Skip to main content

Diclofenac

ADVERTISEMENT
Identification
Molecular formula
C14H11Cl2NO4
CAS number
15307-79-6
IUPAC name
2-[2-[(3,4-dichlorobenzoyl)amino]-5-methoxy-phenoxy]acetic acid
State
State

At room temperature, Diclofenac is in a solid state, specifically appearing as a crystalline powder.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
318.13g/mol
Molar mass
318.1320g/mol
Density
1.6000g/cm3
Appearence

Diclofenac appears as a white to off-white crystalline powder. It is odorless.

Comment on solubility

Solubility of 2-[2-[(3,4-dichlorobenzoyl)amino]-5-methoxy-phenoxy]acetic Acid

The solubility of 2-[2-[(3,4-dichlorobenzoyl)amino]-5-methoxy-phenoxy]acetic acid is influenced by its complex structure and chemical properties. As a carboxylic acid, it exhibits some degree of polarity, which can enhance solubility in polar solvents. However, several factors impact its overall solubility:

  • Polarity: The presence of the carboxylic acid group increases the polar character, potentially leading to better solubility in water compared to nonpolar organic solvents.
  • Substituents: The 3,4-dichlorobenzoyl group and methoxy group introduce steric effects and variations in hydrophobicity, which can hinder solubility.
  • pH Sensitivity: As an acid, its solubility may greatly improve in basic conditions due to deprotonation, making it more soluble in aqueous solutions.

Overall, while the compound exhibits some solubility in water due to the carboxylic acid functional group, its solubility is likely limited by the bulky chlorobenzoyl and methoxy groups. This balance between polar and nonpolar characteristics can affect how well it dissolves in various solvents, suggesting that optimal conditions for solubility might need to be explored on a case-by-case basis.

Interesting facts

Interesting Facts about 2-[2-[(3,4-dichlorobenzoyl)amino]-5-methoxy-phenoxy]acetic acid

2-[2-[(3,4-dichlorobenzoyl)amino]-5-methoxy-phenoxy]acetic acid, often referred to in scientific circles by its shorthand or its functional groups, is a fascinating compound with implications in various fields. Here are some notable aspects:

  • Biological Activity: This compound is known to exhibit interesting biological properties, particularly in the realm of pharmacology. It has been investigated for its potential as an anti-inflammatory and analgesic agent, making it a candidate for drug development.
  • Synthetic Utility: Due to its complex structure, this compound serves as an important intermediate in organic synthesis. It can be used to derive other compounds with desired biological activities.
  • Mechanism of Action: Researchers are keenly interested in the mechanism by which this compound interacts with biological targets. Studies suggest that it may modulate inflammatory pathways, highlighting its potential therapeutic uses.
  • Structure-Activity Relationship (SAR): The presence of unique functional groups, such as the dichlorobenzoyl and methoxy groups, contributes to its pharmacological properties. Exploring the SAR can lead to modifications that enhance its efficacy or reduce toxicity.
  • Environmental Impact: Investigations into the environmental persistence and toxicity of such compounds are crucial. Understanding its degradation pathways can inform safe handling and disposal practices.

As we delve deeper into the chemistry of 2-[2-[(3,4-dichlorobenzoyl)amino]-5-methoxy-phenoxy]acetic acid, the interplay of its molecular structure and biological activity continues to inspire researchers. This compound exemplifies the role of interdisciplinary approaches in the pursuit of new therapeutic avenues.

Synonyms
BRN 2399553
ACETIC ACID, (2-(3,4-DICHLOROBENZAMIDO)-5-METHOXYPHENOXY)-
6238-86-4
(2-(3,4-Dichlorobenzamido)-5-methoxyphenoxy)acetic acid
DTXSID00211437
DTXCID00133928