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Diphenhydramine

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Identification
Molecular formula
C17H21NO
CAS number
58-73-1
IUPAC name
2-(2-benzylphenoxy)-N,N-dimethyl-ethanamine
State
State

Diphenhydramine is generally in a solid state at room temperature. It is commonly encountered as its hydrochloride salt to increase stability and solubility in medicinal preparations.

Melting point (Celsius)
167.00
Melting point (Kelvin)
440.15
Boiling point (Celsius)
384.70
Boiling point (Kelvin)
657.85
General information
Molecular weight
255.34g/mol
Molar mass
255.3430g/mol
Density
1.0198g/cm3
Appearence

Diphenhydramine is typically found as a white, crystalline powder. It is odorless and has a bitter taste. It is soluble in water, and more soluble in alcohol and chloroform.

Comment on solubility

Solubility of 2-(2-benzylphenoxy)-N,N-dimethyl-ethanamine

The solubility of 2-(2-benzylphenoxy)-N,N-dimethyl-ethanamine plays a critical role in its application and effectiveness in various contexts. Understanding its solubility can guide its use in formulations, reactions, or as a potential therapeutic agent. Here are some key aspects regarding its solubility:

  • Polarity: This compound has a relatively complex structure, which can influence its overall polarity. Generally, compounds with aromatic groups tend to show varied solubility in polar and non-polar solvents.
  • Solvent Compatibility: The solubility of 2-(2-benzylphenoxy)-N,N-dimethyl-ethanamine may be greater in organic solvents like ethanol, dichloromethane, or methanol compared to water, due to its larger hydrophobic components.
  • Temperature Influence: Like many organic compounds, the solubility can be *temperature-dependent*, often increasing with higher temperatures, due to enhanced kinetic energy that helps overcome intermolecular forces.
  • pH Sensitivity: If the solution’s pH varies significantly, the ionization state of this amine may change, affecting solubility. An *alkaline environment* can increase the solubility of amines by enabling protonation, while an *acidic environment* might hinder it.

In conclusion, **understanding the solubility parameters** of 2-(2-benzylphenoxy)-N,N-dimethyl-ethanamine is crucial for its effective application in both theoretical and practical settings. Its solubility will not only dictate its usability in scientific investigations but also in potential industrial applications.

Interesting facts

Interesting Facts about 2-(2-benzylphenoxy)-N,N-dimethyl-ethanamine

2-(2-benzylphenoxy)-N,N-dimethyl-ethanamine is a fascinating compound that has garnered interest in various fields of research due to its unique structure and potential applications. Here are some intriguing aspects of this compound:

  • Complex Structure: The core structure features a benzyl group and a phenoxy moiety, which contribute to its chemical reactivity and can influence **biological activities**.
  • Biomedical Potential: Compounds with similar structural features are often studied for their potential pharmacological properties. This compound might exhibit activities such as antidepressant or antipsychotic properties, making it a candidate for further research.
  • Applications in Synthesis: The presence of both amine and ether functionalities allows for potential utility in organic synthesis. This compound could serve as an intermediate in the synthesis of more complex molecules.
  • Environmental Considerations: As with many organic compounds, understanding the environmental impact and degradation pathways of 2-(2-benzylphenoxy)-N,N-dimethyl-ethanamine is essential for safe and responsible application, especially if it is deployed in pharmaceuticals.
  • Mechanistic Studies: The compound's unique properties are fascinating to study, as they may allow scientists to explore the mechanism of action for various pathways and interactions in biological systems.
  • Future Research: Ongoing research may uncover new uses of this compound, especially in the fields of medicinal chemistry and agrochemicals, potentially leading to innovative therapies or environmentally friendly pesticides.

Overall, 2-(2-benzylphenoxy)-N,N-dimethyl-ethanamine represents a bridge between synthetic chemistry and applied sciences. Scientists continue to be intrigued by compounds like this, pushing the boundaries of our understanding of chemical interactions and practical applications.

