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Amoxapine

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Identification
Molecular formula
C17H16ClNO
CAS number
14028-44-5
IUPAC name
2-[(2-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)oxy]-N,N-dimethyl-ethanamine
State
State

At room temperature, Amoxapine is typically in a solid state. It is stable under normal conditions and should be stored in a tightly sealed container to prevent degradation.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.15
Boiling point (Celsius)
545.60
Boiling point (Kelvin)
818.80
General information
Molecular weight
313.84g/mol
Molar mass
313.8400g/mol
Density
1.1330g/cm3
Appearence

Amoxapine is typically found as an off-white to light yellow powder. It may appear crystalline under particular conditions.

Comment on solubility

Solubility Characteristics

The compound 2-[(2-chloro-5,6-dihydrobenzob[1]benzothiepin-5-yl)oxy]-N,N-dimethyl-ethanamine exhibits notable solubility properties, which are influenced by its molecular structure and functional groups. Understanding the solubility aspects of this compound is essential for its practical applications.

Key Factors Affecting Solubility

  • Polarity: The presence of polar functional groups can enhance the compound's ability to dissolve in polar solvents like water.
  • Hydrophobic Regions: The dihydrobenzo[b][1]benzothiepin moiety introduces hydrophobic characteristics, which can affect solubility in aqueous environments.
  • Ionization: Depending on the pH, the amine group may become protonated, thereby altering solubility in different solvents.

Considering these factors, one could expect varying degrees of solubility in different media:

  1. Water: Moderate solubility may be observed, particularly if the compound's polar functionalities dominate.
  2. Organic Solvents: Likely higher solubility in non-polar or mildly polar organic solvents due to the hydrophobic nature of the major structural components.
  3. Biological Relevance: Solubility significantly influences bioavailability, making it crucial in pharmaceutical contexts.

In summary, the solubility of 2-[(2-chloro-5,6-dihydrobenzob[1]benzothiepin-5-yl)oxy]-N,N-dimethyl-ethanamine is a complex interplay of its chemical structure and the solvent environment. Thus, it's essential to assess solubility experimentally under various conditions to determine its behavior in practical applications.

Interesting facts

Interesting Facts about 2-[(2-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)oxy]-N,N-dimethyl-ethanamine

This compound, with its complex structure, opens an intriguing discussion in the realms of pharmaceuticals and organic chemistry. Here are some noteworthy aspects:

  • Pharmaceutical Potential: The compound shows potential use in various therapeutic applications, particularly in treatments involving neurological disorders.
  • Structural Diversity: Its unique structural elements, including the benzothiepin moiety, contribute to its biological activity and highlight the importance of molecular diversity in drug design.
  • Mechanism of Action: Compounds with similar structures often interact with neurotransmitter systems, such as serotonin or dopamine pathways, making this compound a subject of research in neuropharmacology.
  • Chirality and Isomerism: Understanding the stereochemistry of this compound can reveal significant differences in its efficacy and safety profiles, underlining the importance of chirality in drug chemistry.
  • Synthetic Challenges: The synthesis of such complex compounds can be quite challenging, which presents opportunities for chemists to innovate new synthetic routes and methodologies.

In conclusion, the exploration of 2-[(2-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)oxy]-N,N-dimethyl-ethanamine not only reflects the rich tapestry of organic chemistry but also poses pivotal questions surrounding its applicability in medicine. As research continues, we may uncover further layers of its potential.

Synonyms
AKOS005065509