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Amantadine

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Identification
Molecular formula
C12H21NO
CAS number
768-94-5
IUPAC name
2-[2-(1-adamantyl)ethylamino]ethanol
State
State

At room temperature, Amantadine is a solid compound, existing in the form of crystalline powder. It maintains stability in this form under standard conditions.

Melting point (Celsius)
182.50
Melting point (Kelvin)
455.65
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
179.30g/mol
Molar mass
179.3020g/mol
Density
1.0600g/cm3
Appearence

Amantadine is typically found as a white to nearly white crystalline powder. It is water-soluble and has a specific and distinct crystalline structure.

Comment on solubility

Solubility of 2-[2-(1-adamantyl)ethylamino]ethanol

2-[2-(1-adamantyl)ethylamino]ethanol, with the formula C13H21N1O1, exhibits interesting solubility characteristics due to its unique structural features. This compound is primarily known for its hydrophobic adamantyl group, which plays a crucial role in its solubility profile.

Key Points on Solubility:

  • Alcohol Solubility: Alcohols generally possess some degree of solubility in water due to their hydroxyl (-OH) groups. This compound's secondary amine and hydroxyl provide the potential for hydrogen bonding with water.
  • Hydrophobic Effects: The presence of the bulky adamantyl moiety tends to increase hydrophobicity, which may hinder complete solubility in aqueous environments.
  • Solvent Compatibility: It is likely to exhibit greater solubility in organic solvents such as ethanol, methanol, and DMSO, favoring non-polar solvents due to its hydrophobic characteristics.

In essence, while 2-[2-(1-adamantyl)ethylamino]ethanol can dissolve somewhat in polar solvents due to its functional groups, its overall solubility is compromised by the hydrophobic nature of the adamantyl group. As a result, one might observe the following:

  • The compound may dissolve in water at limited concentrations, particularly upon increasing temperature or agitation.
  • For practical applications, assessing its behavior in mixed solvents might yield the best results for achieving desired concentrations.

Therefore, understanding the balance between hydrophilicity and hydrophobicity in this compound is crucial for its practical application and formulation in various chemical processes.

Interesting facts

Interesting Facts about 2-[2-(1-adamantyl)ethylamino]ethanol

2-[2-(1-adamantyl)ethylamino]ethanol is a fascinating chemical compound distinguished by its unique structure and potential applications. This compound, which features an adamantyl group, is part of a larger family known for their intriguing properties:

  • Adamantyl Group: The adamantyl group is known for its stability and is often utilized in medicinal chemistry due to its ability to improve the pharmacological properties of various drugs.
  • Amine Functionality: As an amine, 2-[2-(1-adamantyl)ethylamino]ethanol can act as a proton acceptor, making it useful in a variety of chemical reactions, including synthesis processes and potentially in drug development.
  • Potential Applications: The compound may have implications in studying nervous system interactions, given the central role of ethanolamines in neurotransmitter systems.
  • Versatility: Its unique structure provides a scaffold for the design of novel compounds that might exhibit interesting biological activities or build new materials.

Researchers in the field continually explore compounds like 2-[2-(1-adamantyl)ethylamino]ethanol for their potential to unlock new pathways in drug discovery and materials science, illustrating the importance of structural features in determining chemical behavior and application.

In the words of a prominent chemist, “The beauty of chemistry lies in its ability to transform simple structures into complex, life-altering solutions.” This saying resonates profoundly with compounds such as 2-[2-(1-adamantyl)ethylamino]ethanol, symbolizing endless possibilities!

Synonyms
SCHEMBL6897880
AKOS004122766