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Benzydamine Hydrochloride

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Identification
Molecular formula
C19H23ClN2O
CAS number
132-69-4
IUPAC name
2-[2-(2,2-diphenyl-1,3-dioxolan-4-yl)piperidin-1-ium-4-yl]-N,N-diethyl-ethanamine;chloride
State
State

At room temperature, Benzydamine Hydrochloride is in the solid state. It is processed in the form of a powder which is compressed into tablets or mixed into other forms for pharmaceutical use.

Melting point (Celsius)
161.00
Melting point (Kelvin)
434.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
489.08g/mol
Molar mass
489.0770g/mol
Density
1.1400g/cm3
Appearence

Benzydamine Hydrochloride typically appears as a white or almost white crystalline powder. It is often odorless or may have a slight characteristic odor. The compound is generally manufactured for pharmaceutical preparations, where it is used in various forms including tablets and gels.

Comment on solubility

Solubility of 2-[2-(2,2-diphenyl-1,3-dioxolan-4-yl)piperidin-1-ium-4-yl]-N,N-diethyl-ethanamine;chloride

The solubility of this compound, commonly referred to as a quaternary ammonium salt, can be influenced by several factors:

  • Polarity: Being a quaternary ammonium compound, it typically exhibits a high degree of ionic character, which often increases solubility in polar solvents such as water.
  • Hydrophilicity vs. Hydrophobicity: The presence of the diphenyl group may introduce hydrophobic characteristics, which can affect overall solubility depending on the solvent used.
  • Counterion Effects: The chloride ion (Cl-) is a small, highly soluble anion that generally enhances the solubility of the overall salt in aqueous environments.

According to the general principles of solubility, one might say, “Like dissolves like,” meaning that the compound is more likely to dissolve well in solvents that match its polarity and molecular interactions. It's notable that while the piperidine and dioxolan groups enhance potential solubility, the balance between the organic and ionic portions of the molecule dictates the compound's behavior in various solvents.

In conclusion, the solubility of 2-[2-(2,2-diphenyl-1,3-dioxolan-4-yl)piperidin-1-ium-4-yl]-N,N-diethyl-ethanamine;chloride is likely to be favorable in polar media, although care should be taken to consider its hydrophobic moieties which could limit solubility in non-polar solvents.

Interesting facts

Interesting Facts about 2-[2-(2,2-Diphenyl-1,3-dioxolan-4-yl)piperidin-1-ium-4-yl]-N,N-diethyl-ethanamine;chloride

This compound is a fascinating example of the intersection of organic chemistry and medicinal chemistry, showcasing intricate structures that can have bioactive properties. Here are some interesting aspects to consider:

  • Structural Complexity: The presence of a piperidine ring combined with a 1,3-dioxolane moiety gives this compound a unique structural make-up. Such complexity often leads to interesting interactions within biological systems.
  • Potential Biological Activity: Compounds of this nature can exhibit pharmacological activities. The piperidine structure is known to be involved in many drugs, especially those acting on neurotransmitter receptors, which highlights the potential significance of this compound in medicinal chemistry.
  • Versatile Applications: Molecules containing dioxolane functions are often utilized in synthesizing pharmaceuticals and materials due to their good reactivity. This compound might serve as a precursor or an intermediate in further drug development.
  • Chloride Salt Form: The chloride salt form of this compound indicates enhanced solubility and stability, which is advantageous for pharmacokinetics in biological systems. This can facilitate better absorption when administered, making it a subject of interest in drug formulation.
  • Potential for Research: With the rapidly advancing field of medicinal chemistry, compounds like this one can be pivotal in drug discovery, providing a groundwork for new therapeutic agents or synthetic modifications.

In conclusion, the compound 2-[2-(2,2-diphenyl-1,3-dioxolan-4-yl)piperidin-1-ium-4-yl]-N,N-diethyl-ethanamine;chloride offers a promising area for ongoing research and investigation, reflecting the beauty and complexity of organic compounds in the realm of chemistry.

Synonyms
3666-77-1
beta-4-(1-(2-Diethylaminoethyl)-2-piperidyl)-2,2-diphenyl-1,3-dioxolane dihydrochloride
1,3-Dioxolane, 4-(1-(2-diethylaminoethyl)-2-piperidyl)-2,2-diphenyl-, dihydrochloride, beta-