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Dactinomycin

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Identification
Molecular formula
C62H86ClN13O16
CAS number
50-76-0
IUPAC name
2-[[2-[[1-[14-chloro-3-ethyl-11,15-dihydroxy-7-isopropenyl-3-methyl-10-(methylamino)-6,9-dioxo-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(15),12(16),13-triene-4-carbonyl]-2,5-dihydropyrrole-2-carbonyl]amino]-3-methyl-pent-2-enoyl]amino]but-2-enedioic acid
State
State

At room temperature, dactinomycin is a solid. It is typically handled in dry, sterile conditions to maintain its stability and efficacy as it is used often in clinical settings.

Melting point (Celsius)
0.00
Melting point (Kelvin)
273.15
Boiling point (Celsius)
316.40
Boiling point (Kelvin)
589.55
General information
Molecular weight
1255.43g/mol
Molar mass
1 255.4340g/mol
Density
1.2810g/cm3
Appearence

Dactinomycin, also known as actinomycin D, typically appears as an orange-red crystalline powder. The compound is relatively stable under normal temperature and pressure when stored appropriately.

Comment on solubility

Solubility of 2-[[2-[[1-[14-chloro-3-ethyl-11,15-dihydroxy-7-isopropenyl-3-methyl-10-(methylamino)-6,9-dioxo-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(15),12(16),13-triene-4-carbonyl]-2,5-dihydropyrrole-2-carbonyl]amino]-3-methyl-pent-2-enoyl]amino]but-2-enedioic acid

The solubility of complex organic compounds such as 2-[[2-[[1-[14-chloro-3-ethyl-11,15-dihydroxy-7-isopropenyl-3-methyl-10-(methylamino)-6,9-dioxo-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(15),12(16),13-triene-4-carbonyl]-2,5-dihydropyrrole-2-carbonyl]amino]-3-methyl-pent-2-enoyl]amino]but-2-enedioic acid (C62H86ClN13O16) is influenced by several factors:

  • Molecular Structure: The intricate structure contributes to the overall stability of the compound, potentially leading to reduced solubility in common solvents.
  • Polar and Non-Polar Groups: The presence of both polar (hydroxyl and amine) and non-polar (alkyl chains) functional groups can create challenges in solubility, often requiring specific solvents to achieve dissolution.
  • Hydrogen Bonding: The ability of the compound to participate in hydrogen bonding can enhance solubility in polar solvents, especially water.
  • pH Dependence: The solubility may vary considerably with changes in pH, particularly due to the acidic moieties present in the structure.

In summary, while definitive solubility data might not be readily available, it is essential to consider these factors when predicting how this compound behaves in various solvents. Understanding the intricate balance between polar and non-polar interactions, along with other structural considerations, plays a critical role in assessing solubility in scientific applications.

Interesting facts

Interesting Facts about 2-[[2-[[1-[14-chloro-3-ethyl-11,15-dihydroxy-7-isopropenyl-3-methyl-10-(methylamino)-6,9-dioxo-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(15),12(16),13-triene-4-carbonyl]-2,5-dihydropyrrole-2-carbonyl]amino]-3-methyl-pent-2-enoyl]amino]but-2-enedioic acid

This compound, with its intricate structure and unique components, is a fascinating subject of study in the field of chemical sciences. Here are some essential facts that demonstrate its complexity and potential applications:

  • Structural Complexity: The compound features multiple functional groups, including amines and carboxylic acids, which contribute to its diverse reactivity and potential interactions.
  • Biological Significance: With its unique bicyclic structure, this compound may hold promise in medicinal chemistry, especially in the synthesis of pharmaceuticals.
  • Mechanistic Insights: The presence of chlorinated and methylated groups may infer unique *electronic properties* that can be exploited for catalytic processes.
  • Multi-Step Synthesis: The synthesis of such complex compounds frequently requires a series of carefully controlled reactions, highlighting the importance of precision in organic synthesis.
  • Research Potential: Given its unique structure, this compound is a candidate for further study in drug formulation and development due to its potential therapeutic effects.

The sheer size and diversity of this compound invite further exploration. As famed chemist Linus Pauling once said, "The best way to have a good idea is to have a lot of ideas." This highlights the importance of creativity and multifaceted approaches in studying such complex compounds.

In summary, the study of this compound is a testament to both the challenges and opportunities that arise in the field of synthetic chemistry. Its multifaceted structure not only poses intriguing questions for researchers but also paves the way for groundbreaking discoveries.

Synonyms
Phomopsin A