Interesting facts
Interesting Facts about 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol
This compound is a fascinating member of the class of compounds known as piperazine derivatives. It showcases a unique combination of pharmacological properties due to its intricate molecular structure. Here are some intriguing points about it:
- Piperazine Backbone: The presence of the piperazine moiety contributes significantly to the compound's activity. Piperazines are known for their roles in various receptor interactions, making them key players in therapeutic formulations.
- Chlorophenyl Group: The incorporation of a chlorophenyl substituent enhances the compound's lipophilicity and influences its biological interactions. Chlorinated aromatic compounds are often noted for their improved binding affinities in biological systems.
- Potential Pharmacological Applications: Compounds of this nature are often studied for their potential use in treating conditions such as depression, anxiety, and other mood disorders. Their ability to modulate neurotransmitter levels makes them a point of interest in medicinal chemistry.
- Structure-Activity Relationship (SAR): The structure of this compound offers rich possibilities for SAR studies, which can help researchers understand how modifications can enhance efficacy and reduce side effects.
- Complex Synthesis: The synthesis of this compound involves several steps that require precise control of reaction conditions, highlighting the complexity of creating targeted pharmaceutical agents in the lab.
In conclusion, 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol is not just a chemical entity; it represents a synthesis of design, therapeutic potential, and the ongoing quest for innovative solutions in pharmacology. The study of such compounds continues to unfold exciting opportunities in drug discovery.
Synonyms
hydroxyzine
68-88-2
Hydroxizine
Hydroxyzin
Hydroxine
Hydroxycine
Tranquizine
Ataraxoid
Hychotine
Hydroxizinum
Tran-Q
Atarazoid
Neurozina
Nevrolaks
Traquizine
Atazina
Deinait
Pamazone
Placidol
Plaxidol
Atara
Atarox
Aterax
neo-Calma
Atarax
Idrossizina
Parenteral
Paxistil
Vesparaz-Wirkstoff
Atarax base
Vistaril
Hidroxizina
Hydroxyzinum
Hydroksyzyny
Hydroxyzyne
Idrossizina [DCIT]
Hydroksyzyny [Polish]
Hydroxyzine base
Hydroxyzinum [INN-Latin]
Hidroxizina [INN-Spanish]
UCB 492
NP 212
Hydroxyzine free base
U.C.B 4492
Hydroxyzine hydrochloride
UCB 4492
U.CB 4492
HSDB 3098
N-(4-Chlorobenzhydryl)-N'-(hydroxyethoxyethyl)piperazine
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol
Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
EINECS 200-693-1
1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine
UNII-30S50YM8OG
Hydroxyzine (INN)
NSC 169188
NSC-169188
BRN 0321392
30S50YM8OG
CHEBI:5818
1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
DTXSID8023137
1-(p-Chlorodiphenylmethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
U.c.b-4492
N-(4-Chlorobenzhydryl)-N'-(hydroxyethyloxyethyl)piperazine
CHEMBL896
1-(p-Chloro-alpha-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine
2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol
2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol
2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol
(+/-)-HYDROXYZINE
1-(p-Chloro-alpha-phenylbenzyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
68-88-2 (free base)
DTXCID203137
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol
5-23-01-00462 (Beilstein Handbook Reference)
Ethanol, 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-
Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol
NSC169188
NCGC00018255-04
Vistaril Parenteral
HYDROXYZINE [INN]
2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol
Hydroxyzinum (INN-Latin)
Hidroxizina (INN-Spanish)
Hydroxyzine [INN:BAN]
HYDROXYZINE (MART.)
HYDROXYZINE [MART.]
