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Varenicline chloride

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Identification
Molecular formula
C13H13ClFNO
C2H7N
CAS number
375815-87-5
IUPAC name
[2-[2-(2-fluorobenzoyl)pyrrol-1-yl]-1-methyl-ethyl]-dimethyl-ammonium;chloride
State
State

At room temperature, varenicline chloride is typically a solid. In its pharmaceutically prepared forms, it appears in tablets designed for oral administration. It is stable under normal conditions and properly stored in containers that prevent exposure to excessive moisture and light.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
273.00
Boiling point (Kelvin)
546.15
General information
Molecular weight
361.83g/mol
Molar mass
361.8340g/mol
Density
1.1326g/cm3
Appearence

Varenicline chloride commonly appears as a white to off-white crystalline powder when isolated in its pure form. It is generally used in the formulation of pharmaceutical medications, where it can be processed into tablets or capsules depending on its intended use.

Comment on solubility

Solubility of [2-[2-(2-fluorobenzoyl)pyrrol-1-yl]-1-methyl-ethyl]-dimethyl-ammonium;chloride

The solubility of the compound [2-[2-(2-fluorobenzoyl)pyrrol-1-yl]-1-methyl-ethyl]-dimethyl-ammonium;chloride is influenced by its ionic and molecular characteristics. Being a quaternary ammonium compound, it tends to exhibit good solubility in polar solvents, particularly water. The chloride ion in this compound contributes to its ionic nature, which typically enhances solubility in aqueous solutions.

Key factors affecting its solubility include:

  • Ionic Nature: The presence of the chloride ion, which strongly interacts with water molecules, facilitating hydration.
  • Polarity: The overall structure, which incorporates both aromatic and heterocyclic components, influences its interaction with various solvents.
  • Temperature: As with many chemical compounds, solubility may increase with temperature due to enhanced molecular movement and interaction.

In practical applications, it is essential to note that the compound may not be soluble in non-polar solvents, which can limit its use in specific formulations. Understanding these solubility characteristics is crucial for its effective utilization in chemical and pharmaceutical processes.

In conclusion, the solubility of this compound can be summed up as good in polar solvents, with its ionic character being a significant contributing factor. For practical usage, one might consider conducting solubility tests under varying conditions to determine optimal solvent systems.

Interesting facts

Interesting Facts about 2-[2-(2-Fluorobenzoyl)pyrrol-1-yl]-1-methyl-ethyl]-dimethyl-ammonium; chloride

This fascinating compound, commonly referred to as a quaternary ammonium salt, is notable not only for its unique structural components but also for its potential applications in various fields. Here are some intriguing points to consider:

  • Quaternary Structure: The compound features a quaternary ammonium ion, which is characterized by a positively charged nitrogen atom bonded to four organic groups. This structure plays a crucial role in its solubility and reactivity.
  • Fluorinated Aromatics: The presence of a fluorobenzoyl moiety contributes to the compound's stability and enhances its lipophilicity, making it a potential candidate for drug design.
  • Pyrrole Ring: The inclusion of the pyrrol-1-yl group adds to the compound's structural complexity and could influence its biological activity. Pyrrole derivatives are often known for their diverse pharmacological activities.
  • Potential Applications: Compounds like this one are of interest in medicinal chemistry, particularly for their potential use as pharmaceutical agents or in chemical research.
  • Research Interest: The unique properties of such compounds often attract the attention of researchers focused on developing new therapeutic agents, particularly in the fields of oncology and infectious diseases.

As noted by researchers in the field, compounds with intricate structures like this one provide a rich ground for exploration. The synthesis and characterization of these compounds can unveil essential insights into their reactivity and potential therapeutic profiles. As you dive deeper into the structure and its implications, you may find ongoing studies revealing even more about the unique capabilities of this compound!

Synonyms
1-(2-(Dimethylamino)propyl)-2-(o-fluorobenzoyl)pyrrole monohydrochloride
14415-70-4
KETONE, 1-(2-(DIMETHYLAMINO)PROPYL)PYRROL-2-YL o-FLUOROPHENYL, HYDROCHLORIDE