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Fluticasone Propionate

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Identification
Molecular formula
C25H31F3O5S
CAS number
80474-14-2
IUPAC name
[2-[(1S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl] dihydrogen phosphate
State
State

At room temperature, fluticasone propionate is in a solid state. It is often found in the form of a powder.

Melting point (Celsius)
273.00
Melting point (Kelvin)
546.15
Boiling point (Celsius)
541.50
Boiling point (Kelvin)
814.65
General information
Molecular weight
500.57g/mol
Molar mass
500.5740g/mol
Density
1.4900g/cm3
Appearence

Fluticasone propionate is typically a white to off-white powder. It is crystalline in nature and often appears in fine particle forms used for various pharmaceutical preparations.

Comment on solubility

Solubility of 2-[(1S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl dihydrogen phosphate

The solubility of the compound 2-[(1S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl dihydrogen phosphate can be complex and influenced by various factors. Understanding its solubility is crucial for applications in fields ranging from pharmaceuticals to environmental chemistry.

Factors influencing solubility:

  • Polarity: The presence of phosphate groups typically increases polarity, which can enhance solubility in polar solvents, such as water.
  • Molecular structure: The intricate structure with multiple ring systems and functional groups can affect how the compound interacts with solvents.
  • Temperature: As a general trend, increasing temperature can increase solubility for many compounds.

In addition, the solubility of this compound may be characterized by the following observations:

  • Potential for partial solubility: It is likely that the compound will exhibit partial solubility in aqueous solutions due to its complex molecular framework.
  • Dependence on solvent: In non-polar solvents, decreased solubility is expected, highlighting the necessity of choosing appropriate solvents for dissolution.
  • Comparative solubility: Its solubility profile might be compared against similar phosphonate compounds to predict behavior in various environmental conditions.

As a final note, detailed solubility testing, including quantitative analysis, would be invaluable for concrete data, shedding light on how this compound behaves in solutions.

Interesting facts

Interesting Facts about 2-[(1S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl dihydrogen phosphate

This complex compound is a fascinating example of biomolecular design and has intrigued researchers due to its potential applications in various fields like pharmaceuticals and biochemistry. Here are some interesting aspects:

  • Structural Complexity: The compound features a unique architecture with multiple fused rings and functional groups. Its detailed stereochemistry (1S, 4R, etc.) plays a critical role in defining its biological interactions.
  • Fluorine's Role: The inclusion of fluoro groups can significantly enhance the compound's metabolic stability and bioactivity, making it a point of interest in drug design.
  • Biosynthetic Inspiration: The intricate structure is reminiscent of naturally occurring compounds, potentially inspiring synthetic pathways or methods to design similar, biologically active molecules.
  • Phosphate Group: The presence of the dihydrogen phosphate moiety signifies its potential involvement in biological phosphorylation processes, which are essential in cellular signaling and energy transfer.
  • Targeted Research: Scientists are exploring derivatives of such complex compounds for their therapeutic potential, including anti-cancer agents and treatments for other diseases, given their multi-functional nature.

In conclusion, 2-[(1S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl dihydrogen phosphate embodies the synergy of complexity and functionality, making it a subject ripe for exploration in modern chemistry. The ongoing studies are likely to unravel more of its mysteries, underscoring the compound's significance in advancing medicinal chemistry.