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Dexamethasone phosphate

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Identification
Molecular formula
C22H29FO5P
CAS number
55203-24-2
IUPAC name
[2-[(17R)-17-hydroxy-10,13,16-trimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate
State
State

At room temperature, Dexamethasone phosphate is most commonly encountered in a solid crystalline state when isolated as a pure compound. It is often dissolved in solutions for medical usage.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
531.50
Boiling point (Kelvin)
804.65
General information
Molecular weight
516.42g/mol
Molar mass
516.4240g/mol
Density
1.4500g/cm3
Appearence

Dexamethasone phosphate is typically available in the form of white to off-white, crystalline powder. It might not have a distinct odor and is usually provided in a purified form as a salt in various pharmaceutical formulations, like tablets or injectable solutions.

Comment on solubility

Solubility of 2-[(17R)-17-hydroxy-10,13,16-trimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl dihydrogen phosphate

The solubility of this compound, known for its complex molecular structure, can be influenced by several factors. It is essential to consider the following aspects of solubility:

  • Polarity: The presence of the phosphate group may enhance its polar characteristics, likely allowing it to dissolve better in polar solvents such as water.
  • Functional Groups: The hydroxyl and carbonyl functional groups contribute to hydrogen bonding, which can improve solubility in various solvents.
  • Medium Conditions: The pH of the environment can play a crucial role in the solubility behavior. For example, under acidic conditions, the phosphate group could protonate, affecting solubility.

Also, as with many organic compounds, its solubility might show considerable variance depending on temperature and pressure. Always remember these nuances can provide insight into the compound's behavior in various applications, as stated: "The solubility is a fundamental property that influences the reactivity and biological activity of compounds."

In conclusion, while precise solubility data can often require empirical determination, understanding these factors provides a solid starting point for predicting the solubility of this intriguing chemical compound.

Interesting facts

Interesting Facts about 2-[(17R)-17-hydroxy-10,13,16-trimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl dihydrogen phosphate

This compound, known for its unique structural attributes, is a phosphate ester derived from steroid frameworks. Its complex architecture provides a fascinating insight into how modifications at various positions can affect the substance's biological activity.

Structural Highlights

  • Phosphate Group: The presence of a dihydrogen phosphate moiety plays a crucial role in the compound's reactivity and interaction with biomolecules.
  • Hydroxyl Functional Group: The hydroxyl group at the 17th position influences the compound's solubility and can significantly affect its pharmacokinetics.
  • Stability Factors: The numerous methyl groups contribute to the overall stability, which is essential for maintaining biological functionality.

Biological Significance

This compound is a part of a larger class of compounds that exhibit various biological activities, potentially serving as leads in drug discovery. Some notable points include:

  • Hormonal Activity: Given its steroid-like structure, it may interact with hormone receptors, leading to diverse physiological effects.
  • Therapeutic Potential: Compounds similar to this one have shown promise in numerous therapeutic applications, including anti-inflammatory and anticancer research.
  • Research Applications: Used as a model compound, it helps chemists understand the relationship between structure and function in complex biological systems.

Quotes from the Field

As one researcher puts it: "The intricate dance of atoms in these compounds reveals secrets that nature has perfected over millions of years." This highlights the continuing exploration of chemical significance in biology.

Ultimately, the examination of this compound and its analogs offers a glimpse into the vast possibilities that exist at the intersection of organic chemistry and pharmacology.