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Albendazole

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Identification
Molecular formula
C12H15N3S
CAS number
54965-21-8
IUPAC name
2-(1H-benzimidazol-2-ylsulfanyl)ethanamine
State
State
Solid at room temperature with an off-white to pale yellow coloration.
Melting point (Celsius)
208.00
Melting point (Kelvin)
481.20
Boiling point (Celsius)
427.10
Boiling point (Kelvin)
700.30
General information
Molecular weight
265.34g/mol
Molar mass
265.3360g/mol
Density
1.3660g/cm3
Appearence

Albendazole appears as an off-white to pale yellow crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 2-(1H-benzimidazol-2-ylsulfanyl)ethanamine

The solubility of 2-(1H-benzimidazol-2-ylsulfanyl)ethanamine can be described through several key characteristics that influence its behavior in various solvents. Understanding these factors is crucial for applications in pharmaceuticals and chemical research. Here are some notable points:

  • Solvent Compatibility: This compound may exhibit varying solubility in polar versus non-polar solvents. Generally, compounds containing functional groups that can engage in hydrogen bonding tend to dissolve better in polar solvents.
  • Temperature Dependence: Solubility often increases with temperature, suggesting that higher temperatures could enhance the dissolution of 2-(1H-benzimidazol-2-ylsulfanyl)ethanamine in suitable solvents.
  • pH Sensitivity: Being an amine, its solubility may be affected by the pH of the solution. In acidic conditions, it might exist in its protonated form, which can increase solubility in water.
  • Concentration Effects: At higher concentrations, solubility could lead to precipitation, indicating that saturation points must be carefully monitored.

As a result, the solubility of 2-(1H-benzimidazol-2-ylsulfanyl)ethanamine is not straightforward and can vary widely based on these conditions. For researchers and chemists, understanding these variables is essential for optimizing solvent selection in experimental setups.

Interesting facts

Interesting Facts about 2-(1H-benzimidazol-2-ylsulfanyl)ethanamine

2-(1H-benzimidazol-2-ylsulfanyl)ethanamine is a fascinating organic compound with significant implications in various fields, particularly in medicinal chemistry. Here are some notable points to consider:

  • Biological Relevance: This compound is associated with active pharmacological properties, making it a subject of interest in drug development. Its ability to interact with biological systems suggests potential therapeutic applications.
  • Structure Activity Relationship (SAR): The presence of the benzimidazole moiety in its structure is crucial, as it relates to the compound's ability to mimic purine and has shown efficacy against several targets within the biological pathways.
  • Role in Research: Chemists are exploring this compound's potential in treating diseases due to its structural features that may enable it to inhibit specific enzymes, offering new hope in targeted therapy.
  • Versatile Synthesis: The synthetic pathways leading to this compound can often involve multiple steps, allowing chemists to optimize and modify its structure for better activity or reduced toxicity.
  • Key Insights: As a part of the broader family of benzimidazole derivatives, it shares characteristics with compounds that have shown antifungal, antibacterial, and anticancer activities.

In summary, 2-(1H-benzimidazol-2-ylsulfanyl)ethanamine showcases the importance of compound structure in determining biological activity. Its unique chemical framework not only expands the arsenal of tools available to researchers but also highlights the intricate relationship between chemistry and medicine.

Synonyms
17124-80-0
2-((1H-benzo[d]imidazol-2-yl)thio)ethanamine
2-(1H-benzimidazol-2-ylsulfanyl)ethanamine
Ethanamine, 2-(1H-benzimidazol-2-ylthio)- (9CI)
Enamine_000329
2-(1H-Benzoimidazol-2-ylsulfanyl)-ethylamine
Oprea1_532245
SCHEMBL6530086
HMS1394O21
AKOS000204454
DB-275718
Ethanamine, 2-(1H-benzimidazol-2-ylthio)-
2-(1 h-benzoimidazol-2-ylsulfanyl)-ethylamine
EN300-242691
2-[(2-aminoethyl)sulfanyl]-1h-1,3-benzodiazole
2-(1H-1,3-benzodiazol-2-ylsulfanyl)ethan-1-amine