Skip to main content

Niflumic acid

ADVERTISEMENT
Identification
Molecular formula
C13H8ClNO3
CAS number
4394-00-7
IUPAC name
2-(2-carboxyanilino)-4-chloro-benzoic acid
State
State

At room temperature, niflumic acid is in a solid state. It is primarily used in medicinal applications and is often formulated into tablets or capsules.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
533.30
Boiling point (Kelvin)
806.45
General information
Molecular weight
282.66g/mol
Molar mass
282.6580g/mol
Density
1.5416g/cm3
Appearence

Niflumic acid typically appears as a crystalline solid that is white to slightly yellowish in color. It is often found in powder form for pharmaceutical applications.

Comment on solubility

Solubility of 2-(2-carboxyanilino)-4-chloro-benzoic acid

The solubility of 2-(2-carboxyanilino)-4-chloro-benzoic acid (C13H8ClNO3) can be influenced by various factors, primarily its molecular structure.

Key points regarding its solubility include:

  • Polarity: The presence of carboxylic acid groups enhances polarity, which can increase solubility in water.
  • Hydrogen Bonding: This compound may form hydrogen bonds with water molecules, facilitating its dissolution in polar solvents.
  • Solvent Type: It is expected to be more soluble in *polar solvents* such as methanol or ethanol compared to *non-polar solvents* like hexane.
  • pH Dependency: The solubility can vary with pH; at higher pH levels, the carboxylic acid group may deprotonate, increasing solubility.

In conclusion, while 2-(2-carboxyanilino)-4-chloro-benzoic acid displays characteristics that suggest good solubility in polar environments, the exact solubility can vary based on environmental conditions such as pH and solvent type. This compound's ability to engage in intermolecular interactions is crucial for its dissolution behavior, making it a fascinating topic for further study.

Interesting facts

Interesting Facts About 2-(2-carboxyanilino)-4-chloro-benzoic Acid

2-(2-carboxyanilino)-4-chloro-benzoic acid, commonly referred to as a type of benzoic acid derivative, showcases some intriguing characteristics that make it a compound of interest in both organic chemistry and medicinal chemistry. Here are some captivating aspects of this compound:

  • Chemical Structure: The compound features a benzoic acid framework with a chlorine atom and a carboxyanilino group, demonstrating a range of potential reactivity.
  • Biological Activity: Compounds like this one often exhibit biological properties, which could include anti-inflammatory or antimicrobial activities, making them valuable in drug development.
  • Synthesis Pathways: Its synthesis may involve multi-step reactions, which provide an excellent opportunity for students to explore concepts like nucleophilic substitution and carboxylation.
  • Applications: 2-(2-carboxyanilino)-4-chloro-benzoic acid finds its uses not only in pharmaceuticals but also in areas such as dyes and agrochemicals, highlighting its versatility.
  • Research Potential: Ongoing studies on chemically modified benzoic acids create significant opportunities for enhancing efficacy and selectivity in therapeutic applications.

In summary, 2-(2-carboxyanilino)-4-chloro-benzoic acid stands out due to its complex structure and potential applications. As researchers delve deeper into its properties, the compound could pave the way for innovative solutions in various chemical and biological fields. As the renowned chemist Linus Pauling once said, “The best way to have a good idea is to have a lot of ideas,” and compounds like this one certainly contribute to that pool of profound possibilities.

Synonyms
Lobenzarit
63329-53-3
Lobenzarit [INN]
Lobenzaritum
2-((2-carboxyphenyl)amino)-4-chlorobenzoic acid
Lobenzaritum [INN-Latin]
2-[(2-carboxyphenyl)amino]-4-chlorobenzoic acid
4-Chlor-2,2'-iminodibenzoesaiure
2-(2-carboxyanilino)-4-chlorobenzoic acid
UNII-915EE91P39
LOBENZARIT [MI]
915EE91P39
LOBENZARIT [WHO-DD]
Benzoic acid, 2-((2-carboxyphenyl)amino)-4-chloro-
4-chloro-2,2'-iminodibenzoate
DTXSID20212709
lobenzart
CCA lobenzarit
Lobenzaritum (INN-Latin)
4-chloro-2,2'-iminodibenzoic acid
BENZOIC ACID, 2-[(2-CARBOXYPHENYL)AMINO]-4-CHLORO-, DISODIUM SALT
N-(2-carboxyphenyl)-4-chloroanthranilic acid
disodium 2-[(2-carboxylatophenyl)amino]-4-chlorobenzoate
SCHEMBL187951
CHEMBL1986706
DTXCID00135200
CHEBI:135215
BDBM50591384
AKOS037647002
111GE011
AS-71902
DB-054458
HY-124411
2-(2-carboxyphenylamino)-4-chlorobenzoic acid
F75214
A834330
Q6663655
2-[(2-carboxyphenyl)amino]-4-chloranyl-benzoic acid
BRD-K55847762-304-01-7