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2-(Bromo-benzyl)guanidine

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Identification
Molecular formula
C8H10BrN3
CAS number
400783-88-4
IUPAC name
2-[(2-bromophenyl)methyl]guanidine
State
State

This compound is generally observed as a solid at room temperature, owing to its crystalline structure and relatively high molecular weight.

Melting point (Celsius)
175.00
Melting point (Kelvin)
448.15
Boiling point (Celsius)
325.50
Boiling point (Kelvin)
598.65
General information
Molecular weight
227.09g/mol
Molar mass
227.0660g/mol
Density
2.1980g/cm3
Appearence

2-(Bromo-benzyl)guanidine appears as a crystalline solid which can be colorless or may have a white to off-white appearance. Its crystalline structure is typically fine and it might form as needles or powder.

Comment on solubility

Solubility of 2-[(2-bromophenyl)methyl]guanidine

When considering the solubility of 2-[(2-bromophenyl)methyl]guanidine, several factors come into play that affect its behavior in various solvents. This compound, featuring a guanidine structure with a bromobenzyl substituent, can exhibit interesting solubility characteristics due to its functional groups.

Key Factors Affecting Solubility:

  • Polarity: Guanidines are generally polar due to the presence of NH bonds, which can facilitate hydrogen bonding with solvents like water.
  • Hydrophobic Character: The 2-bromophenyl group introduces a degree of hydrophobicity, potentially decreasing overall solubility in aqueous solutions.
  • Temperature: Temperature variations can significantly impact solubility, often increasing the solubility of organic compounds at higher temperatures.
  • Solvent Choice: The solubility can be markedly different in various organic solvents. For example, ethanol and DMSO may solvate the compound better due to polarity and hydrogen bonding capabilities.

In conclusion, while 2-[(2-bromophenyl)methyl]guanidine is likely to be more soluble in polar organic solvents than in water, the exact solubility profile will depend on the interplay of these factors. As with many organic compounds, understanding the specific solvation dynamics is essential for predicting solubility behavior in practical applications.

Interesting facts

Interesting Facts about 2-[(2-bromophenyl)methyl]guanidine

2-[(2-bromophenyl)methyl]guanidine is a fascinating compound with diverse applications in the field of chemistry and pharmaceutical sciences. Here are some of the intriguing aspects of this compound:

  • Pharmacological Potential: The structure of 2-[(2-bromophenyl)methyl]guanidine suggests it may exhibit significant biological activity, potentially as an antidiabetic agent or in modulating neurotransmitter systems.
  • Structural Features: This compound contains a guanidine functional group, characterized by versatile reactivity. Its structure allows for various interactions with biological receptors.
  • Substituent Effects: The presence of the bromophenyl group can greatly influence the compound's reactivity and biological properties, illustrating the vital role that substituents play in organic chemistry.
  • Synthesis Interest: The synthesis of 2-[(2-bromophenyl)methyl]guanidine usually involves advanced organic reactions, including nucleophilic substitutions, offering students unique learning opportunities in synthetic methodologies.
  • Research Applications: Compounds like 2-[(2-bromophenyl)methyl]guanidine are often used in research to study mechanisms of drug action and the development of new therapeutic agents, emphasizing the importance of structure-activity relationships.

In conclusion, 2-[(2-bromophenyl)methyl]guanidine serves as a prime example of how structure and functional groups can influence both reactivity and application in the scientific community. As research advances in medicinal chemistry, studying such compounds becomes increasingly relevant.

Synonyms
3911-38-4
GUANIDINE, (o-BROMOBENZYL)-
(o-Bromobenzyl)guanidine
BRN 2937232
Guanidine, ((2-bromophenyl)methyl)-
DTXSID40192357
DTXCID50114848
1-(2-Bromobenzyl)guanidine
(2-Bromobenzyl)guanidine
N-[(2-BROMOPHENYL)METHYL]GUANIDINE
CHEMBL451945
SCHEMBL4018473
MFCD00460581
STL299686
AKOS011645352
SY340562
EN300-1692584