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Chlorpromazine

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Identification
Molecular formula
C17H19ClN2OS
CAS number
50-53-3
IUPAC name
2-[2-(2-chlorophenothiazin-10-yl)ethoxy]-N,N-dimethyl-ethanamine
State
State

At room temperature, chlorpromazine is most commonly found in solid form when it is pure. It is usually processed and available in the market as tablets or capsules, which are solid, or solutions for injection, which are liquid. As a chemical entity in its pure isolated state, it is a solid.

Melting point (Celsius)
190.50
Melting point (Kelvin)
463.65
Boiling point (Celsius)
572.80
Boiling point (Kelvin)
845.95
General information
Molecular weight
318.86g/mol
Molar mass
318.8640g/mol
Density
1.2580g/cm3
Appearence

Chlorpromazine is typically found as a white or pale yellow crystalline powder in its pure form. When exposed to air, it may oxidize and change in color, taking on a slightly yellowish tint. It is often formulated into tablets, liquids, or injectables for medical use, and in these forms, it may appear as colored tablets or clear solutions depending on the formulation.

Comment on solubility

Solubility of 2-[2-(2-chlorophenothiazin-10-yl)ethoxy]-N,N-dimethyl-ethanamine

The solubility of 2-[2-(2-chlorophenothiazin-10-yl)ethoxy]-N,N-dimethyl-ethanamine can be characterized by various factors that influence its behavior in different solvents. This compound is known for its complex structure, which can significantly affect its solubility profile:

  • Polar solvents: Given the presence of ether and amine functional groups, this compound exhibits varying degrees of solubility in polar solvents like water. However, the overall solubility may be limited due to the hydrophobic phenothiazine moiety.
  • Non-polar solvents: The compound is likely to show higher solubility in non-polar organic solvents such as chloroform or toluene due to the non-polar characteristics of the chlorophenothiazine ring.
  • Temperature dependence: Solubility can also be temperature-dependent; typically, as temperature increases, the solubility of solid compounds in liquids increases.

In summary, while 2-[2-(2-chlorophenothiazin-10-yl)ethoxy]-N,N-dimethyl-ethanamine has the potential to solubilize in various environments, it is highly influenced by its structural components and the polarity of the solvent. Understanding these interactions is crucial for applications in pharmaceutical formulations and chemical processes.

Interesting facts

Interesting Facts about 2-[2-(2-chlorophenothiazin-10-yl)ethoxy]-N,N-dimethyl-ethanamine

This compound belongs to a class of chemicals known as phenothiazines, which are primarily recognized for their role in medicinal chemistry. Often used as antipsychotic agents, phenothiazines have a fascinating history in the treatment of mental health disorders.

Here are some key highlights about this compound:

  • Medicinal Use: This compound is a derivative of phenothiazine, suggesting potential applications in psychopharmacology, specifically in treating schizophrenia and other mental health issues.
  • Structure and Function: The presence of the 2-chlorophenothiazin component may contribute to its biological activity, particularly in neurotransmitter receptor binding.
  • Ethoxy Group Role: The ethoxy group in its structure is crucial as it often enhances lipophilicity, improving the ability of the molecule to cross the blood-brain barrier.
  • Dimethylamine Element: The N,N-dimethyl-ethanamine part adds to the molecule's stability and can modify the pharmacokinetic properties, influencing absorption and distribution in the body.
  • Research Interest: Scientists continue to explore the array of phenothiazine derivatives for their diverse pharmacological profiles. This compound may also be investigated for its potential anti-inflammatory or analgesic properties.

In conclusion, 2-[2-(2-chlorophenothiazin-10-yl)ethoxy]-N,N-dimethyl-ethanamine exemplifies the complexity of drug design and the continuous efforts to develop effective therapies for mental health. As the field of medicinal chemistry evolves, compounds like this play a pivotal role in advancing medical science.

Synonyms
0TEA5J5O64
2-Chloro-10-(dimethylaminoethoxyethyl)phenothiazine
UNII-0TEA5J5O64
17124-61-7
Phenothiazine, 2-chloro-10-(2-(2-dimethylaminoethoxy)ethyl)-
Ethanamine, 2-(2-(2-chloro-10H-phenothiazin-10-yl)ethoxy)-N,N-dimethyl-
DTXSID60274907
2-[2-(2-chlorophenothiazin-10-yl)ethoxy]-N,N-dimethylethanamine