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2-(1,3,4-oxadiazol-2-yl)phenol

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Identification
Molecular formula
C8H6N2O2
CAS number
56238-65-2
IUPAC name
2-(1,3,4-oxadiazol-2-yl)phenol
State
State

At room temperature, 2-(1,3,4-Oxadiazol-2-yl)phenol exists in a crystalline solid state. Its aromatic and heterocyclic molecular structure contributes to its stability as a solid under standard conditions.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
335.00
Boiling point (Kelvin)
608.15
General information
Molecular weight
176.15g/mol
Molar mass
176.1630g/mol
Density
1.2543g/cm3
Appearence

2-(1,3,4-Oxadiazol-2-yl)phenol typically appears as a pale yellow crystalline solid. The compound's structure features a hydroxyl group attached to a phenyl ring that is also connected to a 1,3,4-oxadiazole ring, imparting a unique structural and electronic configuration. The appearance might vary slightly based on purity and form (e.g., powder vs. crystallized form).

Comment on solubility

Solubility of 2-(1,3,4-oxadiazol-2-yl)phenol

The solubility of 2-(1,3,4-oxadiazol-2-yl)phenol can be influenced by several factors, including its molecular structure, the presence of functional groups, and the solvent used. This compound features both an oxadiazole group and a phenolic moiety, which can interact with solvents in distinct ways.


Key Points About Solubility:

  • Polarity: The presence of polar functional groups, such as the hydroxyl group (-OH) in phenol, typically enhances the solubility of a compound in polar solvents like water.
  • Hydrogen Bonding: Hydrogen bonding plays a crucial role; the ability of 2-(1,3,4-oxadiazol-2-yl)phenol to form hydrogen bonds can increase solubility in water.
  • Solvent Compatibility: This compound may exhibit varying solubility in different organic solvents such as ethanol, methanol, or acetone.
  • Temperature Effects: Solubility may increase with temperature, making it more soluble in warm solvents.
  • Behavior in Aqueous Solutions: It is also important to consider how the compound interacts in aqueous environments, which can be critical for biological applications.

In summary, the solubility of 2-(1,3,4-oxadiazol-2-yl)phenol is likely influenced by its polar characteristics and ability to engage in hydrogen bonding. The specific solubility behavior would depend on the solvent conditions, requiring assessment on a case-by-case basis for practical applications.

Interesting facts

Exploring 2-(1,3,4-oxadiazol-2-yl)phenol

2-(1,3,4-oxadiazol-2-yl)phenol is a fascinating compound known for its diverse applications and unique structural attributes. This compound showcases the marriage of pharmacology and material science, making it an important subject of investigation in both fields.

Key Features:

  • Pharmacological Potential: The oxadiazole ring in the compound contributes to its biological activity, with many derivatives showing anti-inflammatory and antimicrobial properties.
  • Versatile Applications: This compound has been explored in various applications, including drug development and as a building block in organic synthesis.
  • Research Significance: Studies have shown that the incorporation of oxadiazole into phenolic structures can enhance their effectiveness as chemotherapeutic agents.

As an aromatic compound, the presence of both the phenolic group and the oxadiazole moiety enhances its electronic properties. This synergy can lead to interesting characteristics that are useful in creating new materials with enhanced performance.

Interesting Insights:

  • The unique blend of permeability and reactive sites makes 2-(1,3,4-oxadiazol-2-yl)phenol a promising candidate in drug design and molecular biology.
  • Researchers often utilize reactions such as cyclization and coupling to synthesize derivatives that could provide better yield and efficacy in desired functions.
  • The study of this compound can expose students to the intricate techniques of organic synthesis and the importance of structural modifications in developing effective therapies.

In conclusion, the exploration of 2-(1,3,4-oxadiazol-2-yl)phenol not only embodies fundamental chemical principles but also supports innovations in medicine and materials science. As research continues, it may reveal even more applications and insights into the potential of oxadiazole derivatives in various scientific domains.

Synonyms
2-(1,3,4-Oxadiazol-2-yl)phenol
Fenadiazole
Fenadiazol
Eudormil
Hypnazol
Viodor
Fenadiazolum
JL 512
o-1,3,4-Oxadiazol-2-ylphenol
PHENOL, 2-(1,3,4-OXADIAZOL-2-YL)-
Phenol, o-1,3,4-oxadiazol-2-yl-
J. L. 512
Fenadiazole [INN:DCF]
Fenadiazol [INN-Spanish]
Fenadiazolum [INN-Latin]
2-(o-Hydroxyphenyl)-1,3,4-oxadiazole
NSC 100729
UNII-8YX6HIZ0IP
8YX6HIZ0IP
1,3,4-Oxadiazole, 2-(o-hydroxyphenyl)-
JL-512
NSC-100729
BRN 0136925
DTXSID7057608
FENADIAZOLE [MI]
FENADIAZOLE [INN]
DTXCID5031397
o-1,3,4-Oxodiazol-2-ylphenol
CHEBI:134791
4-27-00-07344 (Beilstein Handbook Reference)
2-(1,3,4-Oxadiazol-2-yl)-phenol
Fenadiazol (INN-Spanish)
Fenadiazolum (INN-Latin)
Phenol, o-1,3,4-oxadiazol-2-yl-(8CI)
680-965-8
oinxxhyenyvypb-uhfffaoysa-n
1008-65-7
2-(1,3,4-oxadiazol-2-yl)benzenol
MLS002703546
MFCD00020713
o-1,4-Oxadiazol-2-ylphenol
SCHEMBL555484
Phenol,3,4-oxadiazol-2-yl-
IFLab1_006238
IFLab2_000252
CHEMBL1903897
Phenol,3,4-oxadiazol-2-yl)-
2-(1,4-Oxadiazol-2-yl)phenol
HMS1429L12
BAA00865
Tox21_113759
NSC100729
STK409833
2-(o-Hydroxyphenyl)-1,4-oxadiazole
ortho-1,3,4-Oxadiazol-2-yl-phenol
AKOS000269733
SDCCGMLS-0065586.P001
IDI1_019278
1,4-Oxadiazole, 2-(o-hydroxyphenyl)-
2-(2-hydroxyphenyl)-1,3,4-oxadiazole
NCGC00253631-01
SMR001570263
CAS-1008-65-7
DB-058510
HY-115139
CS-0034608
NS00126328
EN300-110858
10A-002
AT-057/42646623
Q5442960
BRD-K18362446-001-06-8
Z57438332