Skip to main content

Cetirizine

ADVERTISEMENT
Identification
Molecular formula
C21H25ClN2O3
CAS number
83881-52-1
IUPAC name
2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid
State
State

At room temperature, cetirizine is usually in a solid state as a crystalline powder.

Melting point (Celsius)
212.00
Melting point (Kelvin)
485.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
388.89g/mol
Molar mass
388.8880g/mol
Density
1.1940g/cm3
Appearence

Cetirizine appears as a white crystalline powder. It is generally tasteless and odorless, which makes it suitable for formulations in allergy medications.

Comment on solubility

Solubility of 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid

The solubility of 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid (C21H25ClN2O3) in various solvents can be quite insightful. Understanding its solubility characteristics is key for applications in pharmaceuticals and chemical research. Here are some aspects to consider:

  • Aqueous Solubility: Typically, compounds that contain polar functional groups, such as acids and ethers, can exhibit reasonable solubility in water. However, the overall hydrophobic nature due to the large organic framework might lead to limited solubility.
  • Organic Solvents: This compound is likely to be more soluble in organic solvents such as ethanol, dichloromethane, and dimethyl sulfoxide (DMSO) due to its hydrophobic sections.
  • pH Dependence: As a carboxylic acid, the solubility might vary significantly with pH levels. In alkaline conditions, it may ionize and enhance its water solubility; conversely, in acidic media, it may revert to its undissociated form with potentially decreased solubility.

Overall, the solubility behavior of this compound is multifaceted. As with many organic compounds, it is crucial to conduct empirical tests to determine precise solubility in various media. This can also influence its bioavailability and therapeutic effectiveness.

Interesting facts

Interesting Facts about 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid

This compound, often referred to in scientific discussions, has gained attention due to its fascinating structure and potential applications in medicinal chemistry. Here are some noteworthy aspects:

  • Complex Structure: The compound features a multifaceted structure that includes a piperazine moiety. This complexity often correlates with diverse biological activities, making it an exciting subject of study.
  • Research Applications: Its design suggests potential use in pharmacology, particularly in the development of therapeutics aimed at neurological disorders. Molecules with piperazine rings have been known to interact with neurotransmitter systems.
  • Chlorophenyl Influence: The presence of a chlorophenyl group may affect the compound's pharmacological properties by altering its interaction with biological targets. Chlorination can also enhance metabolic stability, which is crucial for drug efficacy.
  • Ethoxy Group Role: The ethoxy substituent in the structure could improve the solubility and bioavailability of the compound, key considerations in drug formulation.
  • Potential Pathways: Research continues to explore the mechanisms through which this compound could exert its effects, making it a candidate for further study in medicinal chemistry circles.

As you dive deeper into the world of chemical compounds, this particular molecule represents the intricate dance of structure and function that is fundamental to the field of pharmacology.

Synonyms
cetirizine
83881-51-0
Cetirizina
Cetryn
Ziptek
Setir
Virlix
Cetirizinum
Cetirizin
Hitrizin Film Tablet
Cetirizinum [Latin]
Cetiderm
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
AC-170
CETIRIZINE HYDROCHLORIDE
Cetirizine (INN)
UNII-YO7261ME24
CHEBI:3561
HSDB 7739
YO7261ME24
2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrichloride
(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic acid
CHEMBL1000
DTXSID4022787
Cetirizina [Spanish]
Cetirizinum (Latin)
1133210-23-7
P071
Zyrlex
774596-22-4
CETIRIZINE [INN]
(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid
Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
Acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
Cetirizine [INN:BAN]
(+/-)-(2-(4-(P-CHLORO-A-PHENYLBENZYL)-1-PIPERAZINYL)ETHOXY)ACETIC ACID
ACETIC ACID, (2-(4-((4-CHLOROPHENYL)PHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)-, (+/-)-
Cetiderm (TN)
(+/-)-Cetirizine-d4 Dihydrochloride
irizine
(R)-Cetirizine (dihydrochloride)
Benaday
Cetrizine
Humex
(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid
[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
Cetirizine (Standard)
CETIRIZINE [MI]
Prestwick0_000503
Prestwick1_000503
Prestwick2_000503
Prestwick3_000503
CETIRIZINE [HSDB]
CETIRIZINE [VANDF]
SCHEMBL4176
TimTec1_002075
CETIRIZINE [WHO-DD]
BSPBio_000425
BSPBio_002302
SPBio_002346
BPBio1_000469
DTXCID802787
GTPL1222
BDBM22890
R06AE07
ZKLPARSLTMPFCP-UHFFFAOYSA-N
HMS1539O07
HMS3259D06
HMS3370I19
HMS3393N10
BCP08787
BCP28477
IDA88151
IVB21023
BBL009968
Cet83881-51-0
HY-17042R
STK711108
[(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethyl)oxy]acetic acid
2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
AKOS003589059
AKOS021729457
AC-5545
CS-0886
DB00341
NC00696
SDCCGSBI-0206838.P002
NCGC00167781-01
NCGC00167781-02
NCGC00167781-03
NCGC00167781-04
NCGC00167781-07
NCGC00167781-12
NCGC00167781-18
AS-77105
HY-17042
SBI-0206838.P001
DB-049948
NS00000386
EN300-52521
C07778
D07662
E75781
L000655
Q423075
BRD-A42571354-300-05-4
BRD-A42571354-300-07-0
BRD-A42571354-300-11-2
BRD-A42571354-300-12-0
BRD-A42571354-300-13-8
Z754931270
[2-[4-[(4-Chlorophenyl)-phenyl methyl]-1-piperazinyl] ethoxy] acetic acid
[2-[4-[(4-chlorophenyl)phenylmethyl] 1-piperazinyl]-ethoxy] acetic acid
[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]-ethoxy]acetic acid
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)aceticacid