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Lomotrigine

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Identification
Molecular formula
C11H16N2O2
CAS number
84057-84-1
IUPAC name
2-[2-(3,4-dimethoxyphenyl)ethyl]guanidine
State
State

At room temperature, Lomotrigine is in a solid state, specifically forming a crystalline powder. It is stable under normal conditions and must be stored in a dry environment to prevent moisture absorption.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
240.00
Boiling point (Kelvin)
513.00
General information
Molecular weight
205.26g/mol
Molar mass
205.2640g/mol
Density
1.2200g/cm3
Appearence

Lomotrigine typically appears as a white to off-white crystalline powder. It is odorless and has a bitter taste. It is hygroscopic, absorbing moisture from the air.

Comment on solubility

Solubility of 2-[2-(3,4-dimethoxyphenyl)ethyl]guanidine (C11H16N2O2)

The solubility of 2-[2-(3,4-dimethoxyphenyl)ethyl]guanidine in various solvents is influenced by its structural properties and functional groups. This compound exhibits specific behaviors in different media which can be summarized as follows:

  • Polar solvents: Compounds containing guanidine structures generally show a degree of solubility in polar solvents due to their ability to form hydrogen bonds. As a result, 2-[2-(3,4-dimethoxyphenyl)ethyl]guanidine may be moderately soluble in water.
  • Non-polar solvents: The presence of the 3,4-dimethoxyphenyl group contributes to a hydrophobic character, which means the compound might have lower solubility in non-polar solvents.
  • Solvent effects: The polarity of the solvent plays a critical role; the solubility could increase in solvents like methanol or ethanol compared to hexane due to enhanced interactions with the functional groups.

Overall, the solubility behavior of this compound could be characterized by a balance between its polar guanidine moiety and the more hydrophobic aromatic components. Understanding this solubility is essential for its applications in pharmaceuticals and medicinal chemistry, where medium choice can significantly impact efficacy and bioavailability.

Interesting facts

About 2-[2-(3,4-dimethoxyphenyl)ethyl]guanidine

2-[2-(3,4-dimethoxyphenyl)ethyl]guanidine, a compound with intriguing properties and applications, belongs to a class of organic compounds known as guanidine derivatives. Understanding this compound opens up new perspectives in both synthetic chemistry and pharmacology.

Key Facts:

  • Structural Diversity: The presence of methoxy groups on the phenyl ring allows for various electronic effects, which can significantly influence the compound's reactivity and biological activity.
  • Pharmacological Potential: Compounds like this have been investigated for their potential therapeutic effects, particularly in neuropharmacology and as antidepressants.
  • Roles in Research: Researchers often explore guanidine derivatives for their ability to modulate neurotransmitter systems, making this compound relevant in studies related to mood disorders.
  • Synthetic Relevance: The synthesis of 2-[2-(3,4-dimethoxyphenyl)ethyl]guanidine can serve as an excellent example of employing multi-step reactions to achieve complex structures in organic chemistry.
  • Biological Activity: Investigating this compound can lead to insights about activity on certain receptors in the central nervous system, which is critical for developing new medications.

As a student or scientist, exploring the functionalities of compounds like 2-[2-(3,4-dimethoxyphenyl)ethyl]guanidine not only enhances your understanding of chemistry but also provides a gateway to innovations in drug design. Each modification in its structure can lead to drastically different properties and potentials—which is a captivating aspect of organic chemistry that constantly challenges and inspires us!

Synonyms
SCHEMBL2678930
SCHEMBL13570557
AKOS009145630
CCG-248525