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Histamine

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Identification
Molecular formula
C3H9N3
CAS number
51-45-6
IUPAC name
2-(1H-imidazol-5-yl)-2-methyl-propan-1-amine
State
State

At room temperature, histamine is usually encountered as a solid, though it exists in equilibrium with its aqueous form as a solution.

Melting point (Celsius)
83.50
Melting point (Kelvin)
356.65
Boiling point (Celsius)
129.00
Boiling point (Kelvin)
402.15
General information
Molecular weight
111.16g/mol
Molar mass
111.1570g/mol
Density
1.0900g/cm3
Appearence

Histamine typically appears as a colorless hygroscopic crystalline solid at room temperature. It can also be found in a crystalline powder form, without any distinct odor, and can convert to a thixotropic gel when in a moist environment.

Comment on solubility

Solubility of 2-(1H-imidazol-5-yl)-2-methyl-propan-1-amine

The solubility of 2-(1H-imidazol-5-yl)-2-methyl-propan-1-amine is an important aspect to consider for various applications. Here are some key points regarding its solubility:

  • General Solubility: This compound is generally soluble in polar solvents due to its functional groups, particularly the imidazole ring, which enhances its interaction with polar molecules.
  • Water Solubility: It exhibits a moderate degree of solubility in water, allowing it to partake in biochemical processes effectively. Additionally, it may also exist as a protonated form in acidic conditions, increasing its hydration and solubility.
  • Solvent Compatibility: The compound is likely more soluble in alcohols such as ethanol and methanol, and less soluble in nonpolar solvents like hexane.

Overall, factors influencing the solubility of 2-(1H-imidazol-5-yl)-2-methyl-propan-1-amine include:

  1. The presence of polar groups which enhance solubility.
  2. The molecular weight and size, which may impede solubility in certain environments.
  3. Temperature and pH, both of which can significantly shift solubility dynamics.

In summary, understanding the solubility characteristics of this compound can provide insights into its chemical behavior and potential applications in various fields, making it an intriguing subject for further investigation.

Interesting facts

Interesting Facts about 2-(1H-imidazol-5-yl)-2-methyl-propan-1-amine

This fascinating compound, known for its diverse applications in biochemistry and pharmacology, features an imidazole ring that plays a vital role in many biological systems. Here are some noteworthy insights into its significance:

  • Biological Relevance: The imidazole moiety is a key feature in several amino acids such as histidine, which is essential for enzyme activity and metal ion coordination in biological systems.
  • Pharmacological Potential: This compound shows promise as a pharmacophore in drug design, likely due to its ability to interact with various biological targets.
  • Versatility: Its unique structure makes it suitable for use in the synthesis of novel compounds that could exhibit a diverse range of biological activities, potentially leading to new therapeutic agents.
  • Research Applications: It's often employed in studies investigating receptor interactions and enzyme inhibitions, showcasing its utility in medicinal chemistry.
  • Synthetic Pathways: The synthesis of this compound often utilizes straightforward organic reactions, allowing for easy modification, exploration of structure-activity relationships, and broader derivatives synthesis.

As a scientist, one might find it intriguing how the design and modification of simple molecular structures like 2-(1H-imidazol-5-yl)-2-methyl-propan-1-amine can lead to the development of complex pharmaceuticals. With relations to both fundamental physiology and advanced therapeutics, this compound exemplifies the interconnectivity of synthetic chemistry and biological function.

All in all, the study of this compound not only deepens our understanding of imidazole-containing molecules but also opens doors to innovations in drug discovery and development.

Synonyms
21150-01-6
2-(1H-imidazol-5-yl)-2-methylpropan-1-amine
BETA,BETA-DIMETHYL-1H-IMIDAZOLE-4-ETHANAMINE
Imidazole, 4-(2-amino-1,1-dimethylethyl)-
SCHEMBL7179426
CHEMBL3305036
SCHEMBL14415970
.beta.,.beta.-Dimethylhistamine
DTXSID90175392
OKJUBHQJVNBSOG-UHFFFAOYSA-N
WAA15001
AKOS006375408
EN300-1817828
2-(1H-Imidazol-4-yl)-2-methyl-1-propanamine #
1H-Imidazole-4-ethanamine, .beta.,.beta.-dimethyl-