Minoxidil | Solubility of Things

Identification

Molecular formula

C₉H₁₅N₅O

CAS number

38304-91-5

IUPAC name

2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(1-piperidyl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

State

At room temperature, Minoxidil is in a solid state, typically appearing as a crystalline powder.

Melting point (Celsius)

248.00

Melting point (Kelvin)

521.15

Boiling point (Celsius)

527.00

Boiling point (Kelvin)

800.15

General information

Molecular weight

209.25g/mol

Molar mass

209.2500g/mol

Density

1.3100g/cm³

Appearence

Minoxidil is a white to off-white crystalline powder. It may appear slightly yellowish due to exposure to certain environmental conditions. It is typically supplied in a solid crystalline form, which is odorless and soluble in propylene glycol and ethanol, but poorly soluble in water.

Comment on solubility

Solubility of 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(1-piperidyl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

Understanding the solubility of complex compounds like 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(1-piperidyl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol (C₉H₁₅N₅O) is crucial for its application in various fields. Here are some key points regarding its solubility:

Polarity: Given the presence of multiple hydroxyl groups and amino functions in the structure, it is expected that the compound has a significant degree of polarity. This typically enhances solubility in polar solvents like water.
Hydrogen Bonding: The ability to form hydrogen bonds due to the -OH and -NH groups suggests that this compound would interact favorably with water molecules, further increasing its solubility.
Influence of pH: The solubility can also be influenced by the pH of the solution due to possible protonation reactions, particularly in basic or acidic environments.
Temperature Effects: Solubility may vary with temperature; as temperatures rise, solubility in water typically increases, which should be taken into account during any experimental procedures.

In summary, this compound is likely to exhibit good solubility in polar solvents, particularly water, due to its structural characteristics that promote hydrogen bonding and high polarity.

Interesting facts

Interesting Facts about 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(1-piperidyl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

This compound belongs to a fascinating class of molecules known as pyrimidines, which are pivotal in various biological systems and applications. Pyrimidines serve as essential building blocks in the synthesis of nucleic acids, while also showing promise in medicinal chemistry as potential pharmaceuticals.

Key Attributes:

Complex Structure: The multi-functional structure, featuring various amine and hydroxyl groups, allows this compound to interact with biological systems in unique ways.
Medicinal Potential: Compounds bearing similar structural characteristics have been investigated for their role in treating a range of diseases, including cancer and infectious diseases.
Interaction Capabilities: The presence of multiple amine functionalities may enhance its ability to form hydrogen bonds, thereby improving its interaction with biological macromolecules.

Applications in Research:

Research into this compound could yield insights into:

Drug Development: Given its structural features, it could be a candidate for novel therapeutic agents.
Biochemical Research: It may serve as a useful probe in biochemical pathways due to its complex behavior in biological settings.

In summary, the compound showcases a blend of intriguing chemical attributes and potential applications, making it a compelling subject for chemists and pharmacologists alike. Its synthesis and elucidation could provide deeper understanding in various research realms.

Synonyms

dipyridamole

58-32-2

Persantin

Dipyridamine

Dipyridamol

Persantine

Dipyudamine

Curantyl

Dipiridamol

Stenocardil

Stimolcardio

Kurantil

Cardioflux

Cardoxin

Dipyridan

Peridamol

Anginal

Apricor

Coribon

Corosan

Coroxin

Chilcolan

Justpertin

Permiltin

Stenocardiol

Agilease

Piroan

Cleridium 150

Coronarine

Gulliostin

Prandiol

Natyl

Prandiol 75

Usaf Ge-12

Dypyridamol

Iv Persantine

Dipyridamolum

2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl))tetraethanol

RA-8

RA 8

NSC-515776

Dipiridamol [INN-Spanish]

Dipyridamolum [INN-Latin]

NSC 515776

EINECS 200-374-7

UNII-64ALC7F90C

BRN 0068373

64ALC7F90C

CHEBI:4653

MLS000028420

2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol

DTXSID6040668

B01AC07

Cleridium

Dipyridamole (Persantine)

