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Dexamethasone acetate

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Identification
Molecular formula
C24H31F2O6
CAS number
1177-87-3
IUPAC name
[2-(17-acetoxy-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate
State
State

Dexamethasone acetate is in a solid state at room temperature, typically presented as a crystalline powder.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
385.60
Boiling point (Kelvin)
658.80
General information
Molecular weight
434.52g/mol
Molar mass
434.5170g/mol
Density
1.2500g/cm3
Appearence

Dexamethasone acetate typically appears as a white to practically white crystalline powder. It is odorless or may have a slight odor.

Comment on solubility

Solubility of [2-(17-acetoxy-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate

The solubility characteristics of the compound C24H31F2O6 can be quite intriguing. Understanding solubility is crucial for predicting its behavior in different environments and its potential applications. Here are some key points concerning its solubility:

  • Polar vs. Nonpolar: The presence of the functional groups such as acetoxy and hydroxyl groups suggests a certain degree of polarity, which often enhances solubility in polar solvents like water and alcohol.
  • Hydrophobic Nature: The multi-ring structure and hydrocarbon portions may impart a hydrophobic aspect, making it less soluble in water.
  • Common Solvents: Typically, compounds with this type of molecular structure may dissolve better in organic solvents, such as ethyl acetate or dichloromethane.
  • Influence of Temperature: Solubility can vary with temperature; generally, higher temperatures may increase solubility in organic solvents.
  • Concentration Impact: The solubility may also depend on concentration levels and the potential for supersaturation in solutions.

In summary, the solubility profile for this compound is influenced by its complex structure and the balance between hydrophilic and hydrophobic characteristics. As such, experimentation in relevant solvents is invaluable for a precise understanding. It is essential to remember that “like dissolves like,” meaning polar solvents will more effectively solvate polar compounds, while nonpolar solvents will favor nonpolar solutes.

Interesting facts

Interesting Facts About 2-(17-acetoxy-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl Acetate

This complex compound is part of a larger class of biologically active molecules known for their potential therapeutic properties. Here are some intriguing insights into this compound:

  • Structural Complexity: The molecular structure includes multiple functional groups and a notable steric configuration, which can greatly influence its biological activity and interaction with other molecules.
  • Fluorinated Derivatives: The presence of fluorine atoms can enhance the compound's metabolic stability and lipophilicity, making it particularly interesting in medicinal chemistry. Fluorinated compounds often exhibit altered pharmacokinetics.
  • Potential Therapeutic Uses: Compounds like this are often investigated for their anti-inflammatory, anti-cancer, or hormone-regulating effects, demonstrating the significance of such chemical structures in developing new treatments.
  • Synthetic Routes: The synthesis of such compounds can involve intricate multi-step reactions, making it a captivating topic for organic chemists who appreciate the nuances of reaction mechanisms and yield optimization.
  • Stability and Storage: Given the nature of its functional groups, understanding how to stabilize this compound during storage and handling is critical. Certain conditions can lead to degradation, impacting its efficacy in pharmacological settings.

As researchers continue to explore the medicinal capabilities of compounds like 2-(17-acetoxy-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl acetate, they shed light on novel applications that can potentially enhance human health.

In the words of chemist Richard Feynman, "There is no law that says you cannot make something interesting out of something that is not interesting." Through such complex compounds, we are continually reminded of the beauty and intricacy of chemistry.

Synonyms
Psorcon
[2-(17-acetyloxy-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] acetate
Dermaflor
Diacort
Difulal
Soriflor
CHEMBL4777053
DTXSID40860488
BOBLHFUVNSFZPJ-UHFFFAOYSA-N
BCP21788
Pregna-1,4-diene-3,20-dione, 17,21-bis(acetyloxy)-6,9-difluoro-11-hydroxy-16-methyl-, (6.alpha.,11.beta.,16.beta.)-
DB-048444
NS00076915
U-24865
6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate
(6.alpha.,11.beta.,16.beta.)-17,21-Bis(acetyloxy)-6,9-difluoro-11-hydroxy-16-methyl-pregna-1,4-diene-3,20-dione
17-(Acetyloxy)-6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate-, (6.alpha.,11.beta.,16.beta.)-
6.alpha.,9-Difluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-diacetate