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Cetirizine

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Identification
Molecular formula
C21H25N3O3S
CAS number
83881-52-1
IUPAC name
2-[2-(1-piperidyl)ethoxy]ethyl pyrido[3,2-b][1,4]benzothiazine-10-carboxylate
State
State

At room temperature, Cetirizine typically exists as a solid. It is commonly found in pharmaceuticals in tablet form or as a powder for creating syrups and solutions.

Melting point (Celsius)
109.50
Melting point (Kelvin)
382.65
Boiling point (Celsius)
631.20
Boiling point (Kelvin)
904.35
General information
Molecular weight
461.02g/mol
Molar mass
461.0160g/mol
Density
0.3456g/cm3
Appearence

Cetirizine is a white, crystalline powder. It is generally marketed in the form of tablets or as a syrup. It can also be found in chewable tablet form or completely dissolved in a solution for ease of administration.

Comment on solubility

Solubility of 2-[2-(1-piperidyl)ethoxy]ethyl pyrido[3,2-b][1,4]benzothiazine-10-carboxylate

The solubility of 2-[2-(1-piperidyl)ethoxy]ethyl pyrido[3,2-b][1,4]benzothiazine-10-carboxylate can be intriguing due to its intricate structure. Chemical solubility is influenced by several factors, which can be summarized as follows:

  • Polarity: The presence of ether and carboxylate functional groups suggests potential polar characteristics, which may enhance solubility in polar solvents such as water.
  • Hydrogen Bonding: The nitrogen atoms in the piperidine ring and carboxylate group may engage in hydrogen bonding, which could facilitate solubility in polar environments.
  • Solvent Interaction: This compound may exhibit different solubility behaviors in various organic solvents, such as ethanol or dimethyl sulfoxide (DMSO), depending on the solvent's ability to interact with its functional groups.

It is notable that compounds with extensive ring systems, like 2-[2-(1-piperidyl)ethoxy]ethyl pyrido[3,2-b][1,4]benzothiazine-10-carboxylate, can often demonstrate limited solubility due to steric hindrance and solid-state packing effects. However, its synthetic applications and biological activity can provide avenues for improving solubility through structural optimization.

Therefore, while _"solubility"_ is a complex and multi-dimensional property, the critical factors outlined may provide a useful framework for exploring the solubility behavior of this compound in various environments.

Interesting facts

Interesting Facts about 2-[2-(1-Piperidyl)ethoxy]ethyl Pyrido[3,2-b][1,4]benzothiazine-10-carboxylate

This compound, with its complex name and structure, is a fascinating example of the intersection between medicinal chemistry and organic synthesis. Here are some engaging points to consider:

  • Pharmacological Potential: Compounds like this one often possess unique pharmacological properties, making them candidates for drug development, particularly in treating various neurological and psychiatric disorders.
  • Piperidine Role: The inclusion of the piperidyl group in its structure is noteworthy. Piperidine is a common moiety in many pharmaceuticals, contributing to their efficacy and biological activity.
  • Multi-functional Nature: The combination of the pyrido and benzothiazine structures suggests potential multi-target interactions. This can enhance biological activity within the human body, making this compound a subject of interest for researchers.
  • Ongoing Research: Current studies often investigate its mechanism of action, cellular uptake, and overall metabolic pathways. Understanding these facets can help optimize therapeutic efficacy and reduce side effects.
  • Complex Synthesis: The synthetic route to create this compound is likely intricate, involving several specific reactions that chemists meticulously develop. Such complexity underscores its potential as a valuable tool for exploring chemical interactions within biological systems.

As a chemical scientist or student, exploring 2-[2-(1-Piperidyl)ethoxy]ethyl Pyrido[3,2-b][1,4]benzothiazine-10-carboxylate opens avenues not just in medicinal chemistry but also in understanding the nuanced relationships between chemical structure and biological function. Its growing significance in research is a testament to the ever-evolving landscape of pharmaceutical development.

Synonyms
Pipazethate
Pipazetate
Theratuss
Lenopect
Pipazetate [INN]
Pipazethate [USAN]
Pipazetatum [INN-Latin]
Pipazetato [INN-Spanish]
SQ 15,874
D-254
M5EK1T5V2L
SK&F 70230-A
Pipazetate (INN)
Pipazethate (USAN)
SQ 15874
D 254
PIPAZETHATE [MI]
SKF 70230 A
EINECS 218-508-8
UNII-M5EK1T5V2L
PIPAZETATE [MART.]
BRN 1091957
PIPAZETATE [WHO-DD]
SQ-15874
DTXSID40176056
SKF 70230-A
SK&F-70230-A
10H-Pyrido(3,2-b)(1,4)benzothiazine-10-carboxylic acid, 2-(2-(1-piperidinyl)ethoxy)ethyl ester
SO 15,874
Pipazetatum (INN-Latin)
Pipazetato (INN-Spanish)
PIPAZETATE (MART.)
10H-Pyrido(3,2-b)(1,4)benzothiazine-10-carboxylic acid, 2-(2-piperidinoethoxy)ethyl ester
2-(2-Piperidinoethoxy)ethyl 10H-pyrido(3,2-b)(1,4)benzothiazine-10-carboxylate
2-(2-Piperidinoethoxy)ethyl 10H-pyrido[3,2-b][1,4]benzothiazine-10-carboxylate
10H-Pyrido[3,2-b][1,4]benzothiazine-10-carboxylic acid, 2-(2-piperidinoethoxy)ethyl ester
2-(2-Piperidinoethoxy)ethyl 10H-pyrido[3,2-b][1,4]benzothiadiazine-10-carboxylate
10H-Pyrido[3,2-b][1,4]benzothiazine-10-carboxylic acid, 2-[2-(1-piperidinyl)ethoxy]ethyl ester
2-[2-(piperidin-1-yl)ethoxy]ethyl 9-thia-2,4-diazatricyclo[8.4.0.0^{3,8}]tetradeca-1(10),3,5,7,11,13-hexaene-2-carboxylate
2-(2-Piperidinoethoxy)ethyl 10H-pyrido(3,2-b)(1,4)benzothiadiazine-10-carboxylate
2-(2-(piperidin-1-yl)ethoxy)ethyl 9-thia-2,4-diazatricyclo(8.4.0.0^(3,8))tetradeca-1(10),3,5,7,11,13-hexaene-2-carboxylate
DTXCID1098547
R05DB11
10H-pyrido(3,2-b)(1,4)-benzothiadiazine-10-carboxylic acid 2-(2-piperidinoethoxy)ethyl ester D 254
dtvjxcomjllmak-uhfffaoysa-n
2167-85-3
Pipazetato
2-(2-piperidin-1-ylethoxy)ethyl pyrido[3,2-b][1,4]benzothiazine-10-carboxylate
SKF 70230A; SQ 15874;D 254;Pipazetate
Pipazetatum
Pipazetat
SCHEMBL149990
CHEMBL2104900
CHEBI:135635
CAA16785
HY-B2090
AKOS040753563
DB08796
DA-76907
CS-0017506
NS00001860
D05484
Q7197205
2-[2-(1-Piperidinyl)ethoxy]ethyl 10H-pyrido[3,2-b][1,4]benzothiazine-10-carboxylate #