Dypyridamole

MFCD00010555

NSC515776

CHEMBL932

2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)pyrimidine

SMR000058382

Pyrimido(5,4-d)pyrimidine, 2,6-bis(bis(2-hydroxyethyl)amino)-4,8-dipiperidino-

2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

Dipyramidole

Cardoxil

DTXCID4020668

4-26-00-03840 (Beilstein Handbook Reference)

2,2',2'',2'''-((4,8-Dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetraethanol

AGGRENOX COMPONENT DIPYRIDAMOLE

2,2',2'',2'''-((4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl))tetrakis(ethan-1-ol)

Ethanol, 2,2',2'',2'''-((4,8-di-1-piperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-

Ethanol, 2,2',2'',2'''-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-

Ethanol,2,2',2'',2'''-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-

CAS-58-32-2

Dipyridamole [USAN:USP:INN:BAN:JAN]

NCGC00015385-12

Coridil

Protangix

2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine

Dipiridamol (INN-Spanish)

Dipyridamolum (INN-Latin)

Ethanol, 2,2',2'',2'''-((4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetra-

DIPYRIDAMOLE (MART.)

DIPYRIDAMOLE [MART.]

2,2',2'',2'''-{[4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo}tetraethanol

DIPYRIDAMOLE (USP-RS)

DIPYRIDAMOLE [USP-RS]

C24H40N8O4

Permole

DIPYRIDAMOLE (EP MONOGRAPH)

DIPYRIDAMOLE [EP MONOGRAPH]

DIPYRIDAMOLE (USP MONOGRAPH)

DIPYRIDAMOLE [USP MONOGRAPH]

Persantine (TN)

Dipyridamole (USAN:USP:INN:BAN:JAN)

(3E)-3-[[(1S,4aS,8aS)-Decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]methylene]dihydro-5-methoxy-2(3H)3-[(1E)-2-[(1S,4aS,8aS)-Decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]ethenyl]furan; (+)-Coronarin E-furanone; Coronarin D methyl ethe

SR-01000003065

dipiridamolo

Dipridacot

Dipridamole

Curanty

2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetraethanol

2,2',2'',2'''-((4,8-dipiperidin-1-ylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetraethanol

2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol

Dipyridamole; 2,2',2'',2'''-[[4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetraethanol

H9F

Prestwick_145

Spectrum_001004

Tocris-0691

Dipyridamole (Standard)

Opera_ID_494

Prestwick0_000142

Prestwick1_000142

Prestwick2_000142

Prestwick3_000142

Spectrum2_000972

Spectrum3_000402

Spectrum4_000522

Spectrum5_000839

DIPYRIDAMOLE [MI]

Lopac-D-9766

DIPYRIDAMOLE [INN]

DIPYRIDAMOLE [JAN]

UPCMLD-DP072

D 9766

DIPYRIDAMOLE [USAN]

cid_3108

DIPYRIDAMOLE [VANDF]

Lopac0_000464

SCHEMBL16119

BSPBio_000244

BSPBio_001554

BSPBio_001924

KBioGR_001123

KBioSS_001484

MLS001076306

MLS001333724

MLS002548866

DIPYRIDAMOLE [WHO-DD]

DivK1c_000696

SPECTRUM1500259

SPBio_001003

SPBio_002183

BPBio1_000270

GTPL4807

Thymidine,6-dihydro-6-methoxy-

UPCMLD-DP072:001

BDBM23620

Dipyridamole (JP18/USP/INN)

HMS502C18

HY-B0312R

IZEKFCXSFNUWAM-UHFFFAOYSA-

KBio1_000696

KBio2_001484

KBio2_004052

KBio2_006620

KBio3_001144

NINDS_000696

BCPP000256

DIPYRIDAMOLE [ORANGE BOOK]

