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Clomipramine

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Identification
Molecular formula
C19H23ClN2OS
CAS number
303-49-1
IUPAC name
2-[(2-chloro-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)oxy]-N,N-dimethyl-ethanamine
State
State

At room temperature, Clomipramine is typically in a solid state. It is stable under the conditions normally encountered in the storage and handling of pharmaceuticals.

Melting point (Celsius)
179.50
Melting point (Kelvin)
452.70
Boiling point (Celsius)
605.30
Boiling point (Kelvin)
878.50
General information
Molecular weight
331.85g/mol
Molar mass
331.8440g/mol
Density
1.4000g/cm3
Appearence

The compound often appears as a white to off-white crystalline powder. It might have little to no odor and is generally solid in its pure form.

Comment on solubility

Solubility of 2-[(2-chloro-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)oxy]-N,N-dimethyl-ethanamine

The solubility characteristics of 2-[(2-chloro-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)oxy]-N,N-dimethyl-ethanamine can be quite intriguing. In general, the solubility of a compound in a given solvent can be influenced by various factors including polarity, hydrogen bonding, and molecular structure. Here are some key points to consider:

  • Polarity: The presence of electron-withdrawing groups, such as chlorine atoms, significantly affects the polarity of the compound, potentially impacting its solubility in polar solvents like water.
  • Hydrophobic regions: The aromatic systems and larger hydrocarbon-like segments may increase the hydrophobic character, thereby reducing solubility in aqueous solutions.
  • Solvent interactions: The choice of solvent plays a critical role; polar solvents (e.g., ethanol) may dissolve the compound better than non-polar ones (e.g., hexane).
  • Temperature dependence: As with many compounds, solubility can change with temperature, generally increasing with elevated temperatures due to increased kinetic energy of molecules.

In summary, while 2-[(2-chloro-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)oxy]-N,N-dimethyl-ethanamine may exhibit limited solubility in water due to its hydrophobic attributes and larger non-polar portions, it is likely to find better solubility in organic solvents. Understanding these parameters is essential for effective application and utilization of the compound in various chemical contexts.

Interesting facts

Interesting Facts about 2-[(2-chloro-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)oxy]-N,N-dimethyl-ethanamine

This compound is a fascinating subject of study in the field of medicinal chemistry, primarily due to its unique structural features and potential pharmacological applications. Here are some engaging insights:

  • Structural Complexity: The compound exhibits a complex structure that combines elements of both benzothiepin and amine functional groups. This complexity can influence its interactions within biological systems.
  • Potential Therapeutic Uses: Compounds similar to this one have been investigated for their potential roles as psychotropic agents. They may interact with neurotransmitter systems, making them of interest in the development of treatments for psychiatric disorders.
  • Chlorination Effects: The presence of a chlorine atom in the structure can significantly modify the compound’s biological activity and lipophilicity, impacting how it behaves in a physiological environment.
  • Derivative Exploration: Researchers are keen to explore derivatives of this compound to enhance efficacy or reduce side effects, showcasing the importance of structure-activity relationships in drug discovery.
  • Research Applications: Beyond its potential therapeutic uses, this compound serves as an important lead compound for synthetic chemists looking to develop new materials or study reaction mechanisms.

As you delve into the study of this compound, consider that its unique attributes not only underscore the intricacies of chemical design but also illustrate the ongoing quest to uncover new therapeutic agents in modern medicine. Science continues to unveil the mysteries behind such compounds, amplifying their significance in both practical and theoretical chemistry.

Synonyms
AKOS005065539