Skip to main content

Closantel

ADVERTISEMENT
Identification
Molecular formula
C22H13Cl2N3O2S2
CAS number
61438-64-0
IUPAC name
2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid
State
State

At room temperature, closantel is found as a solid.

Melting point (Celsius)
216.00
Melting point (Kelvin)
489.15
Boiling point (Celsius)
434.50
Boiling point (Kelvin)
707.70
General information
Molecular weight
663.07g/mol
Molar mass
663.0700g/mol
Density
1.4200g/cm3
Appearence

Closantel typically appears as a yellow crystalline powder. The hue and crystalline nature can vary slightly based on purity and form.

Comment on solubility

Solubility of 2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid

The solubility of 2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid can be influenced by various factors, making it a compound of interest in the realm of chemical studies. Here are some key points regarding its solubility:

  • Polarity: The presence of both a chlorophenyl group and a thiazole ring contributes to the compound's overall polarity, which can enhance its solubility in polar solvents.
  • Hydrogen Bonding: The carboxylic acid group (-COOH) allows for the potential formation of hydrogen bonds with solvents, thereby increasing solubility in protic solvents like water.
  • Temperature Dependence: As is common with many organic compounds, solubility may increase with temperature. Thus, higher temperatures may lead to a greater dissolution in solvent mediums.
  • pH Influence: The solubility of acids is often pH-dependent; a more acidic environment can promote the ionization of the carboxylic group, thereby enhancing solubility.

In summary, the solubility of 2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid appears to be significantly affected by its molecular structure and the environmental conditions under which solubility is being measured. Understanding these characteristics is crucial for applications in pharmaceuticals and chemical synthesis.

Interesting facts

Exploring 2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid

2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid is a unique compound with intriguing properties and potential applications in various fields.

Chemical Structure and Characteristics

This compound features a thiazole ring fused with a 4-chlorophenyl group, making it a subject of interest in medicinal chemistry. The thiazole moiety is well-known for its role in various biologically active compounds, illustrating the importance of heterocycles in drug design.

Biological Significance

Here are some noteworthy points about 2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid:

  • Pharmacological Potential: The thiazole component is often associated with anti-inflammatory, antimicrobial, and anticancer properties, which makes this compound an attractive candidate for pharmaceutical exploration.
  • Mechanisms of Action: Research suggests that compounds with thiazole scaffolds may influence enzymes and receptors in the body, providing avenues for the development of new therapeutic agents.
  • Chlorine Substitution: The presence of the 4-chlorophenyl group can enhance the lipophilicity and the overall bioavailability of the compound, potentially leading to improved pharmacokinetic profiles.

Applications in Research

The diverse functionalities of 2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid open up numerous avenues for scientific investigation:

  • Drug Development: Researchers can explore its efficacy as a lead compound for new drugs targeting various conditions.
  • Biochemistry Studies: Understanding how this compound interacts with biological systems can yield valuable insights into metabolic pathways and disease mechanisms.
  • Material Science: The properties of thiazole derivatives have implications beyond biology; they may be utilized in developing advanced materials.

In conclusion, 2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid exemplifies the intricate relationship between chemical structure and biological function, showcasing the potential of thiazole derivatives in scientific research and drug discovery. As a compound rich in possibilities, it serves as a reminder of the endless opportunities that chemical investigation can unveil.

Synonyms
Fenclozic acid
17969-20-9
Acido fenclozico
Acidum fenclozicum
Acide fenclozique
ICI-54450
58SRQ4DV53
DTXSID4046157
I.C.I. 54,450
DTXCID2026157
ICI-54,450
2-(4-chlorophenyl)-4--thiazoleacetic acid
2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid
4-Thiazoleacetic acid, 2-(4-chlorophenyl)-
Mialex
2-(2-(4-Chlorophenyl)thiazol-4-yl)acetic acid
Myalex
[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
ICI 54450
MFCD00721754
ICI 54,450
2-(p-Chlorophenyl)-4-thiazoleacetic acid
2-(p-Chlorophenyl)thiazol-4-ylacetic acid
2-(4-Chlorophenyl)-thiazol-4-ylacetic acid
4-THIAZOLEACETIC ACID, 2-(p-CHLOROPHENYL)-
Acide p-chlorophenyl-2 thiazole-acetique-4
NCGC00160449-01
ICI54450;ICI-54450;Acidum fenclozicum; Fenclozic acid; Mialex; Myalex
Acido fenclozico [Italian]
CAS-17969-20-9
Acide fenclozique [INN-French]
Acido fenclozico [INN-Spanish]
Acidum fenclozicum [INN-Latin]
2-[2-(4-chlorophenyl)thiazol-4-yl]acetic acid
Fenclozic acid [INN:BAN]
BRN 0528088
UNII-58SRQ4DV53
2-(4-Chlorophenyl)-4-thiazoleacetic acid
2-(p-Chlorophenyl)-4-thiazole-acetic acid
Acide p-chlorophenyl-2 thiazole-acetique-4 [French]
CBMicro_029727
2-(2-(4-Chlorophenyl)thiazol-4-yl)aceticacid
FENCLOZIC ACID [MI]
Oprea1_306382
SCHEMBL27104
FENCLOZIC ACID [INN]
MLS004754493
orb1298780
CHEMBL1909282
ALBB-015584
Tox21_111819
BBL028894
BDBM50103519
SBB053159
STK719736
AKOS000348563
Tox21_111819_1
8L-323S
2-(p-Chlorphenyl)-4-thiazoleacetic acid
NCGC00160449-02
NCGC00160449-03
NCGC00160449-04
FC124498
SMR002529997
BIM-0029456.P001
2-(4'-Chlorophenyl)thiazole-4-acetic acid
2-(4-Chlorophenyl)-4-thiazole-acetic acid
2-(4-Chlorophenyl)thiazol-4-ylacetic acid
DB-044375
HY-101432
CS-0021323
ST50949622
2-(4-chlorophenyl) thiazol-4-yl acetic acid
EN300-11448
D83848
SR-01000883990
Q5443206
SR-01000883990-1
BRD-K90137436-001-01-8
Z57046959
[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid #
2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid, AldrichCPR