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2-(1H-benzimidazol-2-yl)acetonitrile

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Identification
Molecular formula
C9H7N3
CAS number
56145-00-9
IUPAC name
2-(1H-benzimidazol-2-yl)acetonitrile
State
State

This compound is a solid at room temperature.

Melting point (Celsius)
154.00
Melting point (Kelvin)
427.15
Boiling point (Celsius)
369.00
Boiling point (Kelvin)
642.15
General information
Molecular weight
157.17g/mol
Molar mass
157.1700g/mol
Density
1.2510g/cm3
Appearence

2-(1H-benzimidazol-2-yl)acetonitrile typically appears as a white to off-white crystalline powder. It may take on a slight yellowish hue depending on the purity and moisture content. The compound is generally noted for its fine crystalline structure.

Comment on solubility

Solubility Characteristics of 2-(1H-benzimidazol-2-yl)acetonitrile

2-(1H-benzimidazol-2-yl)acetonitrile is a notable compound with intriguing solubility properties. Understanding its solubility is essential for various applications, particularly in medicinal chemistry and material science. Here, we break down the solubility aspects of this compound:

  • Polarity: The presence of the benzimidazole moiety along with the acetonitrile group contributes to its overall polarity. This allows it to dissolve in some polar solvents.
  • Solvent Compatibility: It is primarily soluble in:
    • Dimethyl sulfoxide (DMSO)
    • Dimethylformamide (DMF)
    • Water (to a lesser extent)
  • Self-Association: Due to hydrogen bonding capabilities, there may be moments of self-association, which can hinder full dissolution in certain solvents.
  • Temperature Dependence: Like many organic compounds, the solubility can vary significantly with temperature, often increasing in warmer conditions.

In summary, understanding the solubility of 2-(1H-benzimidazol-2-yl)acetonitrile is crucial for optimizing its use in various applications. Its ability to interact with different solvents and its responsiveness to conditions highlight the need for careful experimental considerations when researching its behaviors.

Interesting facts

Interesting Facts about 2-(1H-benzimidazol-2-yl)acetonitrile

2-(1H-benzimidazol-2-yl)acetonitrile is a fascinating compound that captures the interest of many in the fields of medicinal chemistry and pharmaceuticals. This compound is a derivative of benzimidazole, a well-known bicyclic structure that plays a significant role in various biological activities.

Key Highlights

  • Pharmacological Properties: The benzimidazole moiety is recognized for its broad range of bioactive properties, including anti-cancer, anti-inflammatory, and anti-viral activities. Researchers are continually investigating its potential in drug development.
  • Versatility: Due to its structural features, 2-(1H-benzimidazol-2-yl)acetonitrile serves as a versatile building block in organic synthesis, allowing chemists to modify its structure for specialized applications.
  • Research Applications: Its unique combination of functional groups makes it a prime candidate for studies in areas such as coordination chemistry and sensor development.
  • Biological Relevance: Studies have shown its potential role in influencing cellular pathways, making it an exciting subject for ongoing pharmacological research.

Insights from Researchers

As noted by some researchers, "Compounds like 2-(1H-benzimidazol-2-yl)acetonitrile offer the potential for innovation in therapeutic agents by exploiting their unique structural attributes."

In summary, 2-(1H-benzimidazol-2-yl)acetonitrile is a compound rich in possibilities, holding promise in various scientific domains from drug discovery to advanced materials science. It continues to entice the curiosity of scientists striving to unfold its numerous applications.

Synonyms
4414-88-4
(2-Benzimidazolyl)acetonitrile
2-(Cyanomethyl)benzimidazole
1H-Benzimidazole-2-acetonitrile
2-Cyanomethylbenzimidazole
2-(1H-benzimidazol-2-yl)acetonitrile
2-(1H-benzo[d]imidazol-2-yl)acetonitrile
EINECS 224-574-9
0AN9A7OY6F
NSC 525203
BRN 0128461
(1H-Benzimidazol-2-yl)acetonitrile
UNII-0AN9A7OY6F
NSC-525203
DTXSID5063445
2-BENZIMIDAZOLACETONITRILE
5-25-04-00286 (Beilstein Handbook Reference)
2-CYANOMETHYLBENZ(D)IMIDAZOLE
1-H-BENZOIMIDAZOL-2-YL-ACETONITRILE
2-(1H-BENZO(D)IMIDAZOL-2-YL)ACETONITRILE
DTXCID6040292
224-574-9
bwovacaneivhst-uhfffaoysa-n
2-BENZIMIDAZOLEACETONITRILE
1H-Benzimidazol-2-ylacetonitrile
2-Benzimidazolylacetonitrile
2-Kyanmethylbenzimidazol
Benzimidazole, 2-cyanomethyl-
2-(1H-1,3-benzodiazol-2-yl)acetonitrile
Acetonitrile, 2-benzimidazolyl-
MFCD00005601
2-Kyanmethylbenzimidazol [Czech]
(1H-Benzoimidazol-2-yl)-acetonitrile
(Benzimidazol-2-yl)ethanenitrile
2-(Cyanomethyl)-1H-benzimidazole
Benzimidazolylacetonitrile
2-benzimidazol-2-ylethanenitrile
2-Kyanmethylbenzimidazol [Czech]
(1H-Benzoimidazol-2-yl)acetonitrile
Enamine_003017
benzimidazole-2-acetonitrile
Oprea1_467984
SCHEMBL76988
2-(benzimidazolyl)acetonitrile
WLN: T56 BM DNJ C1CN
HMS1402J03
ALBB-010071
STR02009
1H-Benzimidazol-2-ylacetonitrile #
GEO-00258
NSC525203
STK009078
(2-Benzimidazolyl)acetonitrile, 97%
AKOS000275416
CS-W008228
FS-1339
SB66431
AC-12169
BP-12402
SY020970
DB-013295
B2821
NS00031397
EN300-16951
I10068
SR-01000389032
SR-01000389032-1
Z56828358
F0266-2601