Skip to main content

Fenclofenac

ADVERTISEMENT
Identification
Molecular formula
C16H14ClNO4
CAS number
3845-40-3
IUPAC name
2-[2-[(4-chlorobenzoyl)amino]-4-methyl-phenoxy]acetic acid
State
State

Fenclofenac is a solid at room temperature.

Melting point (Celsius)
201.50
Melting point (Kelvin)
474.70
Boiling point (Celsius)
427.50
Boiling point (Kelvin)
700.60
General information
Molecular weight
305.75g/mol
Molar mass
305.7530g/mol
Density
1.4050g/cm3
Appearence

Fenclofenac appears as a white crystalline powder. It is typically odorless and has a bitter taste.

Comment on solubility

Solubility of 2-[2-[(4-chlorobenzoyl)amino]-4-methyl-phenoxy]acetic acid

The solubility of 2-[2-[(4-chlorobenzoyl)amino]-4-methyl-phenoxy]acetic acid can be quite complex due to its molecular structure and functional groups. Here are some key points to consider:

  • Polarity: The presence of both hydrophobic phenyl rings and hydrophilic -COOH (carboxylic acid) groups suggests that this compound can exhibit both polar and nonpolar characteristics.
  • pH Dependence: The solubility is likely to be pH-dependent. At lower pH levels, the -COOH group is protonated, potentially reducing solubility in water. As pH increases and the group ionizes, solubility may increase.
  • Solvent Compatibility: This compound may have higher solubility in organic solvents like ethanol or DMSO compared to water due to its hydrophobic components.
  • Temperature Effects: Higher temperatures can increase solubility by providing more energy for molecules to overcome intermolecular forces, which is particularly relevant for semicrystalline compounds.

As a result, understanding the solubility characteristics is crucial for applications in pharmaceuticals, where solubility can influence bioavailability and drug formulation.

Interesting facts

Interesting Facts about 2-[2-[(4-chlorobenzoyl)amino]-4-methyl-phenoxy]acetic Acid

2-[2-[(4-chlorobenzoyl)amino]-4-methyl-phenoxy]acetic acid, often referred to in scientific literature as an active pharmaceutical compound, showcases several compelling characteristics:

  • Pharmacological Significance: This compound is studied for its potential applications in various therapeutic areas, including its role in anti-inflammatory and analgesic effects. Its unique structure allows it to interact with biological systems in a significant way.
  • Synthetic Pathways: The synthesis of this compound involves several intricate steps that highlight the beauty of organic chemistry. Researchers often explore new methods to enhance yield and purity during its production.
  • Structure-Activity Relationship (SAR): Understanding how modifications to the chemical structure can influence the compound's biological properties is a crucial area of research. For example, the presence of the 4-chlorobenzoyl moiety is believed to play a key role in the compound's efficacy.
  • Environmental Impact: As with many pharmaceuticals, understanding the environmental fate of this compound is essential. Its stability and degradation in various conditions can help inform its safe usage and disposal.
  • Interdisciplinary Applications: This compound lends itself to studies that intersect with fields like biochemistry, molecular biology, and pharmacology, making it a subject of interest across various scientific disciplines.

"The interface between structure and activity in pharmacologically significant compounds remains one of the most fascinating aspects of modern chemistry."

The exploration of 2-[2-[(4-chlorobenzoyl)amino]-4-methyl-phenoxy]acetic acid exemplifies the intricate relationship between chemical structure and biological function, underscoring the importance of diligent research and innovative thinking in chemistry.

Synonyms
BRN 2395081
ACETIC ACID, ((2-(p-CHLOROBENZAMIDO)-p-TOLYL)OXY)-
6239-19-6
((2-(p-Chlorobenzamido)-p-tolyl)oxy)acetic acid
DTXSID50211442
DTXCID50133933