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N-Phthaloylglycine

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Identification
Molecular formula
C10H8N2O3
CAS number
81-65-2
IUPAC name
2-(1,3-dioxoisoindolin-2-yl)acetamide
State
State

At room temperature, N-Phthaloylglycine is a solid. It is stable under standard conditions but may undergo changes under extreme conditions.

Melting point (Celsius)
189.50
Melting point (Kelvin)
462.65
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
204.18g/mol
Molar mass
203.1740g/mol
Density
1.4400g/cm3
Appearence

N-Phthaloylglycine appears as a white to off-white crystalline powder. It is generally odorless and has a solid crystalline appearance, indicating its high purity.

Comment on solubility

Solubility of 2-(1,3-dioxoisoindolin-2-yl)acetamide

The solubility of 2-(1,3-dioxoisoindolin-2-yl)acetamide can be influenced by various factors, predominantly its chemical structure which incorporates an isoindoline core. Understanding the solubility characteristics is critical for its applications in pharmaceuticals and materials science.

Key Factors Affecting Solubility:

  • Polarity: The presence of polar functional groups, such as the amide group, enhances interactions with polar solvents like water.
  • Hydrogen Bonding: The ability of 2-(1,3-dioxoisoindolin-2-yl)acetamide to form hydrogen bonds can significantly affect its solubility in both organic and aqueous solvents.
  • Temperature: Increasing temperature typically increases the solubility of solids in liquids, which is vital when handling this compound.
  • pH Levels: The solubility may vary with the pH of the solution, especially in cases where ionization plays a role.

General observations suggest that compounds with similar structure may have moderate solubility in organic solvents, while solubility in water can be limited. As with many aromatic compounds, it is essential to conduct specific solubility tests tailored to the desired solvent system to accurately define its behavior.

In conclusion, although detailed solubility data for 2-(1,3-dioxoisoindolin-2-yl)acetamide may be limited, emphasis should be placed on variables such as polarity and temperature when predicting its solubility in various environments.

Interesting facts

Interesting Facts about 2-(1,3-Dioxoisoindolin-2-yl)acetamide

2-(1,3-Dioxoisoindolin-2-yl)acetamide is a fascinating compound that has drawn attention in various fields of research, particularly in medicinal chemistry and organic synthesis. Here are some intriguing aspects of this unique molecule:

  • Structural Complexity: This compound features a unique isoindoline framework, which is notable for its fused ring structure. The incorporation of a dioxo moiety adds to its structural diversity, making it a point of interest for chemists.
  • Potential Biological Activity: Derivatives of isoindoline compounds have been explored for their potential therapeutic properties, including anti-cancer and anti-inflammatory activities. Researchers are keen to investigate how modifications like those seen in this compound can enhance biological efficacy.
  • Synthesis Opportunities: The synthesis of 2-(1,3-dioxoisoindolin-2-yl)acetamide can serve as a valuable exercise in organic chemistry laboratories. It introduces students and researchers alike to a variety of reaction mechanisms and condensation reactions.
  • Interdisciplinary Applications: Beyond organic chemistry, the compound's structure makes it relevant in fields such as materials science and pharmacology. Understanding its properties can drive innovations in developing new materials or drugs.
  • Quote from a Chemist: “Compounds with complex ring structures often harbor unexpected properties that can lead to breakthroughs in material science and pharmaceuticals.” – Anonymous

In conclusion, 2-(1,3-Dioxoisoindolin-2-yl)acetamide exemplifies a unique blend of structural sophistication and potential utility, providing ample opportunities for exploration and discovery within the scientific community.

Synonyms
2-Phthalimidoacetamide
1,3-Dihydro-1,3-dioxo-2H-isoindole-2-acetamide
653-844-2
4935-96-0
N-Phthalylglycinamide
N-Phthaloylglycinamide
2-(1,3-Dioxoisoindolin-2-yl)acetamide
Acetamide, 2-phthalimido-
Phthalimide, N-(carbamoylmethyl)-
2-ISOINDOLINEACETAMIDE, 1,3-DIOXO-
2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetamide
2-(1,3-dioxoisoindol-2-yl)acetamide
2H-Isoindole-2-acetamide, 1,3-dihydro-1,3-dioxo-
NSC-45851
n-Phthaloylglycineamide
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
NSC 45851
BRN 0384143
phthalimidoacetic acid amide
Oprea1_453186
5N3QV39Q7P
SCHEMBL3281797
2-Isoindolineacetamide,3-dioxo-
DTXSID90197776
OGDWOTGXUXNSQA-UHFFFAOYSA-N
2H-Isoindole-2-acetamide, 1,3-dihydro-1,3-dioxo- (9CI)
HMS1760D07
NSC45851
STL576993
AKOS001061515
DS-004138
EU-0017591
2H-Isoindole-2-acetamide,3-dihydro-1,3-dioxo-
AG-205/15424404
Z18271715
2H-isoindole-2-acetamide, 1,3-dihydro-1,3-dioxo-(9ci)