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Betamethasone valerate

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Identification
Molecular formula
C27H37FO6
CAS number
2152-44-5
IUPAC name
[2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] butanoate
State
State

Betamethasone valerate is typically found in a solid state at room temperature.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
457.40
Boiling point (Kelvin)
730.50
General information
Molecular weight
476.58g/mol
Molar mass
476.5780g/mol
Density
1.1871g/cm3
Appearence

Betamethasone valerate appears as a white to creamy-white crystalline powder.

Comment on solubility

Solubility of 2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl butanoate

The solubility of 2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl butanoate is influenced by several factors reflecting its complex structure.

  • Polarity: Due to the presence of hydroxyl groups (-OH) and ester formations, this compound exhibits varying levels of polarity, which may enhance its solubility in polar solvents like water.
  • Hydrophobic Character: The large cyclic and hydrophobic hydrocarbon portions suggest a lower solubility in aqueous environments but favor solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).
  • Temperature: Solubility can often increase with temperature; therefore, heating may enhance the dissolution rate in appropriate solvents.

Interestingly, the compound's solubility could be described as moderate; while it is somewhat soluble in organic solvents, its solubility in water might be limited. As a result, it would be wise to explore various solvents to define its solubility parameters effectively. In summary, the solubility behavior of this compound is determined by a balance of polarity and hydrophobic character, making it essential to consider the solvent environment when performing experiments.

Interesting facts

Interesting Facts about 2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl butanoate

This compound is part of a class of chemicals known for their complex molecular structures and potential biological activities. Here are some compelling insights into this fascinating substance:

  • Biochemical Relevance: This compound may play a role in various biochemical pathways, especially regarding steroidal hormones due to its structural similarity to steroids. It could be significant in understanding hormone regulation.
  • Physiological Effects: Compounds with similar structures have shown varying physiological effects. A noteworthy consideration is their potential therapeutic applications, which may include anti-inflammatory or anabolic activity.
  • Synthetic Challenges: The synthesis of such complex molecules often presents challenges. Chemists need to employ advanced techniques and reagents, making the study of these compounds both challenging and intriguing.
  • Cyclopenta[a]phenanthrene Framework: The unique framework of this compound is derived from a fused polycyclic structure, making it a subject of interest in organic chemistry and medicinal chemistry.
  • Chirality: The compound contains stereocenters, specifically at the 17-position, creating chirality that can significantly affect its pharmacological properties and interactions within biological systems.

In conclusion, the complexity and potential applications of this compound make it a compelling topic for investigation in both academic and pharmaceutical research. The more we study such compounds, the closer we get to unlocking new avenues for therapeutic agents and understanding biochemical interactions.