Synonyms
Phenyltoloxamine
92-12-6
Phentoloxamine
Phenoxadrin
Phenoxadrine
Bistrimin
Bristamin
Histionex
Antin
Feniltoloxamina
Feniltolossamina
Phenyltoloxaminum
Feniltolossamina [DCIT]
Phenyltoloxamine [INN:BAN]
2-(2-Benzylphenoxy)-N,N-dimethylethanamine
Feniltoloxamina [INN-Spanish]
Phenyltoloxaminum [INN-Latin]
Fenoxadrin
Phentoloxamin
EINECS 202-127-9
UNII-K65LB6598J
C 5581H
BRN 1986598
2-(2-Dimethylaminoethoxy)diphenylmethane
N,N-Dimethyl-2-(alpha-phenyl-o-tolyloxy)ethylamine
Floxamine (Salt/Mix)
K65LB6598J
N,N-Dimethyl-2-(2-(phenylmethyl)phenoxy)ethanamine
PHENYLTOLOXAMINE [MI]
PHENYLTOLOXAMINE [INN]
Ethanamine, N,N-dimethyl-2-(2-(phenylmethyl)phenoxy)-
Ethanamine, N,N-dimethyl-2-[2-(phenylmethyl)phenoxy]-
CHEMBL186720
Ethanamine, N,N-dimethyl-2-((alpha-phenyl-o-tolyl)oxy)-
PHENYLTOLOXAMINE [VANDF]
DTXSID9023467
PHENYLTOLOXAMINE [WHO-DD]
4-06-00-04630 (Beilstein Handbook Reference)
[2-(2-benzylphenoxy)ethyl]dimethylamine
C 5581 H
2-[2-(Dimethylamino)ethoxy]diphenylmethane
2-(2-Benzylphenoxy)-N,N-dimethylethylamine
o-Benzylphenyl 2-(dimethylamino)ethyl ether
2-Benzylphenyl-.beta.-dimethylamino ethyl ether
Antin; Bistrimin; Bristamin; C 5581H; Histionex
Feniltoloxamina (INN-Spanish)
N,N-Dimethyl-2-(.alpha.-phenyl-o-toloxy)ethylamine
Phenyltoloxaminum (INN-Latin)
N,N-Dimethyl-2-((.alpha.-phenyl-o-tolyl)oxy)ethylamine
Ethylamine, N,N-dimethyl-2-[(.alpha.-phenyl-o-tolyl)oxy]-
N,N-DIMETHYL-2-(.ALPHA.-PHENYL-O-TOLYLOXY)ETHYLAMINE
(2-(2-benzylphenoxy)ethyl)dimethylamine
2-(2-(Dimethylamino)ethoxy)diphenylmethane
SCHEMBL28854
DTXCID703467
CHEBI:135047
HY-B1733
BDBM50151046
DB11160
Dimethyl{2-[2-benzylphenoxy]ethyl}amine
NCGC00021141-01
NCGC00021141-02
NCGC00021141-03
NCGC00022229-03
DA-76816
2-(2-benzylphenoxy)-N,N-dimethyl-ethanamine
2-Benzylphenyl-beta-dimethylamino ethyl ether
CS-0013741
NS00002981
[2-(2-Benzyl-phenoxy)-ethyl]-dimethyl-amine
2-(2-Benzylphenoxy)-N,N-dimethylethanamine #
2-(2-Benzylphenoxy)-N,N-dimethylethan-1-amine
EN300-18529585
N,N-Dimethyl-2-(alpha-phenyl-o-toloxy)ethylamine
Q7181443
N,N-Dimethyl-2-((alpha-phenyl-o-tolyl)oxy)ethylamine
N,N-dimethyl-2-{[2-(phenylmethyl)phenyl]oxy}ethanamine
ETHYLAMINE, N,N-DIMETHYL-2-((alpha-PHENYL-o-TOLYL)OXY)-
202-127-9