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Diclofenac

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Identification
Molecular formula
C14H11Cl2NO2
CAS number
15307-79-6
IUPAC name
2-[2-[(3,4-dichlorobenzoyl)amino]phenoxy]acetic acid
State
State

At room temperature, Diclofenac is in the solid state, appearing as a crystalline powder.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
273.15
Boiling point (Kelvin)
546.30
General information
Molecular weight
296.15g/mol
Molar mass
296.1490g/mol
Density
1.5120g/cm3
Appearence

Diclofenac appears as a white to slightly yellowish crystalline powder. It is odorless and is typically used in its sodium or potassium salt form to enhance solubility and absorption.

Comment on solubility

Solubility of 2-[2-[(3,4-dichlorobenzoyl)amino]phenoxy]acetic acid

The solubility of 2-[2-[(3,4-dichlorobenzoyl)amino]phenoxy]acetic acid can be influenced by several factors, including its molecular structure and the presence of functional groups. Here are some key points to consider:

  • Polarity: The compound contains both polar and nonpolar regions, which can affect its overall solubility in different solvents.
  • Hydrophilicity: The presence of the carboxylic acid group enhances its ability to interact with water, suggesting that it should have some degree of water solubility.
  • Hydrophobic Interactions: However, the chlorinated phenyl group may introduce hydrophobic characteristics that could limit solubility in aqueous environments.
  • Solvent Compatibility: It is likely to be more soluble in organic solvents (such as ethanol or DMSO) versus water.

Therefore, one could summarize its solubility behavior by stating:

"While 2-[2-[(3,4-dichlorobenzoyl)amino]phenoxy]acetic acid may exhibit moderate water solubility due to its polar functional groups, it is primarily soluble in organic solvents owing to its hydrophobic characteristics."

In conclusion, understanding the solubility of this compound is crucial for its applications in various chemical processes and formulations.

Interesting facts

Exploring 2-[2-[(3,4-dichlorobenzoyl)amino]phenoxy]acetic acid

2-[2-[(3,4-dichlorobenzoyl)amino]phenoxy]acetic acid is a fascinating compound with significant applications in various fields of research. Here are some interesting facts about it:

  • Pharmacological Potential: This compound is often studied for its potential medicinal properties, particularly in the area of therapeutic agents due to its unique functional groups.
  • Chemical Structure: The compound possesses an intriguing structure derived from both phenoxy and acetic acid functionalities, making it a subject of interest for chemists studying structure-activity relationships.
  • Environmental Impact: Compounds like this can be found in agricultural applications as herbicides or pesticides, reflecting the significant role they play in modern agriculture.
  • Research Usage: It is frequently utilized in academic and industrial research settings, particularly in organic synthesis and materials science.
  • Multifunctionality: The presence of chlorinated benzoyl groups enhances its efficacy in various biological systems, showcasing how chemical modifications can lead to improved functionality.

Scientists are continually uncovering new insights into such compounds, prompting discussions about their roles in both health and the environment. As research progresses, who knows what other exciting applications and properties might emerge for 2-[2-[(3,4-dichlorobenzoyl)amino]phenoxy]acetic acid?

Synonyms
CLAMIDOXIC ACID
Clamidoxinsaeure
Acido clamidoxico
Acide clamidoxique
Acidum clamidoxicum
6170-69-0
SNR 1804
Clamidoxic acid [INN:BAN]
Acide clamidoxique [INN-French]
Acido clamidoxico [INN-Spanish]
Acidum clamidoxicum [INN-Latin]
UNII-4H4JU6738Q
4H4JU6738Q
SNR-1804
(2-(3,4-Dichlorobenzamido)phenoxy)essigsaeure
(2-(3,4-Dichlorobenzamido)phenoxy)acetic acid
Acetic acid, (o-(3,4-dichlorobenzamido)phenoxy)-
(2-((3,4-Dichlorobenzoyl)amino)phenoxy)acetic acid
CLAMIDOXIC ACID [INN]
DTXSID30210711
Acetic acid, (2-((3,4-dichlorobenzoyl)amino)phenoxy)-
Acide clamidoxique (INN-French)
Acido clamidoxico (INN-Spanish)
Acidum clamidoxicum (INN-Latin)
DTXCID60133202
3,4-dichloro-alpha-phenoxyhippuric acid
acetic acid, ((3,4-dichlorobenzoyl)amino)phenoxy-
hippuric acid, 3,4-dichloro-alpha-phenoxy-
Clamidoxic
2-[2-[(3,4-dichlorobenzoyl)amino]phenoxy]acetic acid
SCHEMBL525147
CHEMBL2104565
NS00125520
Q27259583