Interesting facts
Exploring 2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetyl]oxyacetic acid
2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetyl]oxyacetic acid is a fascinating compound that exemplifies the complex synergy between chemistry and pharmacology. Its intricate structure includes multiple functional groups, which contribute to its potential biological activities. Here are some interesting aspects of this compound:
- Pharmaceutical Relevance: Compounds with indole and acetoxy groups, such as this one, are often explored for their pharmacological properties, including anti-cancer and anti-inflammatory effects.
- Chlorine's Role: The presence of the 4-chlorobenzoyl moiety may enhance biological activity or alter the lipophilicity of the compound, making it more favorable for membrane penetration and interaction with biological targets.
- Structure-Activity Relationship (SAR): The detailed study of this compound can provide insights into how modifications on its indole structure affect biological efficacy, guiding future drug design.
- Synthetic Pathways: Exploring synthetic routes to obtain this compound showcases the ingenuity required in organic synthesis, often involving multiple steps and protective group strategies.
As with many compounds of similar complexity, studying 2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetyl]oxyacetic acid not only broadens the understanding of chemical interactions but also fuels the ongoing quest for novel therapeutic agents. Its multifaceted nature invites both chemists and biologists alike to unravel its mysteries.
Synonyms
acemetacin
53164-05-9
Rantudil
Emflex
Acemix
Acemetacina
Acemetacine
Acemetacinum
Aximeixin
Rheumibis
Bay f 4975
TVX 1322
indomethacin carboxymethyl ester
Acemetacine [INN-French]
Acemetacinum [INN-Latin]
Acemetacina [INN-Spanish]
TVX 3322
Solart
indometacin glycolic ester
indomethacin glycolic ester
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester
K 708
K-708
EINECS 258-403-4
Rantudil (TN)
Acemetacin [INN:BAN:JAN]
indometacin carboxymethyl ester
NSC-757413
BRN 0501672
DTXSID7022540
CHEBI:31162
5V141XK28X
ACEMETACIN [MI]
ACEMETACIN [INN]
ACEMETACIN [JAN]
MFCD00151473
ACEMETACIN [MART.]
ACEMETACIN [WHO-DD]
2-[2-[1-(4-chloro-2,3,5,6-tetradeuteriobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
CHEMBL189171
DTXCID402540
ACEMETACIN [EP MONOGRAPH]
((1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
5-22-05-00241 (Beilstein Handbook Reference)
(1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure [German]
2-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetoxy)acetic acid
2-(2-(1-(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetoxy)acetic acid
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester
1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid ester with glycolic acid
NSC 757413
TV-1322
NCGC00016868-09
Rantodil
(1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy)essigsaeure
CAS-53164-05-9
Acemetacine (INN-French)
Acemetacinum (INN-Latin)
1-[p-Chlorobenzoyl]-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
Acemetacina (INN-Spanish)
ACEMETACIN (MART.)
ACEMETACIN (EP MONOGRAPH)
Acemetadoc
Acephlogont
Espledol
Azeat
Oldan
Acemetacin Stada
acemetacin von ct
Acemetacin Heumann
{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}acetic acid
1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic Acid Carboxymethyl Ester
2-({2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)acetic acid
Acemetacin intermuti
SMR000058409
SR-01000000070
UNII-5V141XK28X
(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetoxy)acetic acid
1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
2-((2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyl)oxy)acetic acid
2-(2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyloxy)acetic acid
2-{2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyloxy}acetic acid
Prestwick_669
Acemetacin (Emflex)
Acemetacin (Standard)
Spectrum_000428
Prestwick0_000296
Prestwick1_000296
Prestwick2_000296
Prestwick3_000296
Spectrum2_001162
Spectrum3_001868
Spectrum4_000803
Spectrum5_001385
Acemetacin (JP17/INN)
2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
Bay-f-4975
SCHEMBL23843
BSPBio_000232
BSPBio_003316
KBioGR_001285
KBioSS_000908
MLS000028440
MLS006010622
DivK1c_000490
SPECTRUM1500666
Acematacin (anti-inflammatory)
SPBio_001143
SPBio_002451
Acemetacin, analytical standard
BPBio1_000256
HMS501I12
HY-B0482R
KBio1_000490
KBio2_000908
KBio2_003476
KBio2_006044
KBio3_002818
M01AB11
NINDS_000490
HMS1568L14
HMS1921A08
HMS2090E21
HMS2095L14
HMS2230G08
HMS3372K20
HMS3656E22
HMS3712L14
HMS3884P10
Pharmakon1600-01500666
BCP13127
HY-B0482
TVX-1322
WXB15116
Tox21_113473
BDBM50336272
CCG-39550
NSC757413
s2602
AKOS015895194
Tox21_113473_1
AB03974
DB13783
FA16912
IDI1_000490
NCGC00016868-01
NCGC00016868-02
NCGC00016868-03
NCGC00016868-04
NCGC00016868-05
NCGC00016868-06
NCGC00016868-07
NCGC00016868-08
NCGC00016868-11
NCGC00016868-12
NCGC00022084-03
NCGC00022084-04
NCGC00022084-05
NCGC00022084-06
NCGC00022084-07
BS-16970
SBI-0051585.P002
DB-052263
A2452
AB00052149
NS00000533
SW196824-3
D01582
D88520
AB00052149-15
AB00052149_16
AB00052149_17
from D:/data/P.Sapui/gsas_26052012/ps1.cif
EN300-24431224
Q2723146
SR-01000000070-2
SR-01000000070-3
BRD-K67563174-001-05-1
BRD-K67563174-001-09-3
BRD-K67563174-001-16-8
BRD-K67563174-001-17-6
Acemetacin, European Pharmacopoeia (EP) Reference Standard
[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetoxyacetic Acid
[1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetoxy]-acetic acid
[({1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetyl)oxy]acetic acid
[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid carboxymethyl ester
[({1-[(4-chlorophenyl)carbonyl]-2-methyl-5-(methyloxy)-1H-indol-3-yl}acetyl)oxy]acetic acid
[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetoxyacetic Acid[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetoxyacetic Acid
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester;TV-1322;Acemix
258-403-4
Solubility Characteristics of 2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetyl]oxyacetic acid
The solubility of 2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetyl]oxyacetic acid (C21H18ClNO6) is a notable consideration in its applications and functionality. This compound exhibits unique solubility properties that can be attributed to its structural features:
In general, one might find that:
As such, understanding the solubility profile of this compound is essential for predicting its behavior in various chemical environments and applications. Scientists often explore this aspect to facilitate its formulation and usage in pharmaceuticals and other related fields.