1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine
1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine
1-(p-Chlorodiphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine
2-(2-(4-(p-Chloro-.alpha.-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol
2-[2-[4-(p-Chloro-.alpha.-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol
1-(p-Chloro-.alpha.-phenylbenzyl)-4-[2-[(2-hydroxyethoxy)ethyl]piperazine
2-(2-{4-[(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-ethanol
Ethanol, 2-[2-[4-(p-chloro-.alpha.-phenylbenzyl)-1-piperazinyl]ethoxy]-
CAS-68-88-2
ETHANOL, 2-(2-(4-((4-CHLOROPHENYL)PHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)-,(+/-)-
Marex (TN)
idroxizina
1-(p-Chloro-.alpha.-phenylbenzyl)-4-(2-((2-hydroxyethoxy)ethyl)piperazine
Hydroxyzine, (R)
Atarax (Salt/Mix)
Disron (Salt/Mix)
Durrax (Salt/Mix)
MFCD00242772
MULTIPAX
ORGATAX
ULGRAX
Vistaril (Salt/Mix)
Hydroxyzine (Standard)
HYDROXYZINE [MI]
Prestwick0_000133
Prestwick1_000133
Prestwick2_000133
Prestwick3_000133
2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol
HYDROXYZINE [HSDB]
HYDROXYZINE [VANDF]
SCHEMBL4491
BSPBio_000206
HYDROXYZINE [WHO-DD]
SPBio_002145
BPBio1_000228
GTPL7199
BDBM22875
HY-B0548R
N05BB01
HMS3604B10
HY-B0548
PXB48047
UCB-4492
1-(P-CHLOROBENZHYDRYL)-4-
Tox21_113569
BBL034752
STL417960
2-[(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethyl)oxy]ethanol
AKOS003334349
AKOS016843978
Tox21_113569_1
DB00557
1-(P-CHLORODIPHENYLMETHYL)-4-
MRF-0000015
NCGC00018255-02
NCGC00018255-03
NCGC00018255-06
NCGC00021152-06
NCGC00089816-03
AS-81900
WLN: T6N DNTJ AYR&R D6& D2O2Q
DB-049942
AB00053485
NS00002988
C07045
D08054
EN300-708786
W13117
AB00053485_24
AB00053485_25
L000930
Q421937
BRD-A62428732-096-02-6
BRD-A62428732-096-10-9
BRD-A62428732-300-03-0
BRD-A62428732-300-06-3
1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine)
1-(p-Chloro-?-phenylbenzyl)-4-[2-(2-hydroxyethoxy)ethyl)]piperazine
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)-piperazin-1-yl)ethoxy)ethanol
2-(2-(4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl)ethoxy)ethanol #
(+/-)-2-(2-(4-(P-CHLORO-.ALPHA.-PHENYLBENZYL)-1-PIPERAZINYL)ETHOXY)ETHANOL
(+/-)-2-(2-(4-(P-CHLORO-alpha-PHENYLBENZYL)-1-PIPERAZINYL)ETHOXY)ETHANOL
1-(P-CHLORO-.ALPHA.-PHENYLBENZYL)-4-(2-((2-HYDROXYETHOXY)ETHYL))PIPERAZINE
1-(P-CHLORO-alpha-PHENYLBENZYL)-4-(2-((2-HYDROXYETHOXY)ETHYL))PIPERAZINE
ETHANOL, 2-(2-(4-(4-CHLORO-.ALPHA.-PHENYLBENZYL)-1-PIPERAZINYL)ETHOXY)-
ETHANOL, 2-(2-(4-(4-CHLORO-alpha-PHENYLBENZYL)-1-PIPERAZINYL)ETHOXY)-
200-693-1
Solubility of 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol
The solubility of the compound 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol (C21H25ClN2O3) can be quite intriguing due to its complex structure and functional groups. This compound presents a mixture of hydrophobic and hydrophilic characteristics, impacting its solubility in various solvents.
Key solubility factors:
In summary, while the compound is expected to show some degree of solubility in polar solvents due to its functional groups, the overall solubility profile is likely to be moderate, influenced by the balance between its hydrophilic and hydrophobic features. As a result, experimental determination is essential for accurate insights into its solubility behavior.