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Dexamethasone acetate

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Identification
Molecular formula
C24H31FO6
CAS number
1177-87-3
IUPAC name
[2-[(16R,17R)-17,20-dihydroxy-2,11,16,18-tetramethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9,11-tetraen-17-yl]-2-oxo-ethyl] acetate
State
State
At room temperature, dexamethasone acetate is a solid in crystalline form.
Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
214.00
Boiling point (Kelvin)
487.15
General information
Molecular weight
472.53g/mol
Molar mass
472.5320g/mol
Density
1.3000g/cm3
Appearence
Dexamethasone acetate appears as a white to off-white crystalline powder. It is practically odorless.
Comment on solubility

Solubility of 2-[(16R,17R)-17,20-dihydroxy-2,11,16,18-tetramethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9,11-tetraen-17-yl]-2-oxo-ethyl Acetate

The solubility of complex organic compounds, such as 2-[(16R,17R)-17,20-dihydroxy-2,11,16,18-tetramethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9,11-tetraen-17-yl]-2-oxo-ethyl acetate, can be influenced by several factors, which include:

  • Polarity: The presence of hydroxyl groups and acetate functionality can increase the compound's ability to dissolve in polar solvents, such as water.
  • Hydrophobicity: The bulky hydrophobic steroid-like structure may lead to limited solubility in aqueous environments, but it could show better solubility in non-polar organic solvents.
  • Temperature: Generally, increasing temperature enhances solubility for many compounds; therefore, heating may facilitate the dissolution of this complex molecule.
  • Persistent interactions: Van der Waals forces, hydrogen bonding, and steric effects might hinder proper solvation, affecting overall solubility.

In summary, while the solubility of this compound might present challenges due to its intricate structure, it holds potential for solubility in specific environments, particularly when considering solvent choice and temperature adjustments to optimize its dissolution.

Interesting facts

Interesting Facts about 2-[(16R,17R)-17,20-Dihydroxy-2,11,16,18-tetramethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9,11-tetraen-17-yl]-2-oxo-ethyl Acetate

This compound, known for its complex structure and potential biological activity, is a derivative of a specific class of nitrogen-containing compounds that exhibit intriguing properties. Here are some fascinating points to consider:

  • Natural Product Inspiration: Many compounds like this one are often derived from natural products and may mimic the structures of various biologically active molecules found in nature.
  • Complex Structure: With its pentacyclic framework and multiple chiral centers, this compound exemplifies the vast complexity found in organic chemistry, showcasing how intricate molecular shapes can influence function.
  • Potential Applications: Compounds of this class have shown a variety of pharmacological activities, which may include antibacterial, antifungal, and anticancer properties. Research in medicinal chemistry often seeks to explore these aspects further.
  • Synthesis Challenges: The synthesis of such complex molecules poses numerous challenges, including the need for precise control over stereochemistry and functional group positioning, which can truly test a chemist's skills.
  • Interdisciplinary Interest: Aspects of this compound cross multiple disciplines, including organic chemistry, medicinal chemistry, and pharmacology, making it an interesting subject for collaborative research.

In summary, compounds like this one not only reflect the beauty of chemical ingenuity but also underscore the potential they hold for future therapeutic advancements. As chemists delve deeper into studying and synthesizing these complex compounds, they continue to unravel mysteries that may lead to groundbreaking discoveries in medicine and beyond.