
HMS3411O19
HMS3675O19
HMS3866E03
Pharmakon1600-01502053
BCA41104
BCP28030
EX-A2966
HY-B1202
Tox21_110913
NSC758180
s5803
STK395007
AKOS000143709
Tox21_110913_1
CCG-109865
CS-4830
DB02020
NSC-758180
IDI1_002167
NCGC00024613-02
NCGC00024613-03
NCGC00024613-04
NCGC00024613-06
AC-13697
AC-35588
AY22,284
BS-16959
SBI-0051717.P003
DB-051958
NS00069482
D81785
EN300-235766
AB00052267-02
AB00052267_03
AF-399/32018005
Q4735714
SR-01000597621-1
SR-01000597621-2
BRD-K35498378-001-03-8
BRD-K35498378-001-05-3
BRD-K35498378-001-06-1
BRD-K35498378-001-07-9
Z56756231
AY-22284 pound>> AY22284 pound>> AY 22284
F0863-0248
2-{2,4-dioxo-3-azatricyclo[7.3.1.0;{5,13}]trideca-1(12),5,7,9(13),10-pentaen-3-yl}acetic acid
853-081-7