HMS1568M06

HMS1791N16

HMS1920I10

HMS1989N16

HMS2089N15

HMS2091O18

HMS2095M06

HMS2232E19

HMS3259C03

HMS3261M10

HMS3266J17

HMS3371J03

HMS3402N16

HMS3411B03

HMS3655I20

HMS3675B03

HMS3712M06

HMS3742O03

HMS3867F13

Pharmakon1600-01500259

BCP26947

HY-B0312

PXB98352

Tox21_110133

Tox21_500464

2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine

BBL027781

CCG-40190

NSC756743

s1895

STL377790

AKOS000509426

Tox21_110133_1

BCP9000613

DB00975

Dipyridamole, >=98% (TLC), powder

FD22534

HS-0041

LP00464

NC00448

NSC-619103

NSC-756743

SDCCGSBI-0050449.P005

IDI1_000696

SMP2_000208

DIPYRIDAMOLE COMPONENT OF AGGRENOX

NCGC00015385-01

NCGC00015385-02

NCGC00015385-03

NCGC00015385-04

NCGC00015385-05

NCGC00015385-06

NCGC00015385-07

NCGC00015385-08

NCGC00015385-09

NCGC00015385-10

NCGC00015385-11

NCGC00015385-13

NCGC00015385-14

NCGC00015385-15

NCGC00015385-16

NCGC00015385-17

NCGC00015385-18

NCGC00015385-29

NCGC00023914-02

NCGC00023914-04

NCGC00023914-05

NCGC00023914-06

NCGC00023914-07

NCGC00023914-08

NCGC00023914-09

NCGC00023914-10

NCGC00023914-11

NCGC00261149-01

2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyrimido[5,4-d]-pyrimidine-2,6-diyl)bis(azanetriyl))tetraethanol

2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)-[1,3]diazino[5,4-d]pyrimidin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol

2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(1-piperidyl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

AC-18100

AC-30804

NCI60_005689

SBI-0050449.P004

2,8-dipiperidinopyrimido[5,4-d]pyrimidine

AB00051974

EU-0100464

NS00010369

SW196456-3

EN300-70723

BIM-0050449.0001

D00302

O10551

AB00051974-18

AB00051974-19

AB00051974_20

AB00051974_21

Q419374

SR-01000003065-2

SR-01000003065-4

SR-01000003065-5

SR-01000003065-7

BRD-K86301799-001-04-1

BRD-K86301799-001-19-9

BRD-K86301799-001-24-9

BRD-K86301799-001-34-8

BRD-K86301799-001-35-5

BRD-K86301799-001-36-3

BRD-K86301799-001-37-1

Z1137167676

Dipyridamole, British Pharmacopoeia (BP) Reference Standard

Dipyridamole, European Pharmacopoeia (EP) Reference Standard

Dipyridamole, United States Pharmacopeia (USP) Reference Standard

Pyrimido(5, 2,6-bis[bis(2-hydroxyethyl)amino]-4,8-diperidino-

2,2'',2'''-[4,8-Dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilotetraethanol

2,2',2'',2'''-(4,8-Dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilotetraethanol

2-[[2-(bis(2-hydroxyethyl)amino)-4,8-di(piperidin-1-yl)pyrimido[6,5-e]pyrimidin-

Dipyridamole for peak identification, European Pharmacopoeia (EP) Reference Standard

Ethanol,2',2'',2'''-(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetra-

WLN: T66 BN DN GN INJ CCN HCN E- AT6NTJ B2Q F2Q& J- AT6NTJ B2Q F2Q

2,2',2'',2''''-((4,8-Dipiperidinopyrimido-(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetraethanol

2,2',2'',2'''-(4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl)tetraethanol

2,2',2'',2'''-[(4,8-Di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-ethanol;2,6-Bis(diethanolamino)-4,8-dipipe ridinopyrimido[5,4-d]pyrimidine

2,2',2'',2'''-[(4,8-Dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol

2,2',2'',2'''-[(4,8-Dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol

200-374-7

Ethanol, 2,2',2'',2'''-(4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyldinitrilo)tetra-

Ethanol, 2,2',2',2'''-((4,8-di-1-iperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-

Ethanol,2',2'',2'''-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-

Ethanol,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetra-

InChI=1/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2