Skip to main content

Sulfasalazine

ADVERTISEMENT
Identification
Molecular formula
C18H14N4O5S
CAS number
599-79-1
IUPAC name
2-[(2-carboxyphenyl)sulfamoyl]-5-[(3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-yl)azo]benzoic acid
State
State

Sulfasalazine is typically a solid at room temperature. It is commonly found in tablet form for pharmaceutical use.

Melting point (Celsius)
240.00
Melting point (Kelvin)
513.15
Boiling point (Celsius)
422.00
Boiling point (Kelvin)
695.15
General information
Molecular weight
398.39g/mol
Molar mass
398.3940g/mol
Density
1.6090g/cm3
Appearence

Sulfasalazine appears as a yellow-orange crystalline powder. It is practically tasteless and odorless.

Comment on solubility

Solubility of 2-[(2-carboxyphenyl)sulfamoyl]-5-[(3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-yl)azo]benzoic acid

The solubility of the compound C18H14N4O5S, known for its complex structure, is influenced by several factors:

  • Polarity: Due to the presence of both carboxylic acid and sulfonamide functional groups, this compound exhibits notable polar characteristics, which can enhance solubility in polar solvents.
  • Hydrogen Bonding: The carboxylic group can participate in hydrogen bonding, potentially increasing solubility in polar solvents like water.
  • Solvent Selection: This compound may show variable solubility in different organic solvents, such as dimethyl sulfoxide (DMSO) or methanol, where its interaction with solvent molecules will dictate its solubility limits.
  • Experimental Data: Empirical testing is needed to quantify exact solubility values, which could vary widely depending on conditions.

As a general guideline, compounds with similar structures often present the following solubility traits:

  1. Higher solubility in polar solvents.
  2. Moderate to low solubility in non-polar solvents.
  3. Solubility may be affected by temperature and pH levels.

In conclusion, understanding the solubility profile of this compound is essential for its application in pharmaceutical formulations, where the appropriate solvent can significantly enhance compound bioavailability.

Interesting facts

Interesting Facts About 2-[(2-Carboxyphenyl)sulfamoyl]-5-[(3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-yl)azo]benzoic Acid

This compound is a fascinating example of how complex organic structures can play important roles in medicinal chemistry. Here are some interesting facts about this unique molecule:

  • Pharmacological Potential: Compounds of this nature often exhibit significant biological activities, which makes them potential candidates for drug development. The sulfamoyl group is particularly known for its antibacterial properties.
  • Diverse Functional Groups: The presence of various functional groups—including a carboxylic acid, sulfonamide, and azo group—enables this molecule to engage in multiple reactions, thereby enhancing its potential applications in organic synthesis and medicinal chemistry.
  • Azo Compounds: The azo linkage in this compound is noteworthy. Azo compounds are known for their vibrant colors and are widely used as dyes. Additionally, they can undergo reactions that make them useful in a variety of biochemical applications.
  • Pyrazole Derivatives: The inclusion of a pyrazole ring, which is present in various pharmaceuticals, contributes to the compound's bioactivity. Pyrazole derivatives are often investigated for anti-inflammatory and analgesic properties.
  • Research Interest: Due to its multifaceted structure, this compound is of great interest in the field of cancer research, where compounds with specific bioactive functions are in demand to target cancer cells selectively.

As students and scientists dive deeper into the study of such complex molecules, they often quote the words of chemist Linus Pauling, who said, “The best way to have a good idea is to have a lot of ideas.” This encourages exploration in the realm of organic chemistry, where compounds like the one discussed can lead to innovative discoveries.

In summary, 2-[(2-carboxyphenyl)sulfamoyl]-5-[(3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-yl)azo]benzoic acid illustrates not only the complexity but also the potential these molecular structures hold for transformative applications in health and industry.

Synonyms
DTXSID90864279
2-[(2-Carboxyphenyl)sulfamoyl]-5-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl]benzoic acid