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Trifluoperazine

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Identification
Molecular formula
C21H24N3O2S
CAS number
117-89-5
IUPAC name
2-[2-[4-(2-methyl-3-phenothiazin-10-yl-propyl)piperazin-1-yl]ethoxy]ethanol
State
State

State: Solid at room temperature.

Melting point (Celsius)
102.50
Melting point (Kelvin)
375.65
Boiling point (Celsius)
520.00
Boiling point (Kelvin)
793.15
General information
Molecular weight
480.44g/mol
Molar mass
480.4370g/mol
Density
1.4090g/cm3
Appearence

Appearance: This compound typically appears as a white to creamy-white crystalline powder. It is often odorless and may exhibit a slightly bitter taste.

Comment on solubility

Solubility of 2-[2-[4-(2-methyl-3-phenothiazin-10-yl-propyl)piperazin-1-yl]ethoxy]ethanol

The solubility of 2-[2-[4-(2-methyl-3-phenothiazin-10-yl-propyl)piperazin-1-yl]ethoxy]ethanol in various solvents greatly influences its application and effectiveness in chemical and pharmaceutical formulations. Generally, the solubility characteristics of a compound like this can be assessed based on several factors:

  • Polarity: The presence of ethoxy and hydroxyl groups likely increases its polarity, suggesting enhanced solubility in polar solvents, such as water and alcohols.
  • Hydrogen Bonding: The compound may readily form hydrogen bonds with water molecules, which is critical for solubility in aqueous environments.
  • Chain Length: The hydrophobic phenothiazine structure could limit solubility in highly polar solvents but may still dissolve adequately in organic solvents.
  • Temperature: Solubility often increases with temperature, facilitating better dissolution in warmer environments.

In practical terms, while this compound may show good solubility in alcohols and possibly some organic solvents, it may exhibit variable solubility in aquatic systems. Thus, it can be beneficial to conduct precise solubility tests in potential solvents to determine effective use in formulations. As a general guideline, “more polar functional groups typically lead to improved solubility in polar solvents.”


Understanding the solubility behavior of this compound is essential for optimizing its performance in drug delivery systems and other applications where solubility plays a vital role.

Interesting facts

Interesting Facts about 2-[2-[4-(2-methyl-3-phenothiazin-10-yl-propyl)piperazin-1-yl]ethoxy]ethanol

This interesting compound belongs to a class of chemical substances known for their diverse applications, particularly in the field of pharmacology. Its complex structure, characterized by a phenothiazine moiety, contributes significantly to its biological activity.

Key Features:

  • Biological Importance: The compound is often investigated for its potential use as an antipsychotic agent, thanks to its ability to interact with neurotransmitter systems.
  • Research Interests: Scientists are drawn to its unique piperazine bridge, which is a common feature in many therapeutic agents, enhancing pharmacological activity.
  • Functionality: The ethoxy group within the structure plays a crucial role in solubility and bioavailability, making it a point of interest in drug formulation studies.

Moreover, the compound is an excellent example of how small modifications in chemical structure can lead to notable variations in biological effects. As researchers dive deeper into its mechanisms, they are uncovering new therapeutic pathways and potential indications.

Did You Know?

  • This compound is part of a larger family of phenothiazines, which have historically been significant in developing antipsychotic medications.
  • Phenothiazines have also shown promise in treating other conditions, such as allergies and nausea.
  • The inclusion of a piperazine derivative often enhances the selectivity of the drug, reducing side effects associated with less-specific alternatives.

In conclusion, 2-[2-[4-(2-methyl-3-phenothiazin-10-yl-propyl)piperazin-1-yl]ethoxy]ethanol is a remarkable compound with a promising future in therapeutic development. Its intricate structure and potential applications make it a fascinating topic for chemists and pharmacologists alike.

Synonyms
Dixyrazine
Esucos
Dyxirazine
Esocalm
UCB 3412
Metronal
Roscal
EINECS 219-591-3
UNII-7H368W3AYC
Esucos (TN)
BRN 0768050
7H368W3AYC
DIXYRAZINE [MI]
UCB-3412
Ethanol, 2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]-
DIXYRAZINE [MART.]
DIXYRAZINE [WHO-DD]
(2-Methyl-3-(1-hydroxyethoxyethyl-4-piperazinyl)propyl)-10-phenothiazine
10-(3-(4-Hydroxyethoxyethyl-1-piperazinyl)-2-methylpropyl)phenothiazine
J21.394B
2-(2-(4-(2-Methyl-3-phenothiazin-10-ylpropyl)-1-piperazinyl)ethoxy)ethanol
DTXSID10947639
2-(2-(4-(2-Methyl-3-(10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethoxy)ethanol
ETHANOL, 2-(2-(4-(2-METHYL-3-PHENOTHIAZIN-10-YLPROPYL)-1-PIPERAZINYL)ETHOXY)-
U. C. B. 3412
10-(2-Methyl-3-(1-hydroxyethoxyethyl-4-piperazinyl)propyl)phenothiazine
DIXYRAZINE (MART.)
Ethanol, 2-(2-(4-(2-methyl-3-(10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethoxy)-
Ethanol, 2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)-1-piperazinyl]ethoxy]-
10-[3-(4-Hydroxyethoxyethyl-1-piperazinyl)-2-methylpropyl]phenothiazine
2-[2-[4-[2-METHYL-3-(10H-PHENOTHIAZIN-10-YL)PROPYL]PIPERAZIN-1-YL]ETHOXY]ETHANOL
2-(2-(4-(2-((10H-phenothiazin-10-yl)methyl)propyl)piperazin-1-yl)ethoxy)ethan-1-ol
2-[2-(4-{2-[(10H-PHENOTHIAZIN-10-YL)METHYL]PROPYL}PIPERAZIN-1-YL)ETHOXY]ETHAN-1-OL
10-(2-methyl 3-(1-hydroxyethoxyethyl-4-piperazinyl)propyl)phenothiazine
DTXCID401375896
msyumpgngdntiq-uhfffaoysa-n
2470-73-7
2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]ethanol
Dixyrizine
Ethanol,2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]-
Dixyrazine (Standard)
SCHEMBL184504
CHEMBL3275586
CHEBI:135695
HY-U00153R
HY-U00153
AKOS027379626
CS-7192
DB13784
DA-72811
MS-27562
NS00006106
D07865
Q2759774
2-(2-(4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethoxy)ethanol #