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Dexamethasone phosphate

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Identification
Molecular formula
C22H30FO8P
CAS number
55203-24-2
IUPAC name
[2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate
State
State

At room temperature, dexamethasone phosphate is typically in a solid crystalline state. It is commonly administered in aqueous solutions due to its high solubility in water.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
235.00
Boiling point (Kelvin)
508.15
General information
Molecular weight
516.41g/mol
Molar mass
472.4040g/mol
Density
1.4245g/cm3
Appearence

Dexamethasone phosphate typically appears as a white or almost white, crystalline powder. It is very soluble in water, and only slightly soluble in alcohol and chloroform.

Comment on solubility

Solubility of 2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl dihydrogen phosphate

The compound 2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl dihydrogen phosphate is an intriguing chemical due to its solubility properties.

In general, the solubility of compounds like this one can be influenced by several factors:

  • Polarity: Compounds that have polar functional groups, such as dihydroxy or phosphate groups, tend to exhibit better solubility in polar solvents like water.
  • Hydrogen Bonding: The presence of hydroxyl groups can facilitate hydrogen bonding with solvent molecules, enhancing solubility.
  • Molecular Size: Larger and more complex structures might pose challenges in solubility due to increased van der Waals interactions.

However, due to the complexity and size of this molecule, predicting solubility can be challenging. It is often useful to consider the following aspects:

  1. Test solubility in various solvents—water, ethanol, and dimethyl sulfoxide (DMSO).
  2. Check for potential interactions with other molecules that could alter solubility.
  3. Perform computational modeling to predict solubility behavior based on the molecular structure.

In conclusion, while the specific solubility of this compound might require experimental validation, its hydrophilic and structural characteristics suggest that it may be reasonably soluble in polar solvents, particularly those capable of hydrogen bonding.

Interesting facts

Interesting Facts about 2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl dihydrogen phosphate

This compound is a fascinating example of the intersection between biochemistry and pharmacology. Here are some key highlights:

  • Structural Complexity: The compound features a multi-ring structure typical of steroid derivatives, making it part of a class that often plays significant roles in biological systems.
  • Biological Importance: Dihydroxy steroids are known to interact with hormonal pathways, which can have implications in areas such as metabolism, growth, and reproduction.
  • Potential Pharmacological Effects: Compounds like this one may exhibit properties beneficial in therapeutic contexts, particularly in hormone replacement therapies or as anti-inflammatory agents.
  • Research Interest: Due to its complex biological activities, ongoing research might focus on understanding its mechanism of action and potential applications in treating hormone-dependent diseases.
  • Chemical Modifications: The presence of phosphate groups in the structure suggests that modifications and derivatives could lead to compounds with varied bioactivities or improved stability.

As a scientist, one cannot help but admire the ingenuity of nature and the synthetic expertise required to create such a complex molecule. The intricate way in which slight alterations in configuration can lead to significantly different biological outcomes is a captivating aspect of medicinal chemistry. This compound serves as a reminder of the vast potential hidden within organic compounds to influence life processes.

In the words of Louis Pasteur, “Chance favors the prepared mind.” This reflects the diligent research often underpinning the discovery of new compounds and their potential uses in health and medicine.

Synonyms
[2-[(11S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] dihydrogen phosphate
CHEMBL419250