Skip to main content

Streptomycin sulfate

ADVERTISEMENT
Identification
Molecular formula
C21H39N7O12 sulfate
CAS number
3810-74-0
IUPAC name
2-[(1S,2R,3R,4S,5R,6R)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)tetrahydropyran-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyl-tetrahydrofuran-2-yl]oxy-5-guanidino-3,4,6-trihydroxy-cyclohexyl]guanidine;sulfuric acid
State
State

Streptomycin sulfate is in a solid state at room temperature.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
1457.40g/mol
Molar mass
1 457.4000g/mol
Density
1.6170g/cm3
Appearence

Streptomycin sulfate is typically a white or off-white, odorless, crystalline powder. It is hygroscopic and highly soluble in water.

Comment on solubility

Solubility of 2-[(1S,2R,3R,4S,5R,6R)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)tetrahydropyran-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyl-tetrahydrofuran-2-yl]oxy-5-guanidino-3,4,6-trihydroxy-cyclohexyl]guanidine; sulfuric acid

The solubility characteristics of this complex compound can be intriguing due to its structural intricacies and functional groups. Here are some key aspects to consider:

  • Polar Characteristics: Given the presence of multiple hydroxyl groups (–OH) and guanidine moieties, the compound is likely to exhibit high solubility in polar solvents like water. The strong hydrogen bonding capabilities of these groups facilitate interactions with water molecules.
  • Acidic Influence: When combined with sulfuric acid, the solubility may further enhance as the acid can ionize certain groups, leading to the formation of soluble ionic species.
  • Potential Solvent Interaction: Different solvent mediums can affect solubility. The compound may show varying solubility in organic solvents, which would depend on their polarity.
  • Temperature Dependency: Solubility could also be temperature-dependent; typically, higher temperatures may increase the solubility of organic compounds, though this depends on specific chemical interactions.

In conclusion, this compound's solubility is influenced by its complex structure and the interactions present, making it a compound of interest for detailed solubility studies. As with many compounds, predictions about solubility can be enhanced by empirical testing under various conditions.

Interesting facts

Interesting Facts About the Compound

This intriguing compound, commonly known for its elaborate structure, presents a fascinating example of molecular complexity and functionality. Often encountered in biochemical research, this compound can play significant roles, particularly in the context of pharmacology and biochemistry.

Structural Complexity

One of the most striking aspects of this compound is its intricate stereochemistry. This compound features multiple chiral centers, which are critical in determining its biological activity. The correct orientation of these chiral centers is crucial because:

  • Enantiomers: Different enantiomers of a chiral compound can exhibit drastically different biological effects.
  • Interactions: The specific three-dimensional arrangement of atoms can influence how well the compound interacts with biological targets, such as enzymes or receptors.

Biological Applications

This compound has garnered attention in various domains of research, particularly for its potential therapeutic applications:

  • Antidiabetic Agent: Due to its structural resemblance to important biomolecules, this compound may exhibit characteristics akin to antidiabetic properties.
  • Neuroprotective Effects: Ongoing studies are investigating its capability to cross the blood-brain barrier, suggesting possible neuroprotective benefits.
  • As a Research Tool: In studies of metabolic pathways and cellular signaling, this compound may serve as an important probe to elucidate biochemical mechanisms.

Importance of Functional Groups

The presence of multiple functional groups significantly contributes to the versatility of this compound. For instance:

  • Hydroxyl Groups: These polar groups can enhance solubility in biological systems.
  • Guanidine Moiety: Known for its basicity and ability to form hydrogen bonds, this part of the molecule may help in stabilizing interactions with target biomolecules.

In conclusion, this compound epitomizes the complexity and diversity of chemical entities in medicinal chemistry. Its intricate structure not only poses challenges in synthesis but also paves the way for groundbreaking discoveries in therapeutic applications. As scientists delve deeper into the chemical intricacies, the potential benefits this compound may offer continue to unfold.

Synonyms
Dihydrostreptomycin sulfate
5490-27-7
Didromycin
Didromycine
Panstreptin
DIHYDROSTREPTOMYCIN SESQUISULFATE
Dihydrostreptomyzinsulfat
Dihydrostreptomycin 3/2 sulfate
EINECS 226-823-7
UNII-T7D4876IUE
T7D4876IUE
Dihydrostreptomycin sequisulphate
Dihydrostreptomycinium sulfuricum
Dihydrostreptomycin sulfate (2:3)(salt)
DTXSID6045824
AI3-50133
Dihydrostreptomycin Sulfate [USP]
NSC-756739
DTXCID4025824
Dihydrostreptomycin sulfate (USP)
DIHYDROSTREPTOMYCIN SULPHATE (2:3)(SALT)
D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1->2)-O-5-deoxy-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl-(1->4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3)
D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
DIHYDROSTREPTOMYCIN SULFATE (MART.)
DIHYDROSTREPTOMYCIN SULFATE [MART.]
DIHYDROSTREPTOMYCIN SULFATE (USP-RS)
DIHYDROSTREPTOMYCIN SULFATE [USP-RS]
DIHYDROSTREPTOMYCIN SULFATE (USP MONOGRAPH)
DIHYDROSTREPTOMYCIN SULFATE [USP MONOGRAPH]
Pfizer-Strep
Sulfate, Dihydrostreptomycin
226-823-7
D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-, Sulfate(2:3)(salt)
Dihydrostreptomycin sulphate
2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine;sulfuric acid
1,1'-((1R,2R,3S,4R,5R,6S)-4-(((2R,3R,4R,5S)-3-(((2S,3S,4S,5R,6S)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-4-(hydroxymethyl)-5-methyltetrahydrofuran-2-yl)oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl)diguanidine sesquisulfate
NCGC00094655-01
CAS-5490-27-7
CHEMBL3188576
>/=730IU/mg(dried substance)
Dihydrostreptomycin sulfate(2:3)
CZWJCQXZZJHHRH-YCRXJPFRSA-N
C42H88N14O36S3
Tox21_111309
Dihydrostreptomycin sesquisulfate, EP
AKOS026750384
AKOS037515800
AD22045
AD175759
D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
DA-62889
DIHYDROSTREPTOMYCIN SULFATE [WHO-DD]
DIHYDROSTREPTOMYCIN SESQUISULFATE [MI]
NS00076365
D02512
DIHYDROSTREPTOMYCIN SULFATE [GREEN BOOK]
Q27289765
O-2-deoxy-2-(methylamino)-a-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-(hydroxymethyl)-a-L-lyxofuranosyl-(1?4)-N1,N3-bis(aminoiminomethyl) -D-streptamine sulfate;Didromycin;Didromycine