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Clorazapine

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Identification
Molecular formula
C19H22ClNO2
CAS number
5786-21-0
IUPAC name
2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline
State
State
Solid at room temperature with a pale yellowish color.
Melting point (Celsius)
190.50
Melting point (Kelvin)
463.70
Boiling point (Celsius)
456.60
Boiling point (Kelvin)
729.80
General information
Molecular weight
334.85g/mol
Molar mass
334.8310g/mol
Density
1.2250g/cm3
Appearence

Clorazapine typically appears as a pale yellow solid in its pure form.

Comment on solubility

Solubility of 2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline

The solubility of 2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline is a vital aspect to consider, especially when examining its potential applications in pharmaceuticals and materials science. Its solubility characteristics can be influenced by various factors, including:

  • Polarity: The presence of multiple methoxy groups increases the compound's polarity, which may enhance its solubility in polar solvents.
  • Interactions: Hydrogen bonding and van der Waals interactions can play a crucial role in determining solubility in different mediums.
  • Temperature: Like many organic compounds, increased temperature can potentially increase solubility, leading to better dissolution rates.
  • pH Level: The acidity or basicity of the solution can also affect how well this compound dissolves, particularly if ionizable groups are present.

In general, this compound may exhibit moderate solubility in solvents such as ethanol and DMSO due to hydrophobic interactions and the overall balance of polar and non-polar characteristics. However, it may have limited solubility in pure water, highlighting the *importance of solvent selection* in experimental applications.

As a concluding thought, understanding and manipulating the solubility of 2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline can significantly enhance its functionality and effectiveness in various chemical processes.

Interesting facts

Interesting Facts about 2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline

This compound is a fascinating example of an isoquinoline derivative, known for its potential biological activities. Isoquinoline structures are commonly found in various natural products and have garnered significant interest in medicinal chemistry. Here are some intriguing points about this compound:

  • Pharmacological Potential: Derivatives of isoquinoline, such as this one, have shown promise as therapeutic agents. They may exhibit a range of biological activities, including anti-inflammatory, analgesic, and antitumor effects.
  • Structural Complexity: The presence of a 4-chlorophenyl group and methoxy substituents at specific positions enhances its complexity, potentially influencing how it interacts with biological targets.
  • Aromaticity: The compound's aromatic systems contribute to its stability and biological interactions, making it a subject of study in various chemical fields.
  • Research Applicability: Isoquinoline derivatives are often investigated in the context of neuropharmacology, offering insights into central nervous system disorders. This compound could serve as a scaffold for developing new therapeutic agents.
  • Natural Products Connection: Many isoquinoline alkaloids are derived from plant sources, illustrating the connection between natural compounds and synthetic derivatives in drug discovery.

In summary, this compound exemplifies the rich chemistry of isoquinolines, making it a valuable subject for research in medicinal chemistry and pharmacology. As scientists continue to explore its properties, the potential applications in drug development are abundant and exciting.

Synonyms
2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
MLS001179534
SMR000476995
AM-814/41093239
CHEMBL1740602
SCHEMBL23054187
BDBM94522
cid_23723130
2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline
SR-01000846282
SR-01000846282-2
(Z)-2-butenedioic acid;2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline
(Z)-but-2-enedioic acid;2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline
2-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline;maleic acid