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Trifluoperazine dihydrochloride

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Identification
Molecular formula
C21H27Cl2F3N4OS
CAS number
440-17-5
IUPAC name
2-[2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride
State
State

At room temperature, trifluoperazine dihydrochloride is typically in a solid state.

Melting point (Celsius)
263.00
Melting point (Kelvin)
536.00
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.00
General information
Molecular weight
480.38g/mol
Molar mass
480.3840g/mol
Density
1.4050g/cm3
Appearence

Trifluoperazine dihydrochloride appears as a white to off-white crystalline powder. It is typically odorless.

Comment on solubility

Solubility of 2-[2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethoxy]ethanol; dihydrochloride

This compound exhibits a fascinating profile when it comes to solubility, primarily influenced by its chemical structure and the presence of dihydrochloride salts. The solubility of 2-[2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethoxy]ethanol can be summarized as follows:

  • Aqueous solubility: Due to the presence of the dihydrochloride component, the compound is generally expected to have increased solubility in water compared to its free base form.
  • Polarity: The trifluoromethyl group and the piperazine ring contribute to the overall polarity, making the compound more soluble in polar solvents.
  • Temperature dependence: Solubility may vary with temperature; typically, higher temperatures can enhance solubility for most compounds.
  • Solvent compatibility: Besides water, the compound may show varying degrees of solubility in alcohols and other polar organic solvents. For example, it may be less soluble in non-polar solvents due to its polar functional groups.

To summarize, "the solubility of 2-[2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethoxy]ethanol; dihydrochloride is fundamentally governed by its ionic nature and polar characteristics," making it more applicable in biological systems and enhancing its interaction with polar solvents.

Interesting facts

Interesting Facts about 2-[2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride

This compound is a fascinating example of modern medicinal chemistry, particularly notable for its potential therapeutic uses. It belongs to a class of chemicals that are often explored for their activity against a range of neurological and psychiatric disorders. Here are some interesting facts:

  • Pharmacological Interest: Compounds like this one are frequently investigated for their ability to interact with neurotransmitter systems in the brain, making them candidates for treatment in **antidepressants** or **antipsychotics**.
  • Fluorinated Compounds: The presence of the trifluoromethyl group can significantly enhance the lipophilicity of the molecule, resulting in altered pharmacokinetic properties which can lead to improved efficacy and reduced side effects.
  • Phenothiazine Derivative: Phenothiazine derivatives are known for their **antipsychotic** properties, and their structure often contributes to low toxicity and a good safety profile.
  • Modular Design: The versatile design of such compounds allows for the addition of various functional groups, enabling customization of their action and results for specific therapeutic targets.

Researchers continue to explore its full potential, with studies focusing on its mechanism of action and interactions with receptor systems. As we advance our understanding of these compounds, they may pave the way for innovative treatments in mental health and beyond.

Synonyms
Fluorophenothiazine dihydrochloride
NDR A-3682
SKF 7261
SKF 7621
NSC 53638
1827-91-4
Ethanol, 2-(2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethoxy)-, dihydrochloride
Ethanol, 2-[2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethoxy]-, dihydrochloride
238A
2-[2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethoxy]ethanol dihydrochloride
M46XMH8LG5
NDR-A-3682
SKF-7621
10-{3-[1-[2-(2-Hydroxyethoxy)ethyl]-4-piperazinyl]propyl}-2-trifluoromethyl-phenothiazine, dihydrochloride