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Benzimidazole-2-acetic acid

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Identification
Molecular formula
C9H8N2O2
CAS number
5802-95-7
IUPAC name
2-(1H-benzimidazol-2-yl)acetic acid
State
State

The compound is typically found as a solid at room temperature, indicating its crystalline and stable nature.

Melting point (Celsius)
260.00
Melting point (Kelvin)
533.15
Boiling point (Celsius)
511.90
Boiling point (Kelvin)
785.05
General information
Molecular weight
176.18g/mol
Molar mass
176.1820g/mol
Density
1.3600g/cm3
Appearence

Benzimidazole-2-acetic acid presents as a white or off-white crystalline powder, highlighting its purity and fine granularity.

Comment on solubility

Solubility of 2-(1H-benzimidazol-2-yl)acetic acid

The solubility of 2-(1H-benzimidazol-2-yl)acetic acid in various solvents can be quite intriguing and deserves detailed examination. This compound, characterized by its aromatic and polar functional groups, exhibits unique solubility properties.


Factors Affecting Solubility

Several factors influence the solubility of this compound:

  • Polarity: The presence of the carboxylic acid group enhances polarity, promoting solubility in polar solvents like water.
  • Hydrogen Bonding: The benzimidazole ring can participate in hydrogen bonding, which can further facilitate interactions with polar solvents.
  • Temperature: Like many organic compounds, increased temperature typically enhances solubility.

Solubility Profile

While specific solubility data may vary, it is generally observed that:

  • Water: 2-(1H-benzimidazol-2-yl)acetic acid has reasonable solubility in water due to its acidic functional group.
  • Organic Solvents: It can also dissolve in organic solvents such as DMSO and ethanol, which are less polar than water but can still solvate this compound effectively.

In summary, understanding the solubility characteristics of 2-(1H-benzimidazol-2-yl)acetic acid is essential for its chemical applications and can guide the choice of solvents in various experimental setups. As a rule of thumb, polar solvents will generally favor the solubility of this compound.

Interesting facts

Interesting Facts about 2-(1H-benzimidazol-2-yl)acetic acid

2-(1H-benzimidazol-2-yl)acetic acid is a fascinating compound that belongs to a class of organic compounds known as benzimidazoles. This compound has garnered attention in both pharmaceutical chemistry and materials science due to its unique structural features and diverse biological activities.

Biological Significance

One of the most notable aspects of 2-(1H-benzimidazol-2-yl)acetic acid is its potential biological applications:

  • Antimicrobial Activity: Researchers have found that this compound exhibits antimicrobial properties, making it a candidate for the development of new antibacterial agents.
  • Anti-inflammatory Effects: Preliminary studies suggest that the compound may also possess anti-inflammatory benefits, which could contribute to therapeutic strategies for inflammatory diseases.
  • Potential Anticancer Properties: Some investigations indicate that benzimidazole derivatives might play a role in cancer treatment, offering hope in the search for novel anticancer drugs.

Chemical Structure and Properties

The unique structure of this compound is characterized by:

  • Benzimidazole Ring: The inclusion of a benzimidazole moiety contributes to the compound’s chemical stability and reactivity.
  • Acetic Acid Functional Group: The presence of an acetic acid group facilitates interactions with biological targets, enhancing its activity.

Applications in Research

In addition to its potential medicinal applications, 2-(1H-benzimidazol-2-yl)acetic acid is often studied for:

  • Synthesis of New Compounds: It serves as a versatile building block for synthesizing other complex molecules.
  • Investigations in Material Science: This compound can be utilized in the development of novel materials with specialized properties.

As scientists delve deeper into the properties and applications of 2-(1H-benzimidazol-2-yl)acetic acid, it is likely that more exciting discoveries will emerge, reinforcing its significance in both the medicinal and chemical realms.

Synonyms
13570-08-6
1H-Benzimidazole-2-acetic acid
2-BENZIMIDAZOLEACETIC ACID
Acetic acid, 2-benzimidazol-2-yl-
2-(Carboxymethyl)benzimidazole
NSC 525202
BRN 0153484
1H-Benzimidazole-2-acetic acid (9CI)
DTXSID70159498
5-25-04-00285 (Beilstein Handbook Reference)
2-(1H-Benzo[d][1,3]diazol-2-yl)acetic acide
2-(1H-Benzo(d)(1,3)diazol-2-yl)acetic acide
DTXCID4081989
GFTPLFVZKMIYAP-UHFFFAOYSA-N
(1H-Benzoimidazol-2-yl)-acetic acid
2-(1H-Benzo[d]imidazol-2-yl)acetic acid
2-(1H-benzimidazol-2-yl)acetic acid
1H-Benzimidazol-2-ylacetic acid
(1H-Benzoimidazol-2-yl)acetic acid
MFCD01102656
2-(1H-1,3-Benzodiazol-2-Yl)Acetic Acid
DJU8LFP9EA
NSC-525202
2-benzimidazol-2-ylacetic acid
(1H-Benzimidazol-2-yl)acetic acid
UNII-DJU8LFP9EA
ChemDiv3_007143
SCHEMBL761148
2-(2-Benzoimidazolyl)acetic Acid
HMS1493E15
1H-Benzimidazol-2-ylacetic acid #
ALBB-022312
BBL033744
GEO-02600
NSC525202
SBB039829
STL163377
AKOS000271016
(1 h-benzoimidazol-2-yl)-acetic acid
AB08273
FS-1876
IDI1_025053
2-(1H-benzoimidazol-2-yl)-acetic acid
2-(1H-Benzo[d]imidazol-2-yl)aceticacid
SY122811
2-(1H-benzo[d]imidazole-2-yl)acetic acid
DB-016240
CS-0037477
ST50109073
2-(1H-1,3-BENZIMIDAZOL-2-YL)ACETIC ACID