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Nitazoxanide

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Identification
Molecular formula
C12H9N3O5S
CAS number
55981-09-4
IUPAC name
2-[2-[(5-nitrothiazol-2-yl)amino]-4,5-dihydroimidazol-1-yl]ethanol
State
State

At room temperature, Nitazoxanide is in a solid state. It is usually prepared in the form of tablets or suspensions for therapeutic use.

Melting point (Celsius)
202.00
Melting point (Kelvin)
475.15
Boiling point (Celsius)
593.40
Boiling point (Kelvin)
866.55
General information
Molecular weight
307.29g/mol
Molar mass
307.2850g/mol
Density
1.4740g/cm3
Appearence

Nitazoxanide is a crystalline powder that is pale yellow in color. It is often found as solid crystals or crystalline powder for pharmaceutical preparations.

Comment on solubility

Solubility of 2-[2-[(5-nitrothiazol-2-yl)amino]-4,5-dihydroimidazol-1-yl]ethanol

The solubility of 2-[2-[(5-nitrothiazol-2-yl)amino]-4,5-dihydroimidazol-1-yl]ethanol is influenced by various factors, including its chemical structure and environmental conditions. Generally, this compound is expected to exhibit moderate solubility characteristics due to the following reasons:

  • Polarity: The presence of polar functional groups like hydroxyl (-OH) makes it likely to have some affinity for polar solvents such as water.
  • Hydrogen Bonding: The compound can participate in hydrogen bonding interactions, enhancing its solubility in water.
  • Hydrophobic Regions: The thiazole and imidazole groups may introduce hydrophobic characteristics that can limit solubility in highly polar solvents.

Moreover, the solubility can be affected by parameters such as:

  1. Temperature: Higher temperatures usually increase solubility due to enhanced molecular motion.
  2. pH Level: Changes in pH can alter the ionization state of the compound, thus affecting solubility.
  3. Presence of Other Solvents: Co-solvents may modify the solubility profile, making it more favorable in mixed solvent systems.

In summary, while 2-[2-[(5-nitrothiazol-2-yl)amino]-4,5-dihydroimidazol-1-yl]ethanol may display moderate solubility, understanding the specific conditions and interactions at play will provide a clearer image of its behavior in solution. As the saying goes, "The devil is in the details," especially when it comes to solubility.

Interesting facts

Interesting Facts about 2-[2-[(5-nitrothiazol-2-yl)amino]-4,5-dihydroimidazol-1-yl]ethanol

This compound, known for its intriguing structure and potential applications, is a fascinating subject in the field of medicinal chemistry. The presence of a nitrothiazole ring adds a unique profile to this molecule, making it a candidate of interest for various biological studies.

1. Structural Significance

  • Nitrothiazole moiety: The nitrothiazole group is often associated with antimicrobial properties, which is why this compound may be studied for its pharmacological effects.
  • Imidazole ring: The imidazole segment contributes to the compound's ability to act as a biological ligand, binding to various targets in biological systems.
  • Alcohol functional group: The ethanol part of the molecule plays a crucial role in solubility and interactions, potentially enhancing the bioavailability of the compound.

2. Biological Potential

This compound is under investigation for its potential therapeutic applications, particularly in:

  • Antimicrobial agents: Given the presence of the nitrothiazole group, it may exhibit activity against bacterial and fungal strains.
  • Antiparasitic properties: Some studies suggest that similar compounds can disrupt the life cycle of certain parasites.
  • Enzyme inhibitors: The imidazole and amino functionalities could allow the compound to interact with key enzymes involved in disease processes.

3. Synthesis and Modification

Advancements in synthetic methodologies have made it easier to modify the structure of this compound. Scientists explore various derivatives to:

  • Enhance efficacy
  • Reduce toxicity
  • Improve pharmacokinetic properties

4. Research Implications

As researchers continue to investigate compounds like 2-[2-[(5-nitrothiazol-2-yl)amino]-4,5-dihydroimidazol-1-yl]ethanol, we may see breakthroughs in:

  • Novel therapeutic agents for resistant microbial strains
  • New pathways in drug design and discovery

In conclusion, the complexity and potential of this chemical compound make it a beacon of hope in medicinal chemistry, *inviting further exploration* and *innovation* in drug development.

Synonyms
BRN 5390465
1-IMIDAZOLIDINEETHANOL, 2-((5-NITRO-2-THIAZOLYL)IMINO)-
DTXSID60178936
2-((5-Nitro-2-thiazolyl)imino)-1-imidazolidineethanol
24240-70-8
2-(1-(2-Hydroxyaethyl)-1,3-imidazolidinyliden-(2)-amino)-5-nitrothiazol [German]
2-(1-(2-Hydroxyaethyl)-1,3-imidazolidinyliden-(2)-amino)-5-nitrothiazol
RefChem:230971
DTXCID20101427