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Etomidate

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Identification
Molecular formula
C19H23N3O2
CAS number
33125-97-2
IUPAC name
2-[2-(4-ethoxyphenoxy)benzimidazol-1-yl]-N,N-diethyl-ethanamine
State
State

Etomidate is typically encountered as a liquid in its drug solution form, but the pure compound can be a crystalline solid. It is administered in solution form.

Melting point (Celsius)
80.00
Melting point (Kelvin)
353.15
Boiling point (Celsius)
390.00
Boiling point (Kelvin)
663.15
General information
Molecular weight
344.42g/mol
Molar mass
344.4240g/mol
Density
1.2000g/cm3
Appearence

Etomidate typically appears as a colorless or slightly yellowish liquid, although it can also be encountered as a crystalline powder. It is formulated for use as an aqueous solution for intravenous injection. The solution is generally clear and free of particles.

Comment on solubility

Solubility of 2-[2-(4-ethoxyphenoxy)benzimidazol-1-yl]-N,N-diethyl-ethanamine

The solubility of 2-[2-(4-ethoxyphenoxy)benzimidazol-1-yl]-N,N-diethyl-ethanamine can be quite complex due to its structural characteristics. This compound features multiple moieties that influence its solubility in various solvents.

Key Points to Consider:

  • Polarity: The presence of the ethoxy group and the benzimidazole ring suggests a degree of polarity, which may favor solubility in polar solvents.
  • Hydrophobic Interactions: The diethyl amino group contributes to hydrophobic characteristics, potentially enhancing solubility in organic solvents.
  • Temperature Effects: Solvent temperature can greatly affect solubility; generally, higher temperatures increase solubility for many compounds.
  • pH Sensitivity: The solubility may also be pH-dependent, especially given the amine functional groups, which can acquire positive charges in acidic environments.

In summary, the solubility of 2-[2-(4-ethoxyphenoxy)benzimidazol-1-yl]-N,N-diethyl-ethanamine is influenced by a blend of its polar and non-polar interactions. It is crucial to explore specific conditions and solvents to determine the most suitable environment for effective dissolution. As noted, “material solubility is a dance of molecular interactions,” highlighting the dynamic nature of these properties.

Interesting facts

Interesting Facts about 2-[2-(4-ethoxyphenoxy)benzimidazol-1-yl]-N,N-diethyl-ethanamine

2-[2-(4-ethoxyphenoxy)benzimidazol-1-yl]-N,N-diethyl-ethanamine is a fascinating compound with a range of intriguing features:

  • Multifunctionality: This compound contains a benzimidazole core, which is known for its versatility. Compounds with benzimidazole moieties are often investigated for their potential applications in medicinal chemistry, particularly as antimicrobial agents and anticancer drugs.
  • Hybrid Structure: The presence of the ethoxyphenoxy group adds another layer of functionality to this compound. The combination of different structural motifs can lead to enhanced biological activity and improved solubility properties.
  • Potential Applications: Due to its unique structure, this compound may act on various biological targets. Researchers are interested in exploring its capabilities as a novel therapeutic agent, particularly in the fields of pharmacology and medicinal chemistry.
  • Research Interest: Compounds with similar structures have been the focus of numerous studies aimed at understanding their pharmacokinetics and pharmacodynamics, which can provide insights into how these compounds interact within biological systems.
  • In the Lab: This compound serves as an excellent example of how chemical structural complexity can influence biological behavior. Chemists and biologists alike utilize such compounds to elucidate mechanisms of action, develop targeted therapies, and enhance drug delivery systems.

In summary, 2-[2-(4-ethoxyphenoxy)benzimidazol-1-yl]-N,N-diethyl-ethanamine stands out not only due to its structural novelty but also for its potential impact on drug development and therapeutic applications. As research in this area continues to evolve, it may pave the way for novel treatments for challenging diseases.

Synonyms
BRN 0899120
3308-28-9
BENZIMIDAZOLE, 1-(2-(DIETHYLAMINO)ETHYL)-2-(p-ETHOXYPHENOXY)-
1-(2-(Diethylamino)ethyl)-2-(p-ethoxyphenoxy)benzimidazole
DTXSID80186730
5-23-11-00261 (Beilstein Handbook Reference)
DTXCID20109221
2-[2-(4-Ethoxyphenoxy)-1H-benzimidazol-1-yl]-N,N-diethylethanamine