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Histamine

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Identification
Molecular formula
C5H9N3
CAS number
51-45-6
IUPAC name
2-(1H-imidazol-5-yl)-N-methyl-ethanamine
State
State

At room temperature, histamine exists in a solid state. It is highly reactive and soluble in water, which underlines its biological relevance as a biogenic amine in the human body.

Melting point (Celsius)
82.50
Melting point (Kelvin)
355.70
Boiling point (Celsius)
209.50
Boiling point (Kelvin)
482.70
General information
Molecular weight
111.15g/mol
Molar mass
111.1540g/mol
Density
1.0840g/cm3
Appearence

Histamine at room temperature is typically a colorless hygroscopic crystal that can also appear in a white crystalline form.

Comment on solubility

Solubility of 2-(1H-imidazol-5-yl)-N-methyl-ethanamine

The solubility of 2-(1H-imidazol-5-yl)-N-methyl-ethanamine (C5H9N3) exhibits interesting characteristics that are associated with its molecular structure. This compound contains both hydrophilic and hydrophobic regions due to the presence of the imidazole ring and the amine functional group, which typically influences solubility in different solvents.

Key Insights on Solubility:

  • Water Solubility: Due to the ionic nature of the amine group, this compound shows good solubility in polar solvents such as water. It is likely to form hydrogen bonds, enhancing its solubility.
  • Solvent Interactions: The presence of the imidazole moiety may contribute to unique interactions with various solvents, potentially allowing for dissolution in a range of organic solvents as well.
  • pH Dependence: The solubility of this compound can be pH-dependent; it may increase in alkaline conditions where the amine group is protonated, enhancing its interaction with water molecules.
  • Temperature Effects: Like many organic compounds, solubility may increase with temperature. Higher temperatures can disrupt intermolecular interactions, leading to increased dissolution rates.

Overall, while this compound is generally soluble in water, its solubility profile is complex and influenced by multiple factors such as temperature, pH, and solvent choice. Understanding these parameters is vital for practical applications in both laboratory and industrial settings.

Interesting facts

Exploring 2-(1H-imidazol-5-yl)-N-methyl-ethanamine

2-(1H-imidazol-5-yl)-N-methyl-ethanamine, commonly known for its interesting structural attributes, is a fascinating compound within the realm of organic chemistry. Here are some captivating facts about this molecule:

  • Versatile Derivatives: This compound is a derivative of imidazole, a five-membered ring compound that has significant presence in various biological systems, particularly in the structure of amino acids and nucleic acids.
  • Biological Significance: The presence of the imidazole moiety grants it potential biological activity. Compounds featuring imidazole rings are often involved in enzyme catalysis and metabolic processes.
  • Influence on Receptors: Compounds similar to 2-(1H-imidazol-5-yl)-N-methyl-ethanamine may interact with histamine receptors, possibly impacting physiological responses such as inflammation and neurotransmission.
  • Synthetic Pathways: Scientists are fascinated by the methods of synthesizing this compound, which often involves multi-step reactions, showcasing the intricate nature of organic synthesis.
  • Research Opportunities: Owing to its unique structure, this compound is of interest for research in medicinal chemistry, where modifications can lead to the discovery of new drugs.
  • Pharmacophore: The compound could serve as a pharmacophore scaffold in drug development, bridging synthetic chemistry and pharmaceutical applications.

In summary, 2-(1H-imidazol-5-yl)-N-methyl-ethanamine encapsulates an array of chemical properties and potential applications. Its exploration is a significant stride in both academic and practical chemistry, showcasing the seamless integration of structure and function in complex biological systems.

Synonyms
673-50-7
1H-Imidazole-4-ethanamine, N-methyl-
N-alpha-methylhistamine
4-(2-Methylaminoethyl)imidazole
2-(1H-imidazol-5-yl)-N-methylethanamine
Nalpha-Methylhistamine
N'-Methylhistamine
NAMH
N(alpha)-methylhistamine
N.alpha.-Methylhistamine
Imidazole, 4-(2-(methylamino)ethyl)-
Y7QR253130
Imidazole, 4-[2-(methylamino)ethyl]-
[2-(1H-imidazol-5-yl)ethyl](methyl)amine
N(sup alpha)-Methylhistamine
2-(3H-imidazol-4-yl)-N-methylethanamine
[3H]-Na-methylhistamine
[3H]NAMH
N-[3H]alpha-methylhistamine
UNII-Y7QR253130
N-alpha-MeHA
Tocris-0573
SCHEMBL119179
[3H]N-alpha-methyl histamine
CHEMBL268490
GTPL1239
GTPL1240
SCHEMBL2086409
N(sup .alpha.)-Methylhistamine
BDBM22530
DTXSID00217671
CHEBI:184982
PHSPJQZRQAJPPF-UHFFFAOYSA-N
N-Methyl-1h-imidazole-4-ethanamine
PDSP1_000543
PDSP2_000541
AKOS006348059
AKOS015906002
N-alpha-methylhistamine-dihydrochloride
NCGC00024660-01
NCGC00024660-02
NCGC00024660-03
[2-(1H-imidazol-4-yl)ethyl](methyl)amine
DB-055022
4-(2-(N-METHYLAMINO)ETHYL)IMIDAZOLE
4-(2-METHYLAMINOETHYL)-1H-IMIDAZOLE
NS00014791
1H-IMIDAZOLE-5-ETHANAMINE, N-METHYL-
EN300-170734
N-[2-(1H-imidazol-5-yl)ethyl]-N-methylamine
2-(1H-IMIDAZOL-4-YL)-N-METHYLETHANAMINE
L000451
N-[2-(1H-Imidazol-4-yl)ethyl]-N-methylamine #
BRD-K64422603-300-02-7
IMIDAZOLE, 4(OR 5)-(2-(METHYLAMINO)ETHYL)-
Q27078066