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Leupeptin

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Identification
Molecular formula
C20H38N6O4
CAS number
103476-89-7
IUPAC name
2-[[2-[[1-[2-[[2-[[2-[[1-[1-(2-amino-5-guanidino-pentanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenyl-propanoyl]amino]-5-guanidino-pentanoic acid
State
State
It is a solid at room temperature.
Melting point (Celsius)
223.50
Melting point (Kelvin)
496.60
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
475.59g/mol
Molar mass
475.5870g/mol
Density
1.4000g/cm3
Appearence
Appears as a white crystalline powder.
Comment on solubility

Solubility of 2-[[2-[[1-[2-[[2-[[2-[[1-[1-(2-amino-5-guanidino-pentanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenyl-propanoyl]amino]-5-guanidino-pentanoic acid

The solubility of 2-[[2-[[1-[2-[[2-[[2-[[1-[1-(2-amino-5-guanidino-pentanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenyl-propanoyl]amino]-5-guanidino-pentanoic acid (C20H38N6O4) is a complex phenomenon influenced by several factors:

  • Polarity: The structure contains multiple polar functional groups that enhance its interaction with polar solvents, making it more soluble in water compared to nonpolar solvents.
  • Hydrogen Bonding: The presence of amine and carbonyl groups facilitates extensive hydrogen bonding with water molecules, further promoting solubility.
  • pH Sensitivity: As an amino acid derivative, its solubility may vary significantly with changes in pH. In acidic conditions, it may exist in a protonated form, enhancing solubility.
  • Temperature Dependency: Generally, solubility increases with temperature for many compounds, and this compound may also show similar behavior.

In conclusion, while the solubility of this compound is enhanced by its hydrophilic characteristics, further empirical studies are required to quantitatively determine its solubility in various solvents under different conditions. As stated in the scientific community, "the solubility of compounds is a key factor in their biological activity and pharmaceutical applications."

Interesting facts

Interesting Facts about 2-[[2-[[1-[2-[[2-[[2-[[1-[1-(2-amino-5-guanidino-pentanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenyl-propanoyl]amino]-5-guanidino-pentanoic acid

This remarkable compound is a representative of a class of molecules known as peptide derivatives, which hold significant potential in medicinal chemistry and drug development. Here are a few thought-provoking facts about this compound:

  • Complex Structure: The intricate design of this molecule demonstrates a sophisticated arrangement of amino acids and functional groups, which play crucial roles in its biological activity.
  • Biological Relevance: Compounds like this one are often explored for their therapeutic applications, particularly in the field of proteomics and peptidomimetics. Targeting specific biological pathways can lead to innovative drugs for diseases.
  • Synthesis Challenges: The synthesis of such complex molecules presents substantial challenges to chemists, as it often involves multiple steps with careful control over reaction conditions to prevent undesired side reactions.
  • Interdisciplinary Connections: This compound lies at the intersection of chemistry and biology, linking synthetic organic chemistry with pharmaceutical applications, showcasing the importance of cross-disciplinary research.
  • Potential Applications: While currently a subject of study, there is potential for this compound to influence the development of antibiotics, antivirals, and even cancer therapeutics.

Overall, molecules like this demonstrate the endless possibilities within the realm of chemical research. As scientists delve deeper into their characteristics, the implications for future drug design and health applications continue to expand, paving the way for new frontiers in medicine.

Synonyms
SCHEMBL7949679
PBK-4002-V
BCP27071
Bradykinin (Human, Bovine, Rat, Mouse)
Kallidin I;L-Bradykinin;Synthetic bradykinin
L024084
2-(2-{[1-(2-{2-[2-({1-[1-(2-amino-5-carbamimidamidopentanoyl)pyrrolidine-2-carbonyl]pyrrolidin-2-yl}formamido)acetamido]-3-phenylpropanamido}-3-hydroxypropanoyl)pyrrolidin-2-yl]formamido}-3-phenylpropanamido)-5-carbamimidamidopentanoic acid