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Indole-3-carboxylic acid hydrazide

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Identification
Molecular formula
C10H9N3O
CAS number
2889-69-0
IUPAC name
2-(1H-indol-3-yl)-2-oxo-acetohydrazide
State
State

At room temperature, Indole-3-carboxylic acid hydrazide is typically in a solid state.

Melting point (Celsius)
217.00
Melting point (Kelvin)
490.15
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.15
General information
Molecular weight
189.20g/mol
Molar mass
189.1950g/mol
Density
1.2300g/cm3
Appearence

Indole-3-carboxylic acid hydrazide appears as an off-white to pale yellow crystalline solid. It has a characteristic odor and can form fine crystals under certain conditions.

Comment on solubility

Solubility of 2-(1H-indol-3-yl)-2-oxo-acetohydrazide

The solubility of 2-(1H-indol-3-yl)-2-oxo-acetohydrazide is influenced by several factors, making it an interesting compound to study. Generally, the solubility can be described as follows:

  • Polarity: The presence of various functional groups in the molecule often determines its polarity, affecting its interaction with solvents. In this case, the hydrazide component can contribute to its solubility in polar solvents.
  • Solvent Choice: This compound tends to dissolve well in dimethyl sulfoxide (DMSO) and methanol, while exhibiting limited solubility in nonpolar solvents like hexane or chloroform.
  • Temperature Dependence: Like many organic compounds, its solubility may increase with temperature, which can provide valuable insights during chemical synthesis and application processes.

Moreover, it's essential to consider that pH can also play a significant role in the solubility of 2-(1H-indol-3-yl)-2-oxo-acetohydrazide. In acidic or basic conditions, ionization of functional groups may occur, modifying its solubility profile. Thus, understanding these aspects is crucial for its application in various fields such as pharmaceuticals and biochemistry.

Interesting facts

Interesting Facts about 2-(1H-indol-3-yl)-2-oxo-acetohydrazide

This intriguing compound, 2-(1H-indol-3-yl)-2-oxo-acetohydrazide, is notable for its diverse applications in both medicinal chemistry and material science. Its structure incorporates an indole moiety, which is a key building block in many pharmaceuticals, making it a subject of interest for scientists researching new therapies.

Key Features:

  • Biological Activity: Indole derivatives are known for their biological significance, often exhibiting antimicrobial, antitumor, and anti-inflammatory activities.
  • Research Potential: Given its hydrazide functional group, this compound may also be explored for potential applications in drug development, specifically in the synthesis of novel compounds aimed at targeting various biological pathways.
  • Versatile Synthesis: Researchers have developed various synthetic routes to obtain this compound, providing flexibility in developing derivatives that could enhance its activity or efficacy.

The synthesis of 2-(1H-indol-3-yl)-2-oxo-acetohydrazide typically involves the reaction of indole-based reagents with hydrazine derivatives, allowing for *customization* in the synthesis process.

The indole nucleus is characterized by its unique fused ring system, which contributes substantially to the *biological properties* of compounds derived from it. As stated by chemists, “Exploring the indole scaffold opens up vast possibilities in the realm of medicinal chemistry.”

Conclusion:

The study of this compound not only sheds light on the chemical versatility of indole derivatives but also inspires future research into their practical applications. With its promising biological activity and potential for further derivatization, 2-(1H-indol-3-yl)-2-oxo-acetohydrazide stands out as a noteworthy compound in contemporary chemical research.

Synonyms
INDOLE-3-GLYOXYLIC ACID, HYDRAZIDE
BRN 0186359
1H-Indole-3-acetic acid, alpha-oxo-, hydrazide
5055-37-8
DTXSID10198583
4-22-00-03071 (Beilstein Handbook Reference)
DTXCID70121074
2-(1H-indol-3-yl)-2-oxoacetohydrazide