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clotrimazole

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Identification
Molecular formula
C22H17Cl2N3
CAS number
23593-75-1
IUPAC name
2-(2-benzylbenzimidazol-1-yl)ethyl-diethyl-ammonium;chloride
State
State

Clotrimazole is typically found in a solid state at room temperature.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
450.00
Boiling point (Kelvin)
723.15
General information
Molecular weight
344.85g/mol
Molar mass
344.8450g/mol
Density
1.1290g/cm3
Appearence

Clotrimazole is a white to pale yellow crystalline powder. It is odorless.

Comment on solubility

Solubility of 2-(2-benzylbenzimidazol-1-yl)ethyl-diethyl-ammonium;chloride

The solubility of 2-(2-benzylbenzimidazol-1-yl)ethyl-diethyl-ammonium;chloride in different solvents can yield intriguing insights into its chemical behavior. Being a quaternary ammonium compound, it often exhibits distinct solubility characteristics:

  • Aqueous Solutions: Generally, quaternary ammonium salts, particularly those with bulky hydrophobic groups like benzyl groups, are highly soluble in water due to their ionic nature.
  • Organic Solvents: This compound may demonstrate varying solubility in organic solvents, typically showing moderate solubility in polar solvents like ethanol and methanol, but may become less soluble in non-polar solvents.
  • pH Influence: The solubility can also be affected by the pH of the solution. It tends to be more soluble in acidic media compared to neutral or basic conditions, owing to the protonation state of the nitrogen atoms.
  • Temperature Effects: Increasing the temperature can enhance the solubility of many salts, including this compound, a phenomenon driven by the increased kinetic energy of molecules.

As with many compounds, the presence of substituents like the benzimidazole moiety also influences solubility parameters. Thus, understanding the solubility of 2-(2-benzylbenzimidazol-1-yl)ethyl-diethyl-ammonium;chloride involves a careful consideration of the solvent system and environmental conditions. An insightful quote to remember:

"Solubility is a window into the molecular world, revealing the interactions between the solute, solvent, and condition."

Interesting facts

Interesting Facts About 2-(2-benzylbenzimidazol-1-yl)ethyl-diethyl-ammonium chloride

This intriguing compound, known as 2-(2-benzylbenzimidazol-1-yl)ethyl-diethyl-ammonium chloride, is a remarkable example of an organic ammonium compound that showcases the fascinating interplay between organic and inorganic chemistry. Below are some noteworthy aspects:

  • Structural Complexity: The compound features a unique structure that combines a benzimidazole moiety—a benzene ring fused to an imidazole ring—providing notable biological activity.
  • Biological Significance: Compounds containing benzimidazole derivatives are often noted for their pharmacological properties. They can exhibit effects such as anti-parasitic and anti-tumor activities, making them a subject of interest in medicinal chemistry.
  • Quaternary Ammonium Properties: As a quaternary ammonium salt, it possesses characteristics such as being a potential surfactant. This means it can reduce surface tension in solutions and may have applications in formulations.
  • Applications in Research: The presence of both an amine and a diethyl chain allows for the exploration of interaction mechanisms within cellular systems, thereby enhancing its utility in laboratories focused on structural biology and drug design.

In conclusion, 2-(2-benzylbenzimidazol-1-yl)ethyl-diethyl-ammonium chloride serves as a rich subject for study due to its structural complexity and potential applications in various scientific fields. As noted by researchers, "The fusion of organic chemistry with biological applications opens new avenues for innovative discoveries."


As we further explore its properties and functionalities, we can unveil more about its role in both foundational and applied chemistry.

Synonyms
2-Benzyl-1-(diethylaminoethyl)benzimidazole hydrochloride
17817-84-4
BENZIMIDAZOLE, 2-BENZYL-1-(DIETHYLAMINOETHYL)-, HYDROCHLORIDE