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Tropisetron

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Identification
Molecular formula
C19H22ClNO2
CAS number
105826-92-4
IUPAC name
2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;4-hydroxy-4-oxo-but-2-enoate
State
State

At room temperature, tropisetron is in a solid state, generally provided in its hydrochloride crystalline form for stability and solubility in medical formulations.

Melting point (Celsius)
246.00
Melting point (Kelvin)
519.00
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.00
General information
Molecular weight
385.88g/mol
Molar mass
385.8820g/mol
Density
1.3300g/cm3
Appearence

Tropisetron is usually observed as a white to off-white crystalline powder. It is often prepared in its hydrochloride form for medical use, which is also a crystalline solid.

Comment on solubility

Solubility of 2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;4-hydroxy-4-oxo-but-2-enoate

The compound 2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;4-hydroxy-4-oxo-but-2-enoate has a complex structure that impacts its solubility in various solvents. When considering the solubility factors, it is beneficial to note several key points:

  • Polarity: The presence of multiple functional groups, including dimethoxy and hydroxy, suggest that the compound may exhibit both polar and non-polar characteristics.
  • Solvent Interaction: It is likely to be more soluble in polar solvents such as water or methanol due to its ionic nature, while its lipophilic portions may enhance solubility in organic solvents.
  • pH Dependency: The solubility may also vary with pH levels; the ionization of certain groups may lead to increased solubility in acidic or basic conditions.
  • Temperature Influence: Elevated temperatures may enhance the solubility by increasing molecular motion, facilitating interactions with the solvent.

In summary, the solubility of this compound is influenced by its intricate chemical structure and the nature of the solvents used. As the saying goes, "like dissolves like," hence understanding the interplay between its polar and non-polar regions is crucial for predicting its solubility behavior. Overall, experimental determination is essential for obtaining precise solubility data, as theoretical predictions can only provide a general guideline.

Interesting facts

Interesting Facts about 2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium; 4-hydroxy-4-oxo-but-2-enoate

This compound is a fascinating molecule due to its complex structure and potential biological activity. Here are some intriguing aspects:

  • Pharmacological Potential: The isoquinoline core, common in many alkaloids, often correlates with a variety of biological activities. Compounds like this one could have potential uses in the pharmaceutical field, particularly in the development of medications targeting neurological conditions or cancers.
  • Substituent Influence: The presence of the 4-chlorophenyl group can significantly affect the electronic properties and biological behavior of the molecule. This modification can enhance lipophilicity, influencing the compound's ability to cross lipid membranes, which is crucial for drug activity.
  • Mechanistic Studies: The interaction of this compound with biological targets can be studied through various mechanisms, facilitating insights into how modifications alter pharmacodynamics and pharmacokinetics.
  • Natural Products Inspiration: Its structure showcases the importance of natural products in medicinal chemistry, as many drugs are derived or inspired by natural molecules found in plants, fungi, and other organisms, reflecting their significant role in drug discovery.
  • Synthetic Chemistry: The complexities involved in synthesizing such compounds highlight advancements in organic synthesis techniques, including the use of underutilized reagents or novel catalytic methods, showcasing creativity and innovation in the field.

In summary, the study of this compound not only opens doors to understanding its potential therapeutic applications but also emphasizes broader themes in chemical research such as structure-activity relationships and the quest for novel therapeutic agents. As one researcher aptly stated, “The beauty of chemistry lies in the infinite possibilities of synthesis and the unexpected properties waiting to be uncovered.”