Nifurtimox | Solubility of Things

Identification

Molecular formula

C₁₂H₁₃N₃O₅

CAS number

23256-30-6

IUPAC name

2-[2-[5-(dihydroxyamino)-2-furyl]vinyl]-N-imino-quinoline-4-carboxamide

State

Nifurtimox is primarily in the form of a solid at room temperature. It is often formulated into tablets for medicinal use.

Melting point (Celsius)

201.00

Melting point (Kelvin)

474.15

Boiling point (Celsius)

420.00

Boiling point (Kelvin)

693.15

General information

Molecular weight

287.25g/mol

Molar mass

287.2690g/mol

Density

1.5100g/cm³

Appearence

Nifurtimox typically appears as a yellow to orange solid powder. It may appear crystalline in nature and sensitive to moisture and light.

Comment on solubility

Solubility of 2-[2-[5-(dihydroxyamino)-2-furyl]vinyl]-N-imino-quinoline-4-carboxamide

The compound 2-[2-[5-(dihydroxyamino)-2-furyl]vinyl]-N-imino-quinoline-4-carboxamide, with the chemical formula C₁₂H₁₃N₃O₅, exhibits intriguing solubility characteristics that warrant careful consideration. Understanding the solubility behavior of a compound is essential in various applications, including pharmaceuticals and materials science.

Key Factors Influencing Solubility:

Polarity: The presence of polar functional groups such as hydroxyl (-OH) contributes to the compound's ability to interact with polar solvents, potentially enhancing its solubility in water.
Hydrogen Bonding: Dihydroxyamino and carboxamide groups may facilitate hydrogen bonding with solvent molecules, possibly leading to increased solubility in aqueous solutions.
Structural Configuration: The rigid quinoline backbone may influence how well the compound packs in a solid state, affecting its dissolution process when interacting with solvents.

In general, compounds with similar structures tend to display variations in solubility based on their chemical composition and environmental conditions. A notable trend is that compounds containing multiple polar groups often exhibit higher solubility in polar solvents like water, while those with more non-polar characteristics might prefer organic solvents.

To summarize, the solubility of 2-[2-[5-(dihydroxyamino)-2-furyl]vinyl]-N-imino-quinoline-4-carboxamide may be influenced by its multifunctional polar groups—making it potentially soluble in polar solvents. However, its exact solubility profile would require experimental determination to ascertain specific behavior in various solvents.

Interesting facts

Interesting Facts about 2-[2-[5-(dihydroxyamino)-2-furyl]vinyl]-N-imino-quinoline-4-carboxamide

The compound 2-[2-[5-(dihydroxyamino)-2-furyl]vinyl]-N-imino-quinoline-4-carboxamide is not just a complex molecular structure; it embodies a wealth of intriguing properties and potential applications. Here are some key facts:

Biological Significance: This compound features the quinoline moiety, which has been extensively studied for its biological activity, including antimicrobial and anticancer properties.
Furyl Group: The presence of the furyl group contributes to its diverse chemical behavior, making it an interesting subject of study in organic synthesis.
Hydroxyl Functionality: The dihydroxyamino substituent enhances the hydrogen bonding capacity of the molecule, which can affect its solubility and interaction with biological targets.
Potential in Medicine: Researchers are exploring this compound's potential as a lead compound for developing new drugs, particularly due to its unique structure that may interact effectively with certain biological pathways.
Material Science Applications: Beyond pharmaceuticals, compounds like this one can also serve as dyes or ligands in coordination chemistry, making them useful in material science.

As a chemistry student, understanding the structure-function relationship in such compounds is crucial. The intricate arrangement of atoms within this molecule makes it a fascinating subject for further research. The ability to modify such compounds could pave the way for breakthroughs in therapeutics and sustainable materials. “Chemistry is not just the study of matter, but the study of change.” - Walter White

Thus, the exploration of 2-[2-[5-(dihydroxyamino)-2-furyl]vinyl]-N-imino-quinoline-4-carboxamide holds promise not just for practical applications but also for contributing to the overall understanding of complex organic compounds.