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Indole-3-acetamide

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Identification
Molecular formula
C10H10N2O
CAS number
879-37-8
IUPAC name
2-(1H-indol-3-yl)acetamide
State
State
Indole-3-acetamide is typically a solid at room temperature. It does not exhibit any notable solubility in water, implying it remains stable as a solid under standard conditions.
Melting point (Celsius)
132.00
Melting point (Kelvin)
405.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
160.20g/mol
Molar mass
160.1790g/mol
Density
1.1809g/cm3
Appearence

Indole-3-acetamide appears as an off-white, crystalline solid. The compound can appear as small granules or powder, and its texture is typically fine. It is notable for its lack of strong color variation, maintaining a fairly uniform appearance.

Comment on solubility

Solubility of 2-(1H-indol-3-yl)acetamide

2-(1H-indol-3-yl)acetamide, with the chemical formula C10H10N2O, exhibits distinct solubility characteristics that are important for its applications in various chemical processes.

In terms of solubility:

  • 2-(1H-indol-3-yl)acetamide is generally soluble in polar solvents such as water and ethanol.
  • Its solubility can be influenced by factors such as temperature and pH, making it crucial to consider these parameters when predicting its behavior in solution.
  • The presence of the amide functional group (-NH2) contributes to its ability to form hydrogen bonds, enhancing its solubility in polar environments.

Furthermore, it is noteworthy that compounds like 2-(1H-indol-3-yl)acetamide may have limited solubility in nonpolar solvents, which aligns with the general trend observed in many amides. As with many organic compounds, understanding the solubility of 2-(1H-indol-3-yl)acetamide is essential for its manipulation in practical applications, such as drug formulation and synthesis.

In conclusion, the solubility profile of 2-(1H-indol-3-yl)acetamide underscores the importance of solvation dynamics in influencing the reactivity and usability of chemical compounds in various domains.

Interesting facts

Exploring 2-(1H-indol-3-yl)acetamide: A Unique Compound

2-(1H-indol-3-yl)acetamide is a fascinating compound that belongs to a larger class of molecules known as indole derivatives. As a scientist, you may find this compound intriguing due to its biochemical properties and potential applications. Here are some interesting facts:

  • Origin: The indole structure, which is the backbone of this compound, is derived from the fusion of a benzene ring and a pyrrole ring. This unique structure contributes significantly to the biological activity of the compound.
  • Biological Significance: Compounds derived from indoles, including 2-(1H-indol-3-yl)acetamide, are known for their role in various biological processes. They have been studied for effects on neurotransmitter activity, showcasing potential in the treatment of mood disorders.
  • Potential Therapeutic Uses: Research has indicated that this compound may exhibit anti-inflammatory and analgesic properties. Its structural similarity to neurotransmitters allows it to interact with the brain's receptors, presenting possibilities for neuropharmacology.
  • Versatile Synthesis: The synthesis of 2-(1H-indol-3-yl)acetamide can be accomplished through various methods, including the condensation of indole with acetyl chloride. This accessibility makes it an interesting target for organic synthesis and medicinal chemistry.

In summary, 2-(1H-indol-3-yl)acetamide is not just another compound; it embodies a rich tapestry of biochemical potential and synthetic versatility. As you delve into the world of indole derivatives, keep in mind that understanding such compounds can lead to major breakthroughs in medicinal chemistry and therapeutic development.

Synonyms
indole-3-acetamide
879-37-8
2-(1H-Indol-3-yl)acetamide
3-Indoleacetamide
1H-Indole-3-acetamide
Indoleacetamide
3-Indolylacetamide
(indol-3-yl)acetamide
MFCD00005641
1H-Indol-3-ylacetamide
2-(3-Indolyl)acetamide
NSC 1969
1-Indole-3-acetamide
Indole-3-acetamide (6CI,8CI)
NSC-1969
EINECS 212-904-4
UNII-O9SEW65XW3
Indole-3-acetamide (8CI)
O9SEW65XW3
CHEBI:16031
ZOAMBXDOGPRZLP-UHFFFAOYSA-
DTXSID60236686
TSR
Auxin amide
3-INDOLE ACETAMIDE
(1H-indol-3-yl)acetamide
1H-indol-3-yl-acetamide
bmse000696
Indole-3-acetamide, 98%
Oprea1_704903
SCHEMBL40822
879-06-1
1H-Indole-3-ethanimidic acid
SCHEMBL8082815
3-Indolylacetamide;NSC 1969
2-(1H-indol-3-yl)-acetamide
DTXCID90159177
NSC1969
2-(1H-Indol-3-yl)acetamide #
HMS1740A02
HMS3604E11
BCP27037
HB0341
s5610
AKOS001129741
CCG-266389
CS-W017500
DB08652
FI30384
FS-2701
HY-W016784
SB15031
AC-23418
SY014237
DB-011565
I0668
NS00039231
EN300-74842
C02693
Q27097844
Z33546521
99FEA035-A073-4863-9F14-923310E3BC45
Indole-3-acetamide; 2-(1H-Indol-3-yl)acetamide; 2-(3-Indolyl)acetamide; 3-Indolylacetamide; NSC 1969