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Mebendazole

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Identification
Molecular formula
C16H13N3O3
CAS number
31431-39-7
IUPAC name
2-(1H-benzimidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine
State
State

Solid: At room temperature, mebendazole is in a solid state. It is usually distributed in tablet form for pharmaceutical use.

Melting point (Celsius)
288.00
Melting point (Kelvin)
561.00
Boiling point (Celsius)
435.09
Boiling point (Kelvin)
708.24
General information
Molecular weight
296.30g/mol
Molar mass
296.4000g/mol
Density
1.4900g/cm3
Appearence

Mebendazole is typically a white to slightly yellow powder. It can appear crystalline in nature, and it is odorless. The exact appearance can vary slightly depending on synthesis conditions and the presence of any impurities.

Comment on solubility

Solubility of 2-(1H-benzimidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine

The compound 2-(1H-benzimidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine exhibits unique solubility characteristics that are influenced by its structural components. Understanding its solubility can provide insights into its reactivity and potential applications.

Generally, solubility can be affected by several factors:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents, while non-polar segments promote solubility in non-polar solvents.
  • Hydrophobic and Hydrophilic Balance: The balance between hydrophilic (water-attracting) and hydrophobic (water-repellent) parts of the molecule determines its overall solubility in aqueous environments.
  • Temperature: Changes in temperature can influence solubility, as increased kinetic energy often enhances the dissolution process.

This specific compound contains both a benzimidazole moiety and an amine, which may suggest variable solubility profiles. As a rule of thumb:

  • Compounds with nitrogen-containing groups are often soluble in water due to their ability to form hydrogen bonds.
  • However, the dual ethyl groups can introduce steric hindrance, possibly reducing solubility.

As a result, predicting the exact solubility in different solvents requires empirical testing, but one might expect moderate solubility in polar solvents, potentially yielding insights into its behavioral characteristics in biological systems.

Interesting facts

Interesting Facts about 2-(1H-benzimidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine

The compound 2-(1H-benzimidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine, often referred to as a substituted benzimidazole derivative, presents a fascinating integration of organic chemistry and medicinal applications. Its unique structure embodies several noteworthy features:

  • Benzimidazole Basis: The benzimidazole moiety is renowned for its presence in various pharmaceutical agents, especially in anti-cancer and anti-parasitic drugs. This broad therapeutic relevance underscores the importance of studying compounds featuring this ring structure.
  • Role of Sulfur: The inclusion of a sulfanyl (-SH) group is significant because sulfur plays a key role in biological systems, including enzyme functions and redox reactions.
  • Diverse Applications: Due to its structural integrity, this compound may exhibit properties that are beneficial in multiple research domains, including biochemistry, pharmacology, and materials science.
  • Potential in Drug Development: With an increasing interest in compounds that can target specific biological pathways, the exploration of derivatives like this could lead to the development of novel therapeutics.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This compound inspires a curiosity-driven approach, encouraging scientists and chemistry students alike to explore its potential applications and contribute to the unfolding story of medicinal chemistry.

As research progresses, understanding the interactions and activities of such compounds enriches our knowledge, opening doors to innovative solutions in healthcare and industry.

Synonyms
25369-81-7
2-(1H-benzimidazol-2-ylsulfanyl)-N,N-diethylethanamine
BENZIMIDAZOLE, 2-((2-(DIETHYLAMINO)ETHYL)THIO)-
2-(2'-Diethylaminoethyl-thio)benzimidazole
Ethanamine, 2-(1H-benzimidazol-2-ylthio)-N,N-diethyl-
CAM2K6Z379
2-(1H-Benzimidazol-2-ylthio)-N,N-diethylethanamine
NSC-44960
Benzimidazole, 2-[[2-(diethylamino)ethyl]thio]-
NSC 44960
BRN 0177537
NSC44960
Ethanamine,N-diethyl-
ChemDiv2_003717
Cambridge id 5686130
UNII-CAM2K6Z379
Oprea1_613748
Oprea1_876500
5-23-11-00279 (Beilstein Handbook Reference)
SCHEMBL9511125
DTXSID40180012
HMS1379I21
[2-(1H-1,3-BENZODIAZOL-2-YLSULFANYL)ETHYL]DIETHYLAMINE
CCG-16593
STK370564
AKOS000639670
IDI1_002432
(2-benzimidazol-2-ylthioethyl)diethylamine
EU-0038172
ST50244940
AB00